UniProtKB - E9PIE8 (E9PIE8_HUMAN)
Protein
Voltage-dependent R-type calcium channel subunit alpha
Gene
CACNA1E
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.UniRule annotation
GO - Molecular functioni
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent R-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1EImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1392, CACNA1E |
VEuPathDBi | HostDB:ENSG00000198216.10 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 275 – 295 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 307 – 325 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 366 – 388 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 440 – 461 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 473 – 495 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000198216, Expressed in caudate nucleus and 88 other tissues |
ExpressionAtlasi | E9PIE8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 234 – 506 | Ion_transInterPro annotationAdd BLAST | 273 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 155 – 185 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 176 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155601 |
HOGENOMi | CLU_056877_0_0_1 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR005449, VDCC_R_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF5, PTHR45628:SF5, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit |
PRINTSi | PR00167, CACHANNEL PR01633, RVDCCALPHA1 |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PIE8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVPEMRGLSP DRRLPEPAPC PAAGSPEPRS AGRRQRHVLA LPEEEAWRPQ
60 70 80 90 100
QCALLEADAS DEVGMLPASP RAASGFDNFF QVQEGEGQGW EGAMALEAGS
110 120 130 140 150
SPFLPVSPEV MKRRRGGLIE QRDIIKAHEA HKMQSTPQAR RKEWEMARFG
160 170 180 190 200
EAVVARPGSG DGDSDQSRNR QGTPVPASGQ AAAYKQTKAQ RARTMALYNP
210 220 230 240 250
IPVRQNCFTV NRSLFIFGED NIVRKYAKKL IDWPPFEYMI LATIIANCIV
260 270 280 290 300
LALEQHLPED DKTPMSRRLE KTEPYFIGIF CFEAGIKIVA LGFIFHKGSY
310 320 330 340 350
LRNGWNVMDF IVVLSGILAT AGTHFNTHVD LRTLRAVRVL RPLKLVSGIP
360 370 380 390 400
SLQIVLKSIM KAMVPLLQIG LLLFFAILMF AIIGLEFYSG KLHRACFMNN
410 420 430 440 450
SGILEGFDPP HPCGVQGCPA GYECKDWIGP NDGITQFDNI LFAVLTVFQC
460 470 480 490 500
ITMEGWTTVL YNTNDALGAT WNWLYFIPLI IIGSFFVLNL VLGVLSGEFA
510 520 530 540 550
KERERVENRR AFMKLRRQQQ IERELNGYRA WIDKAEEVML AEENKNAGTS
560 570 580
ALEVLRRATI KRSRTEAMTR DSSDEHCVDI SSV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ15878 | CAC1E_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E CACH6, CACNL1A6 | 2,313 | Annotation score: | ||
F8W9Z1 | F8W9Z1_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E | 2,294 | Annotation score: | ||
J3KP11 | J3KP11_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E | 2,312 | Annotation score: | ||
A0A2R8Y7W1 | A0A2R8Y7W1_HUMAN | Voltage-dependent R-type calcium ch... | CACNA1E | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 583 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL160059 Genomic DNA No translation available. AL161734 Genomic DNA No translation available. AL356500 Genomic DNA No translation available. AL359270 Genomic DNA No translation available. AL590624 Genomic DNA No translation available. AL590998 Genomic DNA No translation available. KF455083 Genomic DNA No translation available. KF455110 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000524607; ENSP00000432038; ENSG00000198216 |
UCSCi | uc001gov.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL160059 Genomic DNA No translation available. AL161734 Genomic DNA No translation available. AL356500 Genomic DNA No translation available. AL359270 Genomic DNA No translation available. AL590624 Genomic DNA No translation available. AL590998 Genomic DNA No translation available. KF455083 Genomic DNA No translation available. KF455110 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9PIE8 |
PRIDEi | E9PIE8 |
ProteomicsDBi | 20787 |
Protocols and materials databases
Antibodypediai | 34433, 121 antibodies |
Genome annotation databases
Ensembli | ENST00000524607; ENSP00000432038; ENSG00000198216 |
UCSCi | uc001gov.4, human |
Organism-specific databases
HGNCi | HGNC:1392, CACNA1E |
OpenTargetsi | ENSG00000198216 |
VEuPathDBi | HostDB:ENSG00000198216.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155601 |
HOGENOMi | CLU_056877_0_0_1 |
Miscellaneous databases
ChiTaRSi | CACNA1E, human |
Gene expression databases
Bgeei | ENSG00000198216, Expressed in caudate nucleus and 88 other tissues |
ExpressionAtlasi | E9PIE8, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR005449, VDCC_R_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF5, PTHR45628:SF5, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit |
PRINTSi | PR00167, CACHANNEL PR01633, RVDCCALPHA1 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PIE8_HUMAN | |
Accessioni | E9PIE8Primary (citable) accession number: E9PIE8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |