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Protein

Interleukin-12 subunit alpha

Gene

IL12A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • interleukin-12 beta subunit binding Source: AgBase
  • interleukin-12 receptor binding Source: InterPro
  • protein heterodimerization activity Source: AgBase

GO - Biological processi

  • immune response Source: InterPro
  • positive regulation of mononuclear cell proliferation Source: AgBase

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alphaUniRule annotation
Short name:
IL-12AUniRule annotation
Gene namesi
Name:IL12AUniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168811.6
HGNCiHGNC:5969 IL12A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168811

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiE9PGR3

Expressioni

Gene expression databases

BgeeiENSG00000168811
ExpressionAtlasiE9PGR3 baseline and differential

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • interleukin-12 beta subunit binding Source: AgBase
  • interleukin-12 receptor binding Source: InterPro
  • protein heterodimerization activity Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliE9PGR3
SMRiE9PGR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016906

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR004281 IL-12_alpha
PANTHERiPTHR45311 PTHR45311, 1 hit
PfamiView protein in Pfam
PF03039 IL12, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

E9PGR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL
60 70 80 90 100
DHLSLARNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS
110 120 130 140 150
EEIDHEDITK DKTSTVEACL PLELTKNGSC LASRKTSFMM ALCLSSIYED
160 170 180 190 200
LKMYQVEFKT MNAKLLMDPK RQIFLDQNML AVIDELMQAL NFNSETVPQK
210 220 230
SSLEEPDFYK TKIKLCILLH AFRIRAVTID RVMSYLNAS
Length:239
Mass (Da):26,710
Last modified:April 5, 2011 - v1
Checksum:i3B94D9F4366A263C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010370 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000466512; ENSP00000419046; ENSG00000168811
UCSCiuc062pmv.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PGR3_HUMAN
AccessioniPrimary (citable) accession number: E9PGR3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 18, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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