UniProtKB - E9PJK1 (E9PJK1_HUMAN)
Protein
Tetraspanin
Gene
CD81
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Names & Taxonomyi
Protein namesi | Recommended name: TetraspaninUniRule annotation |
Gene namesi | Name:CD81Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1701, CD81 |
VEuPathDBi | HostDB:ENSG00000110651.11 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 43 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 131 – 155 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | E9PJK1 |
PRIDEi | E9PJK1 |
ProteomicsDBi | 21166 |
PTM databases
SwissPalmi | E9PJK1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110651, Expressed in stromal cell of endometrium and 243 other tissues |
ExpressionAtlasi | E9PJK1, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000158805 |
HOGENOMi | CLU_055524_10_1_1 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
E9PJK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMFVGFLGCY GAIQESQCLL GTFFTCLVIL FACEVAAGIW GFVNKDQIAK
60 70 80 90 100
DVKQFYDQAL QQAVVDDDAN NAKAVVKTFH ETLDCCGSST LTALTTSVLK
110 120 130 140 150
NNLCPSGSNI ISNLFKEDCH QKIDDLFSGK LYLIGIAAIV VAVIMIFEMI
160
LSMVLCCGIR NSSVY
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP60033 | CD81_HUMAN | CD81 antigen | CD81 TAPA1, TSPAN28 | 236 | Annotation score: | ||
A6NMH8 | A6NMH8_HUMAN | Tetraspanin | CD81 | 274 | Annotation score: | ||
E9PRJ8 | E9PRJ8_HUMAN | Tetraspanin | CD81 | 209 | Annotation score: | ||
E9PIF1 | E9PIF1_HUMAN | Tetraspanin | CD81 | 242 | Annotation score: | ||
H0YEE2 | H0YEE2_HUMAN | Tetraspanin | CD81 | 148 | Annotation score: | ||
H0YDJ9 | H0YDJ9_HUMAN | Tetraspanin | CD81 | 225 | Annotation score: | ||
H0YDL9 | H0YDL9_HUMAN | Tetraspanin | CD81 | 221 | Annotation score: | ||
E9PQV4 | E9PQV4_HUMAN | CD81 antigen | CD81 | 99 | Annotation score: | ||
E9PM31 | E9PM31_HUMAN | CD81 antigen | CD81 | 92 | Annotation score: | ||
E9PPF5 | E9PPF5_HUMAN | CD81 antigen | CD81 | 51 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124057 Genomic DNA No translation available. AC129929 Genomic DNA No translation available. |
RefSeqi | NP_001284578.1, NM_001297649.1 XP_016874087.1, XM_017018598.1 |
Genome annotation databases
Ensembli | ENST00000492627; ENSP00000437242; ENSG00000110651 ENST00000526072; ENSP00000431780; ENSG00000110651 |
GeneIDi | 975 |
UCSCi | uc057xxn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124057 Genomic DNA No translation available. AC129929 Genomic DNA No translation available. |
RefSeqi | NP_001284578.1, NM_001297649.1 XP_016874087.1, XM_017018598.1 |
3D structure databases
SMRi | E9PJK1 |
ModBasei | Search... |
PTM databases
SwissPalmi | E9PJK1 |
Proteomic databases
MaxQBi | E9PJK1 |
PRIDEi | E9PJK1 |
ProteomicsDBi | 21166 |
Protocols and materials databases
Antibodypediai | 1570, 1272 antibodies |
DNASUi | 975 |
Genome annotation databases
Ensembli | ENST00000492627; ENSP00000437242; ENSG00000110651 ENST00000526072; ENSP00000431780; ENSG00000110651 |
GeneIDi | 975 |
UCSCi | uc057xxn.1, human |
Organism-specific databases
CTDi | 975 |
HGNCi | HGNC:1701, CD81 |
OpenTargetsi | ENSG00000110651 |
VEuPathDBi | HostDB:ENSG00000110651.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158805 |
HOGENOMi | CLU_055524_10_1_1 |
Miscellaneous databases
BioGRID-ORCSi | 975, 15 hits in 996 CRISPR screens |
ChiTaRSi | CD81, human |
GenomeRNAii | 975 |
Gene expression databases
Bgeei | ENSG00000110651, Expressed in stromal cell of endometrium and 243 other tissues |
ExpressionAtlasi | E9PJK1, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PJK1_HUMAN | |
Accessioni | E9PJK1Primary (citable) accession number: E9PJK1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |