UniProtKB - E9PGV9 (E9PGV9_HUMAN)
Protein
Submitted name:
ATP-binding cassette sub-family G member 1
Gene
ABCG1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 264 – 271 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
- cholesterol transfer activity Source: InterPro
GO - Biological processi
- cellular response to high density lipoprotein particle stimulus Source: Ensembl
- cholesterol efflux Source: Ensembl
- high-density lipoprotein particle remodeling Source: Ensembl
- intracellular cholesterol transport Source: InterPro
- low-density lipoprotein particle remodeling Source: Ensembl
- negative regulation of lipid storage Source: Ensembl
- positive regulation of cholesterol biosynthetic process Source: Ensembl
- positive regulation of cholesterol efflux Source: Ensembl
- regulation of cholesterol esterification Source: Ensembl
- reverse cholesterol transport Source: Ensembl
Keywordsi
Biological process | TransportARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette sub-family G member 1Imported |
Gene namesi | Name:ABCG1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:73, ABCG1 |
VEuPathDBi | HostDB:ENSG00000160179.18 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endosome
- recycling endosome Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 573 – 590 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 602 – 623 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 643 – 668 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 680 – 704 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 710 – 732 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 744 – 762 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 794 – 816 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | E9PGV9 |
PeptideAtlasi | E9PGV9 |
PRIDEi | E9PGV9 |
ProteomicsDBi | 20404 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160179, Expressed in right adrenal gland cortex and 224 other tissues |
ExpressionAtlasi | E9PGV9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 215 – 463 | ABC transporterInterPro annotationAdd BLAST | 249 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160131 |
PhylomeDBi | E9PGV9 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR020064, ABCG1 IPR043926, ABCG_dom IPR027417, P-loop_NTPase IPR005284, Pigment_permease/Abcg |
PANTHERi | PTHR48041:SF90, PTHR48041:SF90, 1 hit |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 1 hit PF19055, ABC2_membrane_7, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00955, 3a01204, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E9PGV9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAVQQTEHL PACPPARRWS SNFCPESTEG GPSLLGLRDM VRRGWSVCTA
60 70 80 90 100
ILLARLWCLV PTHTFLSEYP EAAEYPHPGW VYWLQMAVAP GHLRAWVMRN
110 120 130 140 150
NVTTNIPSAF SGTLTHEEKA VLTVFTGTAT AVHVQVAALA SAKLESSVFV
160 170 180 190 200
TDCVSCKIEN VCDSALQGKR VPMSGLQGSS IVIMPPSNRP LASAASCTWS
210 220 230 240 250
VQVQGGPHHL GVVAISGKVL SAAHGAGRAY GWGFPGDPME EGYKTLLKGI
260 270 280 290 300
SGKFNSGELV AIMGPSGAGK STLMNILAGY RETGMKGAVL INGLPRDLRC
310 320 330 340 350
FRKVSCYIMQ DDMLLPHLTV QEAMMVSAHL KLQEKDEGRR EMVKEILTAL
360 370 380 390 400
GLLSCANTRT GSLSGGQRKR LAIALELVNN PPVMFFDEPT SGLDSASCFQ
410 420 430 440 450
VVSLMKGLAQ GGRSIICTIH QPSAKLFELF DQLYVLSQGQ CVYRGKVCNL
460 470 480 490 500
VPYLRDLGLN CPTYHNPADF VMEVASGEYG DQNSRLVRAV REGMCDSDHK
510 520 530 540 550
RDLGGDAEVN PFLWHRPSEE VKQTKRLKGL RKDSSSMEGC HSFSASCLTQ
560 570 580 590 600
FCILFKRTFL SIMRDSVLTH LRITSHIGIG LLIGLLYLGI GNEAKKVLSN
610 620 630 640 650
SGFLFFSMLF LMFAALMPTV LTFPLEMGVF LREHLNYWYS LKAYYLAKTM
660 670 680 690 700
ADVPFQIMFP VAYCSIVYWM TSQPSDAVRF VLFAALGTMT SLVAQSLGLL
710 720 730 740 750
IGAASTSLQV ATFVGPVTAI PVLLFSGFFV SFDTIPTYLQ WMSYISYVRY
760 770 780 790 800
GFEGVILSIY GLDREDLHCD IDETCHFQKS EAILRELDVE NAKLYLDFIV
810 820
LGIFFISLRL IAYFVLRYKI RAER
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP45844 | ABCG1_HUMAN | ATP-binding cassette sub-family G m... | ABCG1 ABC8, WHT1 | 678 | Annotation score: | ||
C9JKD9 | C9JKD9_HUMAN | ATP-binding cassette sub-family G m... | ABCG1 | 257 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001622 Genomic DNA No translation available. AP001623 Genomic DNA No translation available. KC877901 Genomic DNA No translation available. KC877905 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000398437; ENSP00000381464; ENSG00000160179 |
UCSCi | uc062akm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001622 Genomic DNA No translation available. AP001623 Genomic DNA No translation available. KC877901 Genomic DNA No translation available. KC877905 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PGV9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9PGV9 |
PeptideAtlasi | E9PGV9 |
PRIDEi | E9PGV9 |
ProteomicsDBi | 20404 |
Protocols and materials databases
Antibodypediai | 23734, 389 antibodies |
Genome annotation databases
Ensembli | ENST00000398437; ENSP00000381464; ENSG00000160179 |
UCSCi | uc062akm.1, human |
Organism-specific databases
HGNCi | HGNC:73, ABCG1 |
OpenTargetsi | ENSG00000160179 |
VEuPathDBi | HostDB:ENSG00000160179.18 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160131 |
PhylomeDBi | E9PGV9 |
Miscellaneous databases
ChiTaRSi | ABCG1, human |
Gene expression databases
Bgeei | ENSG00000160179, Expressed in right adrenal gland cortex and 224 other tissues |
ExpressionAtlasi | E9PGV9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR020064, ABCG1 IPR043926, ABCG_dom IPR027417, P-loop_NTPase IPR005284, Pigment_permease/Abcg |
PANTHERi | PTHR48041:SF90, PTHR48041:SF90, 1 hit |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 1 hit PF19055, ABC2_membrane_7, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00955, 3a01204, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PGV9_HUMAN | |
Accessioni | E9PGV9Primary (citable) accession number: E9PGV9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |