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UniProtKB - E9PHA6 (E9PHA6_HUMAN)
Protein
DNA mismatch repair protein
Gene
MSH2
Organism
Homo sapiens (Human)
Status
Functioni
Component of the post-replicative DNA mismatch repair system (MMR).
UniRule annotationGO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- mismatched DNA binding Source: InterPro
GO - Biological processi
- mismatch repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | DNA damage, DNA repairUniRule annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: DNA mismatch repair proteinUniRule annotation |
Gene namesi | Name:MSH2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7325, MSH2 |
VEuPathDBi | HostDB:ENSG00000095002 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- MutSalpha complex Source: UniProtKB-UniRule
- nucleoplasm Source: HPA
Other locations
- chromosome Source: UniProtKB-KW
Keywords - Cellular componenti
ChromosomeARBA annotation, NucleusUniRule annotationARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | E9PHA6 |
PeptideAtlasi | E9PHA6 |
PRIDEi | E9PHA6 |
ProteomicsDBi | 20491 |
Expressioni
Gene expression databases
Bgeei | ENSG00000095002, Expressed in secondary oocyte and 227 other tissues |
ExpressionAtlasi | E9PHA6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 743 – 759 | DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST | 17 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 902 – 921 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 353 – 373 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 478 – 498 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 553 – 576 | Sequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00550000074867 |
OrthoDBi | 138168at2759 |
Family and domain databases
Gene3Di | 3.30.420.110, 1 hit 3.40.1170.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR011184, DNA_mismatch_repair_Msh2 IPR007695, DNA_mismatch_repair_MutS-lik_N IPR000432, DNA_mismatch_repair_MutS_C IPR007861, DNA_mismatch_repair_MutS_clamp IPR007696, DNA_mismatch_repair_MutS_core IPR016151, DNA_mismatch_repair_MutS_N IPR036187, DNA_mismatch_repair_MutS_sf IPR007860, DNA_mmatch_repair_MutS_con_dom IPR032642, Msh2 IPR036678, MutS_con_dom_sf IPR045076, MutS_family IPR027417, P-loop_NTPase |
PANTHERi | PTHR11361, PTHR11361, 1 hit PTHR11361:SF35, PTHR11361:SF35, 1 hit |
Pfami | View protein in Pfam PF01624, MutS_I, 1 hit PF05188, MutS_II, 1 hit PF05192, MutS_III, 1 hit PF05190, MutS_IV, 1 hit PF00488, MutS_V, 1 hit |
PIRSFi | PIRSF005813, MSH2, 1 hit |
SMARTi | View protein in SMART SM00534, MUTSac, 1 hit SM00533, MUTSd, 1 hit |
SUPFAMi | SSF48334, SSF48334, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00486, DNA_MISMATCH_REPAIR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
E9PHA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA
60 70 80 90 100
LLAAREVFKT QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV
110 120 130 140 150
EVYKNRAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSASIGVVGV
160 170 180 190 200
KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECV
210 220 230 240 250
LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD LNRLLKGKKG
260 270 280 290 300
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM
310 320 330 340 350
KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL
360 370 380 390 400
MDKNRIEERL NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN
410 420 430 440 450
LQDCYRLYQG INQLPNVIQA LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF
460 470 480 490 500
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREIMNDLEK KMQSTLISAA
510 520 530 540 550
RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
560 570 580 590 600
FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
610 620 630 640 650
QLDAVVSFAH VSNGAPVPYV RPAILEKGQG RIILKASRHA CVEVQDEIAF
660 670 680 690 700
IPNDVYFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA
710 720 730 740 750
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL
760 770 780 790 800
GRGTSTYDGF GLAWAISEYI ATKIGAFCMF ATHFHELTAL ANQIPTVNNL
810 820 830 840 850
HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPKHV IECAKQKALE
860 870 880 890 900
LEEFQYIGES QGYDIMEPAA KKCYLERENL RVTEPKDQCL ILLTWKRKLR
910 920
GGKRSACSRP ERQNQGSGEL S
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP43246 | MSH2_HUMAN | DNA mismatch repair protein Msh2 | MSH2 | 934 | Annotation score: | ||
A0A2R8Y6P0 | A0A2R8Y6P0_HUMAN | DNA mismatch repair protein | MSH2 hCG_17836 | 924 | Annotation score: | ||
A0A2R8YG02 | A0A2R8YG02_HUMAN | DNA mismatch repair protein | MSH2 | 938 | Annotation score: | ||
A0A2R8YFH0 | A0A2R8YFH0_HUMAN | DNA mismatch repair protein | MSH2 | 918 | Annotation score: | ||
A0A2R8Y713 | A0A2R8Y713_HUMAN | DNA mismatch repair protein Msh2 | MSH2 | 168 | Annotation score: | ||
A0A2R8Y7S8 | A0A2R8Y7S8_HUMAN | DNA mismatch repair protein Msh2 | MSH2 | 558 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079250 Genomic DNA No translation available. AC079775 Genomic DNA No translation available. AC138655 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000406134; ENSP00000384199; ENSG00000095002 |
UCSCi | uc061iyj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079250 Genomic DNA No translation available. AC079775 Genomic DNA No translation available. AC138655 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PHA6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9PHA6 |
PeptideAtlasi | E9PHA6 |
PRIDEi | E9PHA6 |
ProteomicsDBi | 20491 |
Protocols and materials databases
Antibodypediai | 4037, 713 antibodies from 48 providers |
Genome annotation databases
Ensembli | ENST00000406134; ENSP00000384199; ENSG00000095002 |
UCSCi | uc061iyj.1, human |
Organism-specific databases
HGNCi | HGNC:7325, MSH2 |
OpenTargetsi | ENSG00000095002 |
VEuPathDBi | HostDB:ENSG00000095002 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00550000074867 |
OrthoDBi | 138168at2759 |
Miscellaneous databases
ChiTaRSi | MSH2, human |
Gene expression databases
Bgeei | ENSG00000095002, Expressed in secondary oocyte and 227 other tissues |
ExpressionAtlasi | E9PHA6, baseline and differential |
Family and domain databases
Gene3Di | 3.30.420.110, 1 hit 3.40.1170.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR011184, DNA_mismatch_repair_Msh2 IPR007695, DNA_mismatch_repair_MutS-lik_N IPR000432, DNA_mismatch_repair_MutS_C IPR007861, DNA_mismatch_repair_MutS_clamp IPR007696, DNA_mismatch_repair_MutS_core IPR016151, DNA_mismatch_repair_MutS_N IPR036187, DNA_mismatch_repair_MutS_sf IPR007860, DNA_mmatch_repair_MutS_con_dom IPR032642, Msh2 IPR036678, MutS_con_dom_sf IPR045076, MutS_family IPR027417, P-loop_NTPase |
PANTHERi | PTHR11361, PTHR11361, 1 hit PTHR11361:SF35, PTHR11361:SF35, 1 hit |
Pfami | View protein in Pfam PF01624, MutS_I, 1 hit PF05188, MutS_II, 1 hit PF05192, MutS_III, 1 hit PF05190, MutS_IV, 1 hit PF00488, MutS_V, 1 hit |
PIRSFi | PIRSF005813, MSH2, 1 hit |
SMARTi | View protein in SMART SM00534, MUTSac, 1 hit SM00533, MUTSd, 1 hit |
SUPFAMi | SSF48334, SSF48334, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00486, DNA_MISMATCH_REPAIR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PHA6_HUMAN | |
Accessioni | E9PHA6Primary (citable) accession number: E9PHA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |