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Protein
Submitted name:

Calpain-1 catalytic subunit

Gene

CAPN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain-1 catalytic subunitImported
Gene namesi
Name:CAPN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000014216.15
HGNCiHGNC:1476 CAPN1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000014216

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PJJ3
PRIDEiE9PJJ3

Expressioni

Gene expression databases

BgeeiENSG00000014216 Expressed in 213 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiE9PJJ3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PJJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 135Calpain catalyticInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971

Family and domain databases

InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR029643 CAPN1
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF284 PTHR10183:SF284, 1 hit
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

E9PJJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEIITPVY CTGVSAQVQK QRARELGLGR HENAIKYLGQ DYEQLRVRCL
60 70 80 90 100
QSGTLFRDEA FPPVPQSLGY KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD
110 120 130
GATRTDICQG ALGDCWLLAA IASLTLNDTL LHRVV
Length:135
Mass (Da):15,022
Last modified:October 5, 2016 - v8
Checksum:i1EC8751A39DB9C5B
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P07384CAN1_HUMAN
Calpain-1 catalytic subunit
CAPN1 CANPL1, PIG30
714Annotation score:
E9PRM1E9PRM1_HUMAN
Calpain-1 catalytic subunit
CAPN1
201Annotation score:
E9PL37E9PL37_HUMAN
Calpain-1 catalytic subunit
CAPN1
191Annotation score:
E9PQB3E9PQB3_HUMAN
Calpain-1 catalytic subunit
CAPN1
191Annotation score:
E9PSA6E9PSA6_HUMAN
Calpain-1 catalytic subunit
CAPN1
163Annotation score:
E9PMC6E9PMC6_HUMAN
Calpain-1 catalytic subunit
CAPN1
152Annotation score:
E9PLC9E9PLC9_HUMAN
Calpain-1 catalytic subunit
CAPN1
148Annotation score:
E9PLX0E9PLX0_HUMAN
Calpain-1 catalytic subunit
CAPN1
122Annotation score:
E9PJA6E9PJA6_HUMAN
Calpain-1 catalytic subunit
CAPN1
161Annotation score:
E9PIA9E9PIA9_HUMAN
Calpain-1 catalytic subunit
CAPN1
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei135Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003068 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000534373; ENSP00000431793; ENSG00000014216
UCSCiuc058dhq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003068 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PJJ3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PJJ3
PRIDEiE9PJJ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000534373; ENSP00000431793; ENSG00000014216
UCSCiuc058dhq.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000014216.15
HGNCiHGNC:1476 CAPN1
OpenTargetsiENSG00000014216
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971

Miscellaneous databases

ChiTaRSiCAPN1 human

Gene expression databases

BgeeiENSG00000014216 Expressed in 213 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiE9PJJ3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR029643 CAPN1
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF284 PTHR10183:SF284, 1 hit
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PJJ3_HUMAN
AccessioniPrimary (citable) accession number: E9PJJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 63 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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