UniProtKB - E9PGM4 (E9PGM4_HUMAN)
Protein
1,4-alpha-glucan branching enzyme
Gene
GBE1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.ARBA annotation EC:2.4.1.18
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 316 | NucleophileUniRule annotation | 1 | |
Active sitei | 371 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-EC
- 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) Source: UniProtKB-EC
- cation binding Source: InterPro
- hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
GO - Biological processi
- glycogen biosynthetic process Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GBE1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4180, GBE1 |
VEuPathDBi | HostDB:ENSG00000114480.12 |
PTM / Processingi
Proteomic databases
MaxQBi | E9PGM4 |
PeptideAtlasi | E9PGM4 |
PRIDEi | E9PGM4 |
ProteomicsDBi | 20348 |
Expressioni
Gene expression databases
Bgeei | ENSG00000114480, Expressed in adipose tissue and 246 other tissues |
ExpressionAtlasi | E9PGM4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 181 – 527 | AamyInterPro annotationAdd BLAST | 347 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000017040 |
HOGENOMi | CLU_011131_2_2_1 |
OMAi | FMLPLSH |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.1180, 1 hit |
InterProi | View protein in InterPro IPR006048, A-amylase/branching_C IPR037439, Branching_enzy IPR006047, Glyco_hydro_13_cat_dom IPR004193, Glyco_hydro_13_N IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF IPR013783, Ig-like_fold IPR014756, Ig_E-set |
PANTHERi | PTHR43651, PTHR43651, 1 hit |
Pfami | View protein in Pfam PF00128, Alpha-amylase, 1 hit PF02806, Alpha-amylase_C, 1 hit PF02922, CBM_48, 1 hit |
PIRSFi | PIRSF000463, GlgB, 1 hit |
SMARTi | View protein in SMART SM00642, Aamy, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF81296, SSF81296, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
E9PGM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLAKVRYKQ FSQILKNIGE NEGGIDKFSR GYESFGVHRC ADGGLYCKEW
60 70 80 90 100
APGAEGVFLT GDFNGWNPFS YPYKKLDYGK WELYIPPKQN KSVLVPHGSK
110 120 130 140 150
LKVVITSKSG EILYRISPWA KYVVREGDNV NYDWIHWDPE HSYEFKHSRP
160 170 180 190 200
KKPRSLRIYE SHVGISSHEG KVASYKHFTC NVLPRIKGLG YNCIQLMAIM
210 220 230 240 250
EHAYYASFGY QITSFFAASS RYGTPEELQE LVDTAHSMGI IVLLDVVHSH
260 270 280 290 300
ASKNSADGLN MFDGTDSCYF HSGPRGTHDL WDSRLFAYSS WEILRFLLSN
310 320 330 340 350
IRWWLEEYRF DGFRFDGVTS MLYHHHGVGQ GFSGDYSEYF GLQVDEDALT
360 370 380 390 400
YLMLANHLVH TLCPDSITIA EDVSGMPALC SPISQGGGGF DYRLAMAIPD
410 420 430 440 450
KWIQLLKEFK DEDWNMGDIV YTLTNRRYLE KCIAYAESHD QALVGDKSLA
460 470 480 490 500
FWLMDAEMYT NMSVLTPFTP VIDRGIQLHK MIRLITHGLG GEGYLNFMGN
510 520 530 540 550
EFGHPEWLDF PRKGNNESYH YARRQFHLTD DDLLRYKFLN NFDRDMNRLE
560 570 580 590 600
ERYGWLAAPQ AYVSEKHEGN KIIAFERAGL LFIFNFHPSK SYTDYRVGTA
610 620 630 640 650
LPGKFKIVLD SDAAEYGGHQ RLDHSTDFFS EAFEHNGRPY SLLVYIPSRV
660
ALILQNVDLP N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ04446 | GLGB_HUMAN | 1,4-alpha-glucan-branching enzyme | GBE1 | 702 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC017015 Genomic DNA No translation available. AC025029 Genomic DNA No translation available. AC099049 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000489715; ENSP00000419638; ENSG00000114480 |
UCSCi | uc062lra.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC017015 Genomic DNA No translation available. AC025029 Genomic DNA No translation available. AC099049 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E9PGM4 |
PeptideAtlasi | E9PGM4 |
PRIDEi | E9PGM4 |
ProteomicsDBi | 20348 |
Protocols and materials databases
Antibodypediai | 32014, 358 antibodies |
Genome annotation databases
Ensembli | ENST00000489715; ENSP00000419638; ENSG00000114480 |
UCSCi | uc062lra.1, human |
Organism-specific databases
HGNCi | HGNC:4180, GBE1 |
OpenTargetsi | ENSG00000114480 |
VEuPathDBi | HostDB:ENSG00000114480.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000017040 |
HOGENOMi | CLU_011131_2_2_1 |
OMAi | FMLPLSH |
Miscellaneous databases
ChiTaRSi | GBE1, human |
Gene expression databases
Bgeei | ENSG00000114480, Expressed in adipose tissue and 246 other tissues |
ExpressionAtlasi | E9PGM4, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.1180, 1 hit |
InterProi | View protein in InterPro IPR006048, A-amylase/branching_C IPR037439, Branching_enzy IPR006047, Glyco_hydro_13_cat_dom IPR004193, Glyco_hydro_13_N IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF IPR013783, Ig-like_fold IPR014756, Ig_E-set |
PANTHERi | PTHR43651, PTHR43651, 1 hit |
Pfami | View protein in Pfam PF00128, Alpha-amylase, 1 hit PF02806, Alpha-amylase_C, 1 hit PF02922, CBM_48, 1 hit |
PIRSFi | PIRSF000463, GlgB, 1 hit |
SMARTi | View protein in SMART SM00642, Aamy, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PGM4_HUMAN | |
Accessioni | E9PGM4Primary (citable) accession number: E9PGM4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |