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Entry version 65 (22 Apr 2020)
Sequence version 2 (29 Oct 2014)
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Protein
Submitted name:

Dynein heavy chain 12, axonemal

Gene

DNAH12

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dynein heavy chain 12, axonemalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174844.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2943 DNAH12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000174844

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
E9PG32

PeptideAtlas

More...
PeptideAtlasi
E9PG32

PRoteomics IDEntifications database

More...
PRIDEi
E9PG32

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20233

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000174844 Expressed in bronchial epithelial cell and 100 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PG32 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1268 – 1407AAAInterPro annotationAdd BLAST140
Domaini1903 – 2072AAAInterPro annotationAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili343 – 363Sequence analysisAdd BLAST21
Coiled coili602 – 622Sequence analysisAdd BLAST21
Coiled coili635 – 662Sequence analysisAdd BLAST28
Coiled coili731 – 759Sequence analysisAdd BLAST29
Coiled coili2747 – 2812Sequence analysisAdd BLAST66
Coiled coili3725 – 3745Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000154280

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_0_1_1

Identification of Orthologs from Complete Genome Data

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OMAi
ICDYNAS

Database of Orthologous Groups

More...
OrthoDBi
2079at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9PG32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDANKAAIA AEKEALNLKL PPIVHLPENI GVDTPTQSKL LKYRRSKEQQ
60 70 80 90 100
QKINQLVIDG AKRNLDRTLG KRTPLLPPPD YPQTMTSEMK KKGFNYIYMK
110 120 130 140 150
QCVESSPLVP IQQEWLDHML RLIPESLKEG KEREELLESL INEVSSDFEN
160 170 180 190 200
SMKRYLVQSV LVKPPVKSLE DEGGPLPESP VGLDYSNPWH SSYVQARNQI
210 220 230 240 250
FSNLHIIHPT MKMLLDLGYT TFADTVLLDF TGIRAKGPID CESLKTDLSI
260 270 280 290 300
QTRNAEEKIM NTWYPKVINL FTKKEALEGV KPEKLDAFYS CVSTLMSNQL
310 320 330 340 350
KDLLRRTVEG FVKLFDPKDQ QRLPIFKIEL TFDDDKMEFY PTFQDLEDNV
360 370 380 390 400
LSLVERIAEA LQNVQTIPSW LSGTSTPVNL DTELPEHVLH WAVDTLKAAV
410 420 430 440 450
HRNLEGARKH YETYVEKYNW LLDGTAVENI ETFQTEDHTF DEYTEFIEKF
460 470 480 490 500
LSLASEIMLL PQWIHYTMVR LDCEDLKTGL TNKAKAFANI LLNDIASKYR
510 520 530 540 550
KENECICSEF EAIKEHALKV PETTEEMMDL ISYVEKARTV GIEELILRIQ
560 570 580 590 600
ESKRQMSYFL DVFLFPQEDL ALNATVLMWP RKINPIFDEN DELIENAKHK
610 620 630 640 650
KENELMAKRE KLILEIEKES RRMEEFTEFA ELERMQQYVT DVRQLQKRIQ
660 670 680 690 700
ESEEAVQFIN KEEELFKWEL TKYPELDKLK VNIEPYQKFF NFVLKWQRSE
710 720 730 740 750
KRWMDGGFLD LNGESMEADV EEFSREIFKT LKFFQTKLKK ELQEKRKAAR
760 770 780 790 800
KRSLEEEKIE EEPKDNATIT MCSTVMEQIK AFKEYIPTVS ILCNPGMRAR
810 820 830 840 850
HWKQISEIVG YDLTPDSGTT LRKVLKLNLT PYLEQFEVIS AGASKEFSLE
860 870 880 890 900
KAMNTMIGTW EDIAFHISLY RDTGVCILSS VDEIQAILDD QIIKTQTMRG
910 920 930 940 950
SPFIKPFEHE IKAWEDRLIR IQETIDEWLK VQAQWLYLEP IFCSEDIMQQ
960 970 980 990 1000
MPEEGRQFQT VDRHWRDIMK FCAKDPKVLA ATSLTGLLEK LQNCNELLEK
1010 1020 1030 1040 1050
IMKGLNAYLE KKRLFFPRFF FLSNDEMLEI LSETKDPLRV QPHLKKCFEG
1060 1070 1080 1090 1100
IAKLEFLPNL DIKAMYSSEG ERVELIALIS TSAARGAVEK WLIQVEDLML
1110 1120 1130 1140 1150
RSVHDVIAAA RLAYPESARR DWVREWPGQV VLCISQMFWT SETQEVISGG
1160 1170 1180 1190 1200
TEGLKKYYKE LQNQLNEIVE LVRGKLSKQT RTTLGALVTI DVHARDVVMD
1210 1220 1230 1240 1250
MIKMGVSHDT DFLWLAQLRY YWENENARVR IINCNVKYAY EYLGNSPRLV
1260 1270 1280 1290 1300
ITPLTDRCYR TLIGAFYLNL GGAPEGPAGT GKTETTKDLA KALAVQCVVF
1310 1320 1330 1340 1350
NCSDGLDYLA MGKFFKGLAS SGAWACFDEF NRIELEVLSV VAQQILCIQR
1360 1370 1380 1390 1400
AIQQKLVVFV FEGTELKLNP NCFVAITMNP GYAGRSELPD NLKVLFRTVA
1410 1420 1430 1440 1450
MMVPNYALIA EISLYSYGFL NARPLSVKIV MTYRLCSEQL SSQFHYDYGM
1460 1470 1480 1490 1500
RAVKAVLVAA GNLKLKYPNE NEDILLLRSI KDVNEPKFLS HDIPLFNGIT
1510 1520 1530 1540 1550
SDLFPGIKLP EADYHEFLEC AHEACNVHNL QPVKFFLEKI IQTYEMMIVR
1560 1570 1580 1590 1600
HGFMLVGEPF AAKTKVLHVL ADTLTLMNEH GYGEEEKVIY RTVNPKSITM
1610 1620 1630 1640 1650
GQLFGQFDPV SHEWTDGIVA NTFREFALSE TPDRKWVVFD GPIDTLWIES
1660 1670 1680 1690 1700
MNTVLDDNKK LCLMSGEIIQ MSPQMSLIFE TMDLSQASPA TVSRCGMIYL
1710 1720 1730 1740 1750
EPSQLGWEPL VSSWLNSLKG PLCEPEYQAL LRGLFAWLIP PSLNQRKKKC
1760 1770 1780 1790 1800
KELIPTSNSN VVVSLTRLFE VLLCNVVEND PTSKHIRVWI MACFIFSLIW
1810 1820 1830 1840 1850
SIGGSCDTDG RRVFDTFIRL IILGKDDENP VPDSVGKWEC PFDEKGLVYD
1860 1870 1880 1890 1900
YMYELKNKGR WVHWNELIKN TNLGDKQIKI QDIIVPTMDT IRYTFLMDLS
1910 1920 1930 1940 1950
ITYAKPLLFV GPTGTGKSVY VKDKLMNHLE KDQYFPFYIN LSARTSANQV
1960 1970 1980 1990 2000
QNIIMARLDK RRKGVFGPPM GKKCIIFIDD MNMPALEKYG AQPPIELLRQ
2010 2020 2030 2040 2050
FFDCGHWYDL KDTSKITLVD IELIAAMGPP GGGRNPVTPR CIRHFNICSI
2060 2070 2080 2090 2100
NSFSDETMVR IFSSIVAFYL RTHEFPPEYF VIGNQIVNGT MEIYKQSVEN
2110 2120 2130 2140 2150
LLPTPTKSHY TFNLRDFSRV IRGCLLIERD AVANKHTMIR LFVHEVLRVF
2160 2170 2180 2190 2200
YDRLINDDDR RWLFQLTKTV IKDHFKESFH SIFSHLRKQN APVTEEDLRN
2210 2220 2230 2240 2250
LMFGDYMNPD LEGDDRVYIE IPNIHHFSDV VDQCLDEYNQ THKTRMNLVI
2260 2270 2280 2290 2300
FRYVLEHLSR ICRVLKQSGG NALLVGLGGS GRQSLTRLAT SMAKMHIFQP
2310 2320 2330 2340 2350
EISKSYGMNE WREDMKGLLR NVGMKGQKTV FLITDTQIKE EAFLEDIDSV
2360 2370 2380 2390 2400
LNTGEVPNIF AADEKQEVME GVRPVAQAGN KHDELSPLAL FAFFVNRCKD
2410 2420 2430 2440 2450
NLHVVVAFSP IGDAFRNRLR QFPSLINCCT IDWFQSWPED ALERVAVKFL
2460 2470 2480 2490 2500
ETLELTEVEQ QEIVPICKHF HTSIMDLSER FLHELGRHNY VTATSYLELI
2510 2520 2530 2540 2550
GSFRQLLTQK RQAVMEAKQR YMNGLDKLAF AESQVGEMQM ELVELQPKLE
2560 2570 2580 2590 2600
EAKIENANMM QVIEIESVQV EAKRQFVKLD EEIASGKAEE AQALKNECES
2610 2620 2630 2640 2650
DLAEAIPALE AALSALDTLK PADITIVKSM KNPPSGVKLV MAAVCVMKDI
2660 2670 2680 2690 2700
KPEKISDPSG TGGKILDYWG PSKKLLGDMN FLRDLKEYDK DNIPVTVMQK
2710 2720 2730 2740 2750
IRSEYLMNPE FDPPKVAKAS SAAEGLCKWI MAMEVYDRVA KVVAPKKARL
2760 2770 2780 2790 2800
SEAQKSLAET MELLNQKRAE LAEVEHHLEN LQMTFLEKTE EKAALEDQVE
2810 2820 2830 2840 2850
LCAKKLERAS QLIGGLGGEK SRWAQAADDL QITYENLTGD VLVSAGVIAY
2860 2870 2880 2890 2900
LGAFTSGFRQ TCTKDWSMLC KKKKIPCSEE FLLSKTLGDP VKIRAWNIAG
2910 2920 2930 2940 2950
LPTDTFSIDN GVIVNNCRRW PLMIDPQGQA NKWIKNSEKE NQLSVIKLSD
2960 2970 2980 2990 3000
SDYMRTLENC IQFGTPLLLE NVGEELDPSL EPLLLRQTFK QGGIDCIRLG
3010 3020 3030 3040 3050
EVIIEYSFDF KFYITTKLRN PHYMPELATK VSLLNFMITP EGLEDQLLGI
3060 3070 3080 3090 3100
VVAKERPELE EERNALILQS AANKKQLKDI EKKILETLSS SEGNILEDES
3110 3120 3130 3140 3150
AIKVLDSAKM MSNEITKKQQ IAEKTELKIA ESREGYRPIA KHSSVLFFSI
3160 3170 3180 3190 3200
ADLANIDPMY QYSLTWFVNL YINSIHDSNK SKILEKRLRY LNDHFTYNLY
3210 3220 3230 3240 3250
CNICRSLFEK DKLLFSFLLC ANLLLARKEI EYQELMFLLT GGVSLKSAEK
3260 3270 3280 3290 3300
NPDPTWLQDK SWEEICRASE FPAFRGLRQH FCEHIYEWRE IYDSKEPHNA
3310 3320 3330 3340 3350
KFPAPMDKNL NELQKIIILR CLRPDKITPA ITNYVTDKLG KKFVEPPPFD
3360 3370 3380 3390 3400
LTKSYLDSNC TIPLIFVLSP GADPMASLLK FANDKSMSGN KFQAISLGQG
3410 3420 3430 3440 3450
QGPIAAKMIK AAIEEGTWVC LQNCHLAVSW MPMLEKICED FTSETCNSSF
3460 3470 3480 3490 3500
RLWLTSYPSS KFPVTILQNG VKMTNEPPTG LRLNLLQSYL TDPVSDPEFF
3510 3520 3530 3540 3550
KGCRGKELAW EKLLFGVCFF HALVQERKKF GPLGWNIPYG FNESDLRISI
3560 3570 3580 3590 3600
RQLQLFINEY DTIPFEAISY LTGECNYGGR VTDDWDRRLL LTMLADFYNL
3610 3620 3630 3640 3650
YIVENPHYKF SPSGNYFAPP KGTYEDYIEF IKKLPFTQHP EIFGLHENVD
3660 3670 3680 3690 3700
ISKDLQQTKT LFESLLLTQG GSKQTGASGS TDQILLEITK DILNKLPSDF
3710 3720 3730 3740 3750
DIEMALRKYP VRYEESMNTV LVQEMERFNN LIITIRNTLR DLEKAIKGVV
3760 3770 3780 3790 3800
VMDSALEALS GSLLVGKVPE IWAKRSYPSL KPLGSYITDF LARLNFLQDW
3810 3820 3830 3840 3850
YNSGKPCVFW LSGFFFTQAF LTGAMQNYAR KYTTPIDLLG YEFEVIPSDT
3860 3870 3880 3890 3900
SDTSPEDGVY IHGLYLDGAR WDRESGLLAE QYPKLLFDLM PIIWIKPTQK
3910 3920 3930 3940 3950
SRIIKSDAYV CPLYKTSERK GTLSTTGHST NFVIAMLLKT DQPTRHWIKR
3960
GVALLCQLDD
Length:3,960
Mass (Da):454,326
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5700650CAFFFFADA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZR08DYH12_HUMAN
Dynein heavy chain 12, axonemal
DNAH12 DHC3, DLP12, DNAH12L, DNAH7L, DNAHC3
3,092Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5N3H7C5N3_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QTM1J3QTM1_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
784Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5S4H7C5S4_HUMAN
Dynein heavy chain 12, axonemal
DNAH12
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC092418 Genomic DNA No translation available.
AC093928 Genomic DNA No translation available.
AC121250 Genomic DNA No translation available.
AC231288 Genomic DNA No translation available.
AC232304 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_011531768.1, XM_011533466.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000495027; ENSP00000418137; ENSG00000174844

UCSC genome browser

More...
UCSCi
uc032rop.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092418 Genomic DNA No translation available.
AC093928 Genomic DNA No translation available.
AC121250 Genomic DNA No translation available.
AC231288 Genomic DNA No translation available.
AC232304 Genomic DNA No translation available.
RefSeqiXP_011531768.1, XM_011533466.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiE9PG32
PeptideAtlasiE9PG32
PRIDEiE9PG32
ProteomicsDBi20233

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48520 65 antibodies

Genome annotation databases

EnsembliENST00000495027; ENSP00000418137; ENSG00000174844
UCSCiuc032rop.2 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000174844.14
HGNCiHGNC:2943 DNAH12
OpenTargetsiENSG00000174844

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000154280
HOGENOMiCLU_000038_0_1_1
OMAiICDYNAS
OrthoDBi2079at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DNAH12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
201625

Gene expression databases

BgeeiENSG00000174844 Expressed in bronchial epithelial cell and 100 other tissues
ExpressionAtlasiE9PG32 baseline and differential

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 3 hits
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PG32_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PG32
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 29, 2014
Last modified: April 22, 2020
This is version 65 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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