UniProtKB - E9PHN6 (E9PHN6_HUMAN)
Protein
Glutathione S-transferase
Gene
GSTM2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.5.1.18UniRule annotation
GO - Molecular functioni
- glutathione transferase activity Source: UniProtKB-EC
Keywordsi
Molecular function | TransferaseUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GSTM2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4634 GSTM2 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- intercellular bridge Source: HPA
PTM / Processingi
Proteomic databases
jPOSTi | E9PHN6 |
MaxQBi | E9PHN6 |
PeptideAtlasi | E9PHN6 |
PRIDEi | E9PHN6 |
ProteomicsDBi | 20572 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213366 Expressed in 88 organ(s), highest expression level in endocervix |
ExpressionAtlasi | E9PHN6 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 88 | GST N-terminalInterPro annotationAdd BLAST | 88 | |
Domaini | 90 – 193 | GST C-terminalInterPro annotationAdd BLAST | 104 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IN5J Eukaryota ENOG4110YU0 LUCA |
GeneTreei | ENSGT00940000155416 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR004045 Glutathione_S-Trfase_N IPR004046 GST_C IPR003081 GST_mu IPR036249 Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043 GST_C, 1 hit PF02798 GST_N, 1 hit |
PRINTSi | PR01267 GSTRNSFRASEM |
SUPFAMi | SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405 GST_CTER, 1 hit PS50404 GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9PHN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL
110 120 130 140 150
ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG
160 170 180 190
DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEV FPL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP28161 | GSTM2_HUMAN | Glutathione S-transferase Mu 2 | GSTM2 GST4 | 218 | Annotation score: | ||
F6XZQ7 | F6XZQ7_HUMAN | Glutathione S-transferase | GSTM2 | 220 | Annotation score: | ||
E9PLF1 | E9PLF1_HUMAN | Glutathione S-transferase Mu 2 | GSTM2 | 147 | Annotation score: | ||
E9PHN7 | E9PHN7_HUMAN | Glutathione S-transferase Mu 2 | GSTM2 | 181 | Annotation score: | ||
E9PGV1 | E9PGV1_HUMAN | Glutathione S-transferase Mu 2 | GSTM2 | 87 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC000031 Genomic DNA No translation available. AC000032 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000369829; ENSP00000358844; ENSG00000213366 |
UCSCi | uc057jbg.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC000031 Genomic DNA No translation available. AC000032 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PHN6 |
ModBasei | Search... |
Proteomic databases
jPOSTi | E9PHN6 |
MaxQBi | E9PHN6 |
PeptideAtlasi | E9PHN6 |
PRIDEi | E9PHN6 |
ProteomicsDBi | 20572 |
Genome annotation databases
Ensembli | ENST00000369829; ENSP00000358844; ENSG00000213366 |
UCSCi | uc057jbg.1 human |
Organism-specific databases
HGNCi | HGNC:4634 GSTM2 |
OpenTargetsi | ENSG00000213366 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IN5J Eukaryota ENOG4110YU0 LUCA |
GeneTreei | ENSGT00940000155416 |
Miscellaneous databases
ChiTaRSi | GSTM2 human |
Gene expression databases
Bgeei | ENSG00000213366 Expressed in 88 organ(s), highest expression level in endocervix |
ExpressionAtlasi | E9PHN6 baseline and differential |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR004045 Glutathione_S-Trfase_N IPR004046 GST_C IPR003081 GST_mu IPR036249 Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043 GST_C, 1 hit PF02798 GST_N, 1 hit |
PRINTSi | PR01267 GSTRNSFRASEM |
SUPFAMi | SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405 GST_CTER, 1 hit PS50404 GST_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PHN6_HUMAN | |
Accessioni | E9PHN6Primary (citable) accession number: E9PHN6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | November 13, 2019 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |