UniProtKB - E9PGM9 (E9PGM9_HUMAN)
Protein
Submitted name:
RNA-binding protein 6
Gene
RBM6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: RNA-binding protein 6Imported |
Gene namesi | Name:RBM6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9903, RBM6 |
VEuPathDBi | HostDB:ENSG00000004534.14 |
PTM / Processingi
Proteomic databases
EPDi | E9PGM9 |
MaxQBi | E9PGM9 |
PeptideAtlasi | E9PGM9 |
PRIDEi | E9PGM9 |
ProteomicsDBi | 20352 |
Expressioni
Gene expression databases
Bgeei | ENSG00000004534, Expressed in endocervix and 240 other tissues |
ExpressionAtlasi | E9PGM9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 324 – 404 | RRMInterPro annotationAdd BLAST | 81 | |
Domaini | 919 – 965 | G-patchInterPro annotationAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 89 – 259 | DisorderedSequence analysisAdd BLAST | 171 | |
Regioni | 281 – 322 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 442 – 522 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 609 – 655 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 695 – 816 | DisorderedSequence analysisAdd BLAST | 122 | |
Regioni | 872 – 974 | DisorderedSequence analysisAdd BLAST | 103 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 844 – 871 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 109 – 156 | PolyampholyteSequence analysisAdd BLAST | 48 | |
Compositional biasi | 174 – 215 | PolyampholyteSequence analysisAdd BLAST | 42 | |
Compositional biasi | 222 – 237 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 299 – 321 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 442 – 456 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 462 – 522 | PolyampholyteSequence analysisAdd BLAST | 61 | |
Compositional biasi | 610 – 639 | PolyampholyteSequence analysisAdd BLAST | 30 | |
Compositional biasi | 640 – 655 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 695 – 732 | PolyampholyteSequence analysisAdd BLAST | 38 | |
Compositional biasi | 740 – 754 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 802 – 816 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 872 – 920 | PolyampholyteSequence analysisAdd BLAST | 49 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157976 |
Family and domain databases
CDDi | cd16163, OCRE_RBM6, 1 hit cd12314, RRM1_RBM6, 1 hit cd12563, RRM2_RBM6, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR041591, OCRE IPR035979, RBD_domain_sf IPR028806, RBM6 IPR035617, RBM6_OCRE IPR034123, RBM6_RRM1 IPR034125, RBM6_RRM2 IPR000504, RRM_dom |
PANTHERi | PTHR13948:SF22, PTHR13948:SF22, 2 hits |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF17780, OCRE, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50102, RRM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
E9PGM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYRGGDGTS MDYRGREAPH MNYRDRDAHA VDFRGRDAPP SDFRGRGTYD
60 70 80 90 100
LDFRGRDGSH ADFRGRDLSD LDFRAREQSR SDFRNRDVSD LDFRDKDGTQ
110 120 130 140 150
VDFRGRGSGT TDLDFRDRDT PHSDFRGRHR SRTDQDFRGR EMGSCMEFKD
160 170 180 190 200
REMPPVDPNI LDYIQPSTQD REHSGMNVNR REESTHDHTI ERPAFGIQKG
210 220 230 240 250
EFEHSETREG ETQGVAFEHE SPADFQNSQS PVQDQDKSQL SGREEQSSDA
260 270 280 290 300
GLFKEEGGLD FLGRQDTDYR SMEYRDVDHR LPGSQMFGYG QSKSFPEGKT
310 320 330 340 350
ARDAQRDLQD QDYRTGPSEE KPSRLIRLSG VPEDATKEEI LNAFRTPDGM
360 370 380 390 400
PVKNLQLKEY NTGYDYGYVC VEFSLLEDAI GCMEANQGTL MIQDKEVTLE
410 420 430 440 450
YVSSLDFWYC KRCKANIGGH RSSCSFCKNP REVTEAKQEL ITYPQPQKTS
460 470 480 490 500
IPAPLEKQPN QPLRPADKEP EPRKREEGQE SRLGHQKREA ERYLPPSRRE
510 520 530 540 550
GPTFRRDRER ESWSGETRQD GESKTIMLKR IYRSTPPEVI VEVLEPYVRL
560 570 580 590 600
TTANVRIIKN RTGPMGHTYG FIDLDSHAEA LRVVKILQNL DPPFSIDGKM
610 620 630 640 650
VAVNLATGKR RNDSGDHSDH MHYYQGKKYF RDRRGGGRNS DWSSDTNRQG
660 670 680 690 700
QQSSSDCYIY DSATGYYYDP LAGTYYDPNT QQEVYVPQDP GLPEEEEIKE
710 720 730 740 750
KKPTSQGKSS SKKEMSKRDG KEKKDRGVTR FQENASEGKA PAEDVFKKPL
760 770 780 790 800
PPTVKKEESP PPPKVVNPLI GLLGEYGGDS DYEEEEEEEQ TPPPQPRTAQ
810 820 830 840 850
PQKREEQTKK ENEEDKLTDW NKLACLLCRR QFPNKEVLIK HQQLSDLHKQ
860 870 880 890 900
NLEIHRKIKQ SEQELAYLER REREGKFKGR GNDRREKLQS FDSPERKRIK
910 920 930 940 950
YSRETDSDRK LVDKEDIDTS SKGGCVQQAT GWRKGTGLGY GHPGLASSEE
960 970 980 990
AEGRMRGPSV GASGRTSKRQ SNETYRDAVR RVMFARYKEL D
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP78332 | RBM6_HUMAN | RNA-binding protein 6 | RBM6 DEF3 | 1,123 | Annotation score: | ||
F8WCA5 | F8WCA5_HUMAN | RNA-binding protein 6 | RBM6 | 697 | Annotation score: | ||
C9J250 | C9J250_HUMAN | RNA-binding protein 6 | RBM6 | 119 | Annotation score: | ||
C9JII0 | C9JII0_HUMAN | RNA-binding protein 6 | RBM6 | 120 | Annotation score: | ||
F8WF63 | F8WF63_HUMAN | RNA-binding protein 6 | RBM6 | 199 | Annotation score: | ||
C9JSL1 | C9JSL1_HUMAN | RNA-binding protein 6 | RBM6 | 156 | Annotation score: | ||
C9JMC8 | C9JMC8_HUMAN | RNA-binding protein 6 | RBM6 | 76 | Annotation score: | ||
F8WCT0 | F8WCT0_HUMAN | RNA-binding protein 6 | RBM6 | 35 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104450 Genomic DNA No translation available. AC105935 Genomic DNA No translation available. |
RefSeqi | XP_005264841.1, XM_005264784.1 XP_006712979.1, XM_006712916.1 |
Genome annotation databases
Ensembli | ENST00000443081; ENSP00000396466; ENSG00000004534 |
GeneIDi | 10180 |
UCSCi | uc062jzp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104450 Genomic DNA No translation available. AC105935 Genomic DNA No translation available. |
RefSeqi | XP_005264841.1, XM_005264784.1 XP_006712979.1, XM_006712916.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | E9PGM9, 1 interactor |
MINTi | E9PGM9 |
Proteomic databases
EPDi | E9PGM9 |
MaxQBi | E9PGM9 |
PeptideAtlasi | E9PGM9 |
PRIDEi | E9PGM9 |
ProteomicsDBi | 20352 |
Protocols and materials databases
Antibodypediai | 13824, 174 antibodies |
Genome annotation databases
Ensembli | ENST00000443081; ENSP00000396466; ENSG00000004534 |
GeneIDi | 10180 |
UCSCi | uc062jzp.1, human |
Organism-specific databases
CTDi | 10180 |
HGNCi | HGNC:9903, RBM6 |
OpenTargetsi | ENSG00000004534 |
VEuPathDBi | HostDB:ENSG00000004534.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157976 |
Miscellaneous databases
BioGRID-ORCSi | 10180, 10 hits in 886 CRISPR screens |
ChiTaRSi | RBM6, human |
GenomeRNAii | 10180 |
Gene expression databases
Bgeei | ENSG00000004534, Expressed in endocervix and 240 other tissues |
ExpressionAtlasi | E9PGM9, baseline and differential |
Family and domain databases
CDDi | cd16163, OCRE_RBM6, 1 hit cd12314, RRM1_RBM6, 1 hit cd12563, RRM2_RBM6, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR041591, OCRE IPR035979, RBD_domain_sf IPR028806, RBM6 IPR035617, RBM6_OCRE IPR034123, RBM6_RRM1 IPR034125, RBM6_RRM2 IPR000504, RRM_dom |
PANTHERi | PTHR13948:SF22, PTHR13948:SF22, 2 hits |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF17780, OCRE, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PGM9_HUMAN | |
Accessioni | E9PGM9Primary (citable) accession number: E9PGM9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |