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Protein
Submitted name:

ADP-ribosylation factor GTPase-activating protein 2

Gene

ARFGAP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
ADP-ribosylation factor GTPase-activating protein 2Imported
Gene namesi
Name:ARFGAP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149182.14
HGNCiHGNC:13504 ARFGAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149182

PTM / Processingi

Proteomic databases

MaxQBiE9PIY6
PeptideAtlasiE9PIY6
PRIDEiE9PIY6

Expressioni

Gene expression databases

BgeeiENSG00000149182 Expressed in 224 organ(s), highest expression level in skin of leg
ExpressionAtlasiE9PIY6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PIY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 117Arf-GAPInterPro annotationAdd BLAST107

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili285 – 319Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0706 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00390000005436

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.iShow all

E9PIY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS
60 70 80 90 100
GVHRSLGVHL SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN
110 120 130 140 150
DANTKYNSRA AQMYREKIRQ LGSAALARHG TDLWIDNMSS AVPNHSPEKK
160 170 180 190 200
DSDFFTEHTQ EWLTEASVIW PPFQPPAWDA PATEPSGTQQ PAPSTESSGL
210 220 230 240 250
AQPEHGPNTD LLGTSPKASL ELKSSIIGKK KPAAAKKGLG AKKGLGAQKV
260 270 280 290 300
SSQSFSEIER QAQVAEKLRE QQAADAKKQA EESMVASMRL AYQELQIDRK
310 320
KEEKKLQNLE GKKREQAERL GMGLVSR
Length:327
Mass (Da):36,061
Last modified:April 5, 2011 - v1
Checksum:iB76231394E35DB88
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N6H7ARFG2_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2 ZNF289, Nbla10535
521Annotation score:
E9PN48E9PN48_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
252Annotation score:
A0A0D9SF70A0A0D9SF70_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2 ZNF289, hCG_1811553
385Annotation score:
G5E9L0G5E9L0_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
493Annotation score:
E9PQP3E9PQP3_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
274Annotation score:
E9PNY8E9PNY8_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
110Annotation score:
E9PM18E9PM18_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
70Annotation score:
E9PM63E9PM63_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
94Annotation score:
E9PMR9E9PMR9_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
89Annotation score:
H0YDN9H0YDN9_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
237Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei327Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090589 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000525398; ENSP00000431939; ENSG00000149182
UCSCiuc058bai.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090589 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PIY6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9PIY6
PeptideAtlasiE9PIY6
PRIDEiE9PIY6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525398; ENSP00000431939; ENSG00000149182
UCSCiuc058bai.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000149182.14
HGNCiHGNC:13504 ARFGAP2
OpenTargetsiENSG00000149182
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0706 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00390000005436

Miscellaneous databases

ChiTaRSiARFGAP2 human

Gene expression databases

BgeeiENSG00000149182 Expressed in 224 organ(s), highest expression level in skin of leg
ExpressionAtlasiE9PIY6 baseline and differential

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PIY6_HUMAN
AccessioniPrimary (citable) accession number: E9PIY6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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