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Protein

Interleukin-12 subunit alpha

Gene

IL12A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • immune response Source: InterPro
  • positive regulation of mononuclear cell proliferation Source: AgBase

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alphaUniRule annotation
Short name:
IL-12AUniRule annotation
Gene namesi
Name:IL12AUniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168811.6
HGNCiHGNC:5969 IL12A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168811

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiE9PGR3

Expressioni

Gene expression databases

BgeeiENSG00000168811 Expressed in 81 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiE9PGR3 baseline and differential

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PGR3
SMRiE9PGR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016906

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR004281 IL-12_alpha
PANTHERiPTHR45311 PTHR45311, 1 hit
PfamiView protein in Pfam
PF03039 IL12, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PGR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL
60 70 80 90 100
DHLSLARNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS
110 120 130 140 150
EEIDHEDITK DKTSTVEACL PLELTKNGSC LASRKTSFMM ALCLSSIYED
160 170 180 190 200
LKMYQVEFKT MNAKLLMDPK RQIFLDQNML AVIDELMQAL NFNSETVPQK
210 220 230
SSLEEPDFYK TKIKLCILLH AFRIRAVTID RVMSYLNAS
Length:239
Mass (Da):26,710
Last modified:April 5, 2011 - v1
Checksum:i3B94D9F4366A263C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P29459IL12A_HUMAN
Interleukin-12 subunit alpha
IL12A NKSF1
219Annotation score:
E7ENE1E7ENE1_HUMAN
Interleukin-12 subunit alpha
IL12A
215Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010370 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000466512; ENSP00000419046; ENSG00000168811
UCSCiuc062pmv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010370 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PGR3
SMRiE9PGR3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9PGR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466512; ENSP00000419046; ENSG00000168811
UCSCiuc062pmv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000168811.6
HGNCiHGNC:5969 IL12A
OpenTargetsiENSG00000168811
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000016906

Gene expression databases

BgeeiENSG00000168811 Expressed in 81 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiE9PGR3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR004281 IL-12_alpha
PANTHERiPTHR45311 PTHR45311, 1 hit
PfamiView protein in Pfam
PF03039 IL12, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PGR3_HUMAN
AccessioniPrimary (citable) accession number: E9PGR3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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