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Entry version 80 (02 Jun 2021)
Sequence version 3 (29 Oct 2014)
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Protein
Submitted name:

Dystonin

Gene

DST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi5124 – 5135PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi5160 – 5171PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DystoninImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1090, DST

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000151914.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000151914

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
E9PHM6

PRoteomics IDEntifications database

More...
PRIDEi
E9PHM6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20567

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9PHM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151914, Expressed in corpus callosum and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PHM6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 138Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini151 – 255Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini887 – 944SH3InterPro annotationAdd BLAST58
Domaini5111 – 5146EF-handInterPro annotationAdd BLAST36
Domaini5147 – 5182EF-handInterPro annotationAdd BLAST36
Domaini5187 – 5265GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5289 – 5338DisorderedSequence analysisAdd BLAST50
Regioni5408 – 5497DisorderedSequence analysisAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili12 – 39Sequence analysisAdd BLAST28
Coiled coili459 – 479Sequence analysisAdd BLAST21
Coiled coili677 – 697Sequence analysisAdd BLAST21
Coiled coili734 – 768Sequence analysisAdd BLAST35
Coiled coili840 – 863Sequence analysisAdd BLAST24
Coiled coili1109 – 1129Sequence analysisAdd BLAST21
Coiled coili1208 – 1242Sequence analysisAdd BLAST35
Coiled coili1418 – 1448Sequence analysisAdd BLAST31
Coiled coili1504 – 1531Sequence analysisAdd BLAST28
Coiled coili1593 – 1613Sequence analysisAdd BLAST21
Coiled coili1637 – 1671Sequence analysisAdd BLAST35
Coiled coili1757 – 1777Sequence analysisAdd BLAST21
Coiled coili1804 – 1824Sequence analysisAdd BLAST21
Coiled coili1853 – 1880Sequence analysisAdd BLAST28
Coiled coili2168 – 2188Sequence analysisAdd BLAST21
Coiled coili2260 – 2287Sequence analysisAdd BLAST28
Coiled coili2415 – 2439Sequence analysisAdd BLAST25
Coiled coili2472 – 2499Sequence analysisAdd BLAST28
Coiled coili2686 – 2720Sequence analysisAdd BLAST35
Coiled coili2727 – 2747Sequence analysisAdd BLAST21
Coiled coili2857 – 2877Sequence analysisAdd BLAST21
Coiled coili2971 – 2998Sequence analysisAdd BLAST28
Coiled coili3018 – 3045Sequence analysisAdd BLAST28
Coiled coili3118 – 3148Sequence analysisAdd BLAST31
Coiled coili3162 – 3200Sequence analysisAdd BLAST39
Coiled coili4108 – 4135Sequence analysisAdd BLAST28
Coiled coili4166 – 4186Sequence analysisAdd BLAST21
Coiled coili4214 – 4258Sequence analysisAdd BLAST45
Coiled coili4360 – 4398Sequence analysisAdd BLAST39
Coiled coili4487 – 4507Sequence analysisAdd BLAST21
Coiled coili4869 – 4899Sequence analysisAdd BLAST31
Coiled coili5077 – 5097Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5301 – 5335Polar residuesSequence analysisAdd BLAST35
Compositional biasi5442 – 5488Polar residuesSequence analysisAdd BLAST47

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155008

Database of Orthologous Groups

More...
OrthoDBi
24858at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 7 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 21 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

E9PHM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGYLSPAAY LYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM
60 70 80 90 100
KVRKHVNDLY EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL
110 120 130 140 150
DYLKRRQVKL VNIRNDDITD GNPKLTLGLI WTIILHFQIS DIHVTGESED
160 170 180 190 200
MSAKERLLLW TQQATEGYAG IRCENFTTCW RDGKLFNAII HKYRPDLIDM
210 220 230 240 250
NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE KSVITYVSSL
260 270 280 290 300
YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VTTMSERTFP
310 320 330 340 350
NNPVELKALY NQYLQFKETE IPPKETEKSK IKRLYKLLEI WIEFGRIKLL
360 370 380 390 400
QGYHPNDIEK EWGKLIIAML EREKALRPEV ERLEMLQQIA NRVQRDSVIC
410 420 430 440 450
EDKLILAGNA LQSDSKRLES GVQFQNEAEI AGYILECENL LRQHVIDVQI
460 470 480 490 500
LIDGKYYQAD QLVQRVAKLR DEIMALRNEC SSVYSKGRIL TTEQTKLMIS
510 520 530 540 550
GITQSLNSGF AQTLHPSLTS GLTQSLTPSL TSSSMTSGLS SGMTSRLTPS
560 570 580 590 600
VTPAYTPGFP SGLVPNFSSG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE
610 620 630 640 650
EEINMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE
660 670 680 690 700
FESSLKEAKI SEIQMTAPLK LTYAEKLHRL ESQYAKLLNT SRNQERHLDT
710 720 730 740 750
LHNFVSRATN ELIWLNEKEE EEVAYDWSER NTNIARKKDY HAELMRELDQ
760 770 780 790 800
KEENIKSVQE IAEQLLLENH PARLTIEAYR AAMQTQWSWI LQLCQCVEQH
810 820 830 840 850
IKENTAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI HKLEDLVQES
860 870 880 890 900
MEEKEELLQY KSTIANLMGK AKTIIQLKPR NSDCPLKTSI PIKAICDYRQ
910 920 930 940 950
IEITIYKDDE CVLANNSHRA KWKVISPTGN EAMVPSVCFT VPPPNKEAVD
960 970 980 990 1000
LANRIEQQYQ NVLTLWHESH INMKSVVSWH YLINEIDRIR ASNVASIKTM
1010 1020 1030 1040 1050
LPGEHQQVLS NLQSRFEDFL EDSQESQVFS GSDITQLEKE VNVCKQYYQE
1060 1070 1080 1090 1100
LLKSAEREEQ EESVYNLYIS EVRNIRLRLE NCEDRLIRQI RTPLERDDLH
1110 1120 1130 1140 1150
ESVFRITEQE KLKKELERLK DDLGTITNKC EEFFSQAAAS SSVPTLRSEL
1160 1170 1180 1190 1200
NVVLQNMNQV YSMSSTYIDK LKTVNLVLKN TQAAEALVKL YETKLCEEEA
1210 1220 1230 1240 1250
VIADKNNIEN LISTLKQWRS EVDEKRQVFH ALEDELQKAK AISDEMFKTY
1260 1270 1280 1290 1300
KERDLDFDWH KEKADQLVER WQNVHVQIDN RLRDLEGIGK SLKYYRDTYH
1310 1320 1330 1340 1350
PLDDWIQQVE TTQRKIQENQ PENSKTLATQ LNQQKMLVSE IEMKQSKMDE
1360 1370 1380 1390 1400
CQKYAEQYSA TVKDYELQTM TYRAMVDSQQ KSPVKRRRMQ SSADLIIQEF
1410 1420 1430 1440 1450
MDLRTRYTAL VTLMTQYIKF AGDSLKRLEE EEKSLEEEKK EHVEKAKELQ
1460 1470 1480 1490 1500
KWVSNISKTL KDAEKAGKPP FSKQKISSEE ISTKKEQLSE ALQTIQLFLA
1510 1520 1530 1540 1550
KHGDKMTDEE RNELEKQVKT LQESYNLLFS ESLKQLQESQ TSGDVKVEEK
1560 1570 1580 1590 1600
IVAERQQEYK EKLQGICDLL TQTENRLIGH QEAFMIGDGT VELKKYQSKQ
1610 1620 1630 1640 1650
EELQKDMQGS AQALAEVVKN TENFLKENGE KLSQEDKALI EQKLNEAKIK
1660 1670 1680 1690 1700
CEQLNLKAEQ SKKELDKVVT TAIKEETEKV AAVKQLEESK TKIENLLDWL
1710 1720 1730 1740 1750
SNVDKDSERA GTKHKQVIEQ NGTHFQEGDG KSAIGEEDEV NGNLLETDVD
1760 1770 1780 1790 1800
GQVGTTQENL NQQYQKVKAQ HEKIISQHQA VIIATQSAQV LLEKQGQYLS
1810 1820 1830 1840 1850
PEEKEKLQKN MKELKVHYET ALAESEKKMK LTHSLQEELE KFDADYTEFE
1860 1870 1880 1890 1900
HWLQQSEQEL ENLEAGADDI NGLMTKLKRQ KSFSEDVISH KGDLRYITIS
1910 1920 1930 1940 1950
GNRVLEAAKS CSKRDGGKVD TSATHREVQR KLDHATDRFR SLYSKCNVLG
1960 1970 1980 1990 2000
NNLKDLVDKY QHYEDASCGL LAGLQACEAT ASKHLSEPIA VDPKNLQRQL
2010 2020 2030 2040 2050
EETKALQGQI SSQQVAVEKL KKTAEVLLDA RGSLLPAKND IQKTLDDIVG
2060 2070 2080 2090 2100
RYEDLSKSVN ERNEKLQITL TRSLSVQDGL DEMLDWMGNV ESSLKEQGQV
2110 2120 2130 2140 2150
PLNSTALQDI ISKNIMLEQD IAGRQSSINA MNEKVKKFME TTDPSTASSL
2160 2170 2180 2190 2200
QAKMKDLSAR FSEASHKHKE TLAKMEELKT KVELFENLSE KLQTFLETKT
2210 2220 2230 2240 2250
QALTEVDVPG KDVTELSQYM QESTSEFLEH KKHLEVLHSL LKEISSHGLP
2260 2270 2280 2290 2300
SDKALVLEKT NNLSKKFKEM EDTIKEKKEA VTSCQEQLDA FQVLVKSLKS
2310 2320 2330 2340 2350
WIKETTKKVP IVQPSFGAED LGKSLEDTKK LQEKWSLKTP EIQKVNNSGI
2360 2370 2380 2390 2400
SLCNLISAVT TPAKAIAAVK SGGAVLNGEG TATNTEEFWA NKGLTSIKKD
2410 2420 2430 2440 2450
MTDISHGYED LGLLLKDKIA ELNTKLSKLQ KAQEESSAMM QWLQKMNKTA
2460 2470 2480 2490 2500
TKWQQTPAPT DTEAVKTQVE QNKSFEAELK QNVNKVQELK DKLTELLEEN
2510 2520 2530 2540 2550
PDTPEAPRWK QMLTEIDSKW QELNQLTIDR QQKLEESSNN LTQFQTVEAQ
2560 2570 2580 2590 2600
LKQWLVEKEL MVSVLGPLSI DPNMLNTQRQ QVQILLQEFA TRKPQYEQLT
2610 2620 2630 2640 2650
AAGQGILSRP GEDPSLRGIV KEQLAAVTQK WDSLTGQLSD RCDWIDQAIV
2660 2670 2680 2690 2700
KSTQYQSLLR SLSDKLSDLD NKLSSSLAVS THPDAMNQQL ETAQKMKQEI
2710 2720 2730 2740 2750
QQEKKQIKVA QALCEDLSAL VKEEYLKAEL SRQLEGILKS FKDVEQKAEN
2760 2770 2780 2790 2800
HVQHLQSACA SSHQFQQMSR DFQAWLDTKK EEQNKSHPIS AKLDVLESLI
2810 2820 2830 2840 2850
KDHKDFSKTL TAQSHMYEKT IAEGENLLLK TQGSEKAALQ LQLNTIKTNW
2860 2870 2880 2890 2900
DTFNKQVKER ENKLKESLEK ALKYKEQVET LWPWIDKCQN NLEEIKFCLD
2910 2920 2930 2940 2950
PAEGENSIAK LKSLQKEMDQ HFGMVELLNN TANSLLSVCE IDKEVVTDEN
2960 2970 2980 2990 3000
KSLIQKVDMV TEQLHSKKFC LENMTQKFKE FQEVSKESKR QLQCAKEQLD
3010 3020 3030 3040 3050
IHDSLGSQAY SNKYLTMLQT QQKSLQALKH QVDLAKRLAQ DLVVEASDSK
3060 3070 3080 3090 3100
GTSDVLLQVE TIAQEHSTLS QQVDEKCSFL ETKLQGIGHF QNTIREMFSQ
3110 3120 3130 3140 3150
FAEFDDELDS MAPVGRDAET LQKQKETIKA FLKKLEALMA SNDNANKTCK
3160 3170 3180 3190 3200
MMLATEETSP DLVGIKRDLE ALSKQCNKLL DRAQAREEQV EGTIKRLEEF
3210 3220 3230 3240 3250
YSKLKEFSIL LQKAEEHEES QGPVGMETET INQQLNMFKV FQKEEIEPLQ
3260 3270 3280 3290 3300
GKQQDVNWLG QGLIQSAAKS TSTQGLEHDL DDVNARWKTL NKKVAQRAAQ
3310 3320 3330 3340 3350
LQEALLHCGR FQDALESLLS WMVDTEELVA NQKPPSAEFK VVKAQIQEQK
3360 3370 3380 3390 3400
LLQRLLDDRK STVEVIKREG EKIATTAEPA DKVKILKQLS LLDSRWEALL
3410 3420 3430 3440 3450
NKAETRNRQL EGISVVAQQF HETLEPLNEW LTTIEKRLVN CEPIGTQASK
3460 3470 3480 3490 3500
LEEQIAQHKA LEDDIINHNK HLHQAVSIGQ SLKVLSSRED KDMVQSKLDF
3510 3520 3530 3540 3550
SQVWYIEIQE KSHSRSELLQ QALCNAKIFG EDEVELMNWL NEVHDKLSKL
3560 3570 3580 3590 3600
SVQDYSTEGL WKQQSELRVL QEDILLRKQN VDQALLNGLE LLKQTTGDEV
3610 3620 3630 3640 3650
LIIQDKLEAI KARYKDITKL STDVAKTLEQ ALQLARRLHS THEELCTWLD
3660 3670 3680 3690 3700
KVEVELLSYE TQVLKGEEAS QAQMRPKELK KEAKNNKALL DSLNEVSSAL
3710 3720 3730 3740 3750
LELVPWRARE GLEKMVAEDN ERYRLVSDTI TQKVEEIDAA ILRSQQFDQA
3760 3770 3780 3790 3800
ADAELSWITE TEKKLMSLGD IRLEQDQTSA QLQVQKTFTM EILRHKDIID
3810 3820 3830 3840 3850
DLVKSGHKIM TACSEEEKQS MKKKLDKVLK NYDTICQINS ERYLQLERAQ
3860 3870 3880 3890 3900
SLVNQFWETY EELWPWLTET QSIISQLPAP ALEYETLRQQ QEEHRQLREL
3910 3920 3930 3940 3950
IAEHKPHIDK MNKTGPQLLE LSPGEGFSIQ EKYVAADTLY SQIKEDVKKR
3960 3970 3980 3990 4000
AVALDEAISQ STQFHDKIDQ ILESLERIVE RLRQPPSISA EVEKIKEQIS
4010 4020 4030 4040 4050
ENKNVSVDME KLQPLYETLK QRGEEMIARS GGTDKDISAK AVQDKLDQMV
4060 4070 4080 4090 4100
FIWENIHTLV EEREAKLLDV MELAEKFWCD HMSLIVTIKD TQDFIRDLED
4110 4120 4130 4140 4150
PGIDPSVVKQ QQEAAETIRE EIDGLQEELD IVINLGSELI AACGEPDKPI
4160 4170 4180 4190 4200
VKKSIDELNS AWDSLNKAWK DRIDKLEEAM QAAVQYQDGL QAVFDWVDIA
4210 4220 4230 4240 4250
GGKLASMSPI GTDLETVKQQ IEELKQFKSE AYQQQIEMER LNHQAELLLK
4260 4270 4280 4290 4300
KVTEESDKHT VQDPLMELKL IWDSLEERII NRQHKLEGAL LALGQFQHAL
4310 4320 4330 4340 4350
DELLAWLTHT EGLLSEQKPV GGDPKAIEIE LAKHHVLQND VLAHQSTVEA
4360 4370 4380 4390 4400
VNKAGNDLIE SSAGEEASNL QNKLEVLNQR WQNVLEKTEQ RKQQLDGALR
4410 4420 4430 4440 4450
QAKGFHGEIE DLQQWLTDTE RHLLASKPLG GLPETAKEQL NVHMEVCAAF
4460 4470 4480 4490 4500
EAKEETYKSL MQKGQQMLAR CPKSAETNID QDINNLKEKW ESVETKLNER
4510 4520 4530 4540 4550
KTKLEEALNL AMEFHNSLQD FINWLTQAEQ TLNVASRPSL ILDTVLFQID
4560 4570 4580 4590 4600
EHKVFANEVN SHREQIIELD KTGTHLKYFS QKQDVVLIKN LLISVQSRWE
4610 4620 4630 4640 4650
KVVQRLVERG RSLDDARKRA KQFHEAWSKL MEWLEESEKS LDSELEIAND
4660 4670 4680 4690 4700
PDKIKTQLAQ HKEFQKSLGA KHSVYDTTNR TGRSLKEKTS LADDNLKLDD
4710 4720 4730 4740 4750
MLSELRDKWD TICGKSVERQ NKLEEALLFS GQFTDALQAL IDWLYRVEPQ
4760 4770 4780 4790 4800
LAEDQPVHGD IDLVMNLIDN HKAFQKELGK RTSSVQALKR SARELIEGSR
4810 4820 4830 4840 4850
DDSSWVKVQM QELSTRWETV CALSISKQTR LEAALRQAEE FHSVVHALLE
4860 4870 4880 4890 4900
WLAEAEQTLR FHGVLPDDED ALRTLIDQHK EFMKKLEEKR AELNKATTMG
4910 4920 4930 4940 4950
DTVLAICHPD SITTIKHWIT IIRARFEEVL AWAKQHQQRL ASALAGLIAK
4960 4970 4980 4990 5000
QELLEALLAW LQWAETTLTD KDKEVIPQEI EEVKALIAEH QTFMEEMTRK
5010 5020 5030 5040 5050
QPDVDKVTKT YKRRAADPSS LQSHIPVLDK GRAGRKRFPA SSLYPSGSQT
5060 5070 5080 5090 5100
QIETKNPRVN LLVSKWQQVW LLALERRRKL NDALDRLEEL REFANFDFDI
5110 5120 5130 5140 5150
WRKKYMRWMN HKKSRVMDFF RRIDKDQDGK ITRQEFIDGI LSSKFPTSRL
5160 5170 5180 5190 5200
EMSAVADIFD RDGDGYIDYY EFVAALHPNK DAYKPITDAD KIEDEVTRQV
5210 5220 5230 5240 5250
AKCKCAKRFQ VEQIGDNKYR FFLGNQFGDS QQLRLVRILR STVMVRVGGG
5260 5270 5280 5290 5300
WMALDEFLVK NDPCRAKGRT NMELREKFIL ADGASQGMAA FRPRGRRSRP
5310 5320 5330 5340 5350
SSRGASPNRS TSVSSQAAQA ASPQVPATTT PKILHPLTRN YGKPWLTNSK
5360 5370 5380 5390 5400
MSTPCKAAEC SDFPVPSAEG TPIQGSKLRL PGYLSGKGFH SGEDSGLITT
5410 5420 5430 5440 5450
AAARVRTQFA DSKKTPSRPG SRAGSKAGSR ASSRRGSDAS DFDISEIQSV
5460 5470 5480 5490
CSDVETVPQT HRPTPRAGSR PSTAKPSKIP TPQRKSPASK LDKSSKR
Length:5,497
Mass (Da):629,787
Last modified:October 29, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBB46088AF623DED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q03001DYST_HUMAN
Dystonin
DST BP230, BP240, BPAG1, DMH, DT
7,570Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9J4F8W9J4_HUMAN
Dystonin
DST
7,461Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QMI7F6QMI7_HUMAN
Dystonin
DST
5,537Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQJ2A0A0U1RQJ2_HUMAN
Dystonin
DST
2,676Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C073A0A494C073_HUMAN
Dystonin
DST
1,347Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1U5A0A494C1U5_HUMAN
Dystonin
DST
625Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETB9E7ETB9_HUMAN
Dystonin
DST
1,479Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0V7Q5T0V7_HUMAN
Dystonin
DST
689Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1D7A0A494C1D7_HUMAN
Dystonin
DST
2,383Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6P0N6Q6P0N6_HUMAN
DST protein
DST
1,143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL096710 Genomic DNA No translation available.
AL137008 Genomic DNA No translation available.
AL512422 Genomic DNA No translation available.
AL512448 Genomic DNA No translation available.
AL590005 Genomic DNA No translation available.
AL590037 Genomic DNA No translation available.
KF458172 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_899236.1, NM_183380.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000421834; ENSP00000400883; ENSG00000151914

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
667

UCSC genome browser

More...
UCSCi
uc021zaz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096710 Genomic DNA No translation available.
AL137008 Genomic DNA No translation available.
AL512422 Genomic DNA No translation available.
AL512448 Genomic DNA No translation available.
AL590005 Genomic DNA No translation available.
AL590037 Genomic DNA No translation available.
KF458172 Genomic DNA No translation available.
RefSeqiNP_899236.1, NM_183380.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiE9PHM6

Proteomic databases

PeptideAtlasiE9PHM6
PRIDEiE9PHM6
ProteomicsDBi20567

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31066, 179 antibodies

The DNASU plasmid repository

More...
DNASUi
667

Genome annotation databases

EnsembliENST00000421834; ENSP00000400883; ENSG00000151914
GeneIDi667
UCSCiuc021zaz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
667
HGNCiHGNC:1090, DST
OpenTargetsiENSG00000151914
VEuPathDBiHostDB:ENSG00000151914.18

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155008
OrthoDBi24858at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
667, 9 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DST, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
667

Gene expression databases

BgeeiENSG00000151914, Expressed in corpus callosum and 246 other tissues
ExpressionAtlasiE9PHM6, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 7 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 21 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 30 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PHM6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PHM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 29, 2014
Last modified: June 2, 2021
This is version 80 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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