UniProtKB - E9PHY0 (E9PHY0_HUMAN)
Protein
Submitted name:
Lysosomal acid phosphatase
Gene
ACP2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Lysosomal acid phosphataseImported |
Gene namesi | Name:ACP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134575.9 |
HGNCi | HGNC:123, ACP2 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 318 – 341 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_5003242846 | 31 – 360 | Sequence analysisAdd BLAST | 330 |
Proteomic databases
MaxQBi | E9PHY0 |
PeptideAtlasi | E9PHY0 |
PRIDEi | E9PHY0 |
ProteomicsDBi | 20624 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134575, Expressed in right lobe of liver and 232 other tissues |
ExpressionAtlasi | E9PHY0, baseline and differential |
Family & Domainsi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158446 |
OrthoDBi | 1221585at2759 |
Family and domain databases
CDDi | cd07061, HP_HAP_like, 1 hit |
Gene3Di | 3.40.50.1240, 2 hits |
InterProi | View protein in InterPro IPR033379, Acid_Pase_AS IPR000560, His_Pase_clade-2 IPR029033, His_PPase_superfam |
Pfami | View protein in Pfam PF00328, His_Phos_2, 2 hits |
SUPFAMi | SSF53254, SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616, HIS_ACID_PHOSPHAT_1, 1 hit PS00778, HIS_ACID_PHOSPHAT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
E9PHY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT
60 70 80 90 100
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV
110 120 130 140 150
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR
160 170 180 190 200
QTHGLRLPPW ASPQTMQRLS RLKDFSFRFL FGIYQQAEKA RLQGGVLLAQ
210 220 230 240 250
IRKNLTLMAT TSQLPKLLVY SAHDTTLVAL QMALDVYNGE QAPYASCHIF
260 270 280 290 300
ELYQEDSGNF SVEMYFRNES DKAPWPLSLP GCPHRCPLQD FLRLTEPVVP
310 320 330 340 350
KDWQQECQLA SGPADTEVIV ALAVCGSILF LLIVLLLTVL FRMQAQPPGY
360
RHVADGEDHA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP11117 | PPAL_HUMAN | Lysosomal acid phosphatase | ACP2 | 423 | Annotation score: | ||
A0A5F9ZHR7 | A0A5F9ZHR7_HUMAN | Lysosomal acid phosphatase | ACP2 | 434 | Annotation score: | ||
B7Z7D2 | B7Z7D2_HUMAN | Lysosomal acid phosphatase | ACP2 | 391 | Annotation score: | ||
E9PQY3 | E9PQY3_HUMAN | Lysosomal acid phosphatase | ACP2 | 395 | Annotation score: | ||
B7Z6U3 | B7Z6U3_HUMAN | Lysosomal acid phosphatase | ACP2 | 162 | Annotation score: | ||
A0A5F9ZH40 | A0A5F9ZH40_HUMAN | Lysosomal acid phosphatase | ACP2 | 160 | Annotation score: | ||
A0A5F9ZH82 | A0A5F9ZH82_HUMAN | Lysosomal acid phosphatase | ACP2 | 305 | Annotation score: | ||
A0A5F9ZI20 | A0A5F9ZI20_HUMAN | Lysosomal acid phosphatase | ACP2 | 151 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018410 Genomic DNA No translation available. |
RefSeqi | NP_001289420.1, NM_001302491.1 |
Genome annotation databases
Ensembli | ENST00000529444; ENSP00000436658; ENSG00000134575 |
GeneIDi | 53 |
UCSCi | uc010rhg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018410 Genomic DNA No translation available. |
RefSeqi | NP_001289420.1, NM_001302491.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E9PHY0 |
PeptideAtlasi | E9PHY0 |
PRIDEi | E9PHY0 |
ProteomicsDBi | 20624 |
Protocols and materials databases
Antibodypediai | 26620, 103 antibodies |
Genome annotation databases
Ensembli | ENST00000529444; ENSP00000436658; ENSG00000134575 |
GeneIDi | 53 |
UCSCi | uc010rhg.3, human |
Organism-specific databases
CTDi | 53 |
EuPathDBi | HostDB:ENSG00000134575.9 |
HGNCi | HGNC:123, ACP2 |
NIAGADSi | ENSG00000134575 |
OpenTargetsi | ENSG00000134575 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158446 |
OrthoDBi | 1221585at2759 |
Miscellaneous databases
BioGRID-ORCSi | 53, 4 hits in 844 CRISPR screens |
ChiTaRSi | ACP2, human |
GenomeRNAii | 53 |
Gene expression databases
Bgeei | ENSG00000134575, Expressed in right lobe of liver and 232 other tissues |
ExpressionAtlasi | E9PHY0, baseline and differential |
Family and domain databases
CDDi | cd07061, HP_HAP_like, 1 hit |
Gene3Di | 3.40.50.1240, 2 hits |
InterProi | View protein in InterPro IPR033379, Acid_Pase_AS IPR000560, His_Pase_clade-2 IPR029033, His_PPase_superfam |
Pfami | View protein in Pfam PF00328, His_Phos_2, 2 hits |
SUPFAMi | SSF53254, SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616, HIS_ACID_PHOSPHAT_1, 1 hit PS00778, HIS_ACID_PHOSPHAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PHY0_HUMAN | |
Accessioni | E9PHY0Primary (citable) accession number: E9PHY0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |