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Entry version 46 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Nuclear pore complex-interacting protein family member B6

Gene

NPIPB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex-interacting protein family member B6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPIPB6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198156.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:37454 NPIPB6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_E9PJ23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198156

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NPIPB6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004239211 – 425Nuclear pore complex-interacting protein family member B6Add BLAST425

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9PJ23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PJ23

PRoteomics IDEntifications database

More...
PRIDEi
E9PJ23

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20996

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198156 Expressed in 88 organ(s), highest expression level in left testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PJ23 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PJ23 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011188
HPA053611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PJ23

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PJ23

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi265 – 360Pro-richAdd BLAST96

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPIP family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00540000072033

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PJ23

Database of Orthologous Groups

More...
OrthoDBi
1680677at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PJ23

TreeFam database of animal gene trees

More...
TreeFami
TF333389

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009443 NPIP

The PANTHER Classification System

More...
PANTHERi
PTHR15438 PTHR15438, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PJ23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLSIVLTP QFLSHDQSQL TKELQQHVKS VTCPCEYLRK VINSLAVYRH
60 70 80 90 100
RETDFGVGVR DHPGQHGKTP SPQKLDNLII IIIGFLRRYT FNILFCTSCL
110 120 130 140 150
CVSFLKTIFW SRNGHDGSMD VQQRAWRSNR SRQKGLRSIC MHTKKRVSSF
160 170 180 190 200
RGNKIGLKDV ITLRRHVETK VRAKIRKRKV TTKINRHDKI NGKRKTARKQ
210 220 230 240 250
KMFQRAQELR RRAEDYHKCK IPPSARKPLC NWVRMVAAEH RHSSGLPYWP
260 270 280 290 300
YLTAETLKNR MGRQPPPPTQ QHSITDNSLS LKTPTECLLT PLPPSVDDNI
310 320 330 340 350
KECPLAPLPP SPLPPSVDDN LKECLFVPLP PSPLPPSVDD NLKTPPLATQ
360 370 380 390 400
EAEVEKPPKP KRWRVDEVEQ SPKPKRRRVD EVEQSPKPKR QREAEAQQLP
410 420
KPKRRRLSKL RTRHCTQAWA IRINP
Length:425
Mass (Da):49,162
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FF21B299D4F7E29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS57E9PS57_HUMAN
Nuclear pore complex-interacting pr...
NPIPB6
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC138894 Genomic DNA No translation available.
AC138904 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61892.1

NCBI Reference Sequences

More...
RefSeqi
NP_001269453.1, NM_001282524.1
XP_011544231.1, XM_011545929.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.726467

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000532254; ENSP00000431871; ENSG00000198156

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
728741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:728741

UCSC genome browser

More...
UCSCi
uc010vcr.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138894 Genomic DNA No translation available.
AC138904 Genomic DNA No translation available.
CCDSiCCDS61892.1
RefSeqiNP_001269453.1, NM_001282524.1
XP_011544231.1, XM_011545929.2
UniGeneiHs.726467

3D structure databases

ProteinModelPortaliE9PJ23
SMRiE9PJ23
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiNPIPB6

Proteomic databases

EPDiE9PJ23
PaxDbiE9PJ23
PRIDEiE9PJ23
ProteomicsDBi20996

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532254; ENSP00000431871; ENSG00000198156
GeneIDi728741
KEGGihsa:728741
UCSCiuc010vcr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
728741
EuPathDBiHostDB:ENSG00000198156.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NPIPB6
HGNCiHGNC:37454 NPIPB6
HPAiHPA011188
HPA053611
neXtProtiNX_E9PJ23
OpenTargetsiENSG00000198156

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00540000072033
InParanoidiE9PJ23
OrthoDBi1680677at2759
PhylomeDBiE9PJ23
TreeFamiTF333389

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NPIPB6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
728741

Protein Ontology

More...
PROi
PR:E9PJ23

Gene expression databases

BgeeiENSG00000198156 Expressed in 88 organ(s), highest expression level in left testis
ExpressionAtlasiE9PJ23 baseline and differential
GenevisibleiE9PJ23 HS

Family and domain databases

InterProiView protein in InterPro
IPR009443 NPIP
PANTHERiPTHR15438 PTHR15438, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPIB6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PJ23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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