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Protein
Submitted name:

Phosphatidylinositol-binding clathrin assembly protein

Gene

PICALM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol-binding clathrin assembly proteinImported
Gene namesi
Name:PICALMImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000073921.17
HGNCiHGNC:15514 PICALM

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000073921

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PI56
PRIDEiE9PI56

Expressioni

Gene expression databases

BgeeiENSG00000073921 Expressed in 234 organ(s), highest expression level in corpus callosum
ExpressionAtlasiE9PI56 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94ENTHInterPro annotationAdd BLAST94

Phylogenomic databases

eggNOGiKOG0251 Eukaryota
ENOG410XQ90 LUCA
GeneTreeiENSGT00390000008805

Family and domain databases

Gene3Di1.20.58.150, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR011417 ANTH_dom
IPR014712 Clathrin_AP_dom2
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR030412 PICALM
PANTHERiPTHR22951:SF16 PTHR22951:SF16, 1 hit
PfamiView protein in Pfam
PF07651 ANTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

E9PI56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVNIPQLAD SLFERTTNSS WVVVFKSLIT THHLMVYGNE RFIQYLASRN
60 70 80 90 100
TLFNLSNFLD KSGLQGYDMS TFIRRYSRYL NEKAVSYRQV AFDFTKVKRG
110 120 130 140
ADGVMRTMNT EKLLKTVPII QNQMDALLDF NVNSNELTNG VINAAFM
Length:147
Mass (Da):16,936
Last modified:October 5, 2016 - v8
Checksum:iC6C7A574724072EE
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13492PICAL_HUMAN
Phosphatidylinositol-binding clathr...
PICALM CALM
652Annotation score:
H0YEF7H0YEF7_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
302Annotation score:
H0YD48H0YD48_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
264Annotation score:
H0YCY1H0YCY1_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
244Annotation score:
H0YEH1H0YEH1_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
308Annotation score:
E9PLJ8E9PLJ8_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
185Annotation score:
E9PKP6E9PKP6_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
148Annotation score:
E9PK13E9PK13_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
105Annotation score:
H0YE97H0YE97_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
134Annotation score:
H0YEY8H0YEY8_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
215Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei147Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000767 Genomic DNA No translation available.
KF455430 Genomic DNA No translation available.
KF511164 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000525162; ENSP00000436508; ENSG00000073921
UCSCiuc058gfl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000767 Genomic DNA No translation available.
KF455430 Genomic DNA No translation available.
KF511164 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PI56
PRIDEiE9PI56

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525162; ENSP00000436508; ENSG00000073921
UCSCiuc058gfl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000073921.17
HGNCiHGNC:15514 PICALM
OpenTargetsiENSG00000073921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0251 Eukaryota
ENOG410XQ90 LUCA
GeneTreeiENSGT00390000008805

Miscellaneous databases

ChiTaRSiPICALM human

Gene expression databases

BgeeiENSG00000073921 Expressed in 234 organ(s), highest expression level in corpus callosum
ExpressionAtlasiE9PI56 baseline and differential

Family and domain databases

Gene3Di1.20.58.150, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR011417 ANTH_dom
IPR014712 Clathrin_AP_dom2
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR030412 PICALM
PANTHERiPTHR22951:SF16 PTHR22951:SF16, 1 hit
PfamiView protein in Pfam
PF07651 ANTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PI56_HUMAN
AccessioniPrimary (citable) accession number: E9PI56
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 52 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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