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Entry version 69 (11 Dec 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

C-Jun-amino-terminal kinase-interacting protein 3

Gene

MAPK8IP3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
C-Jun-amino-terminal kinase-interacting protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPK8IP3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138834.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6884 MAPK8IP3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000138834

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9PFH7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PFH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PFH7

PeptideAtlas

More...
PeptideAtlasi
E9PFH7

PRoteomics IDEntifications database

More...
PRIDEi
E9PFH7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20106

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138834 Expressed in 219 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PFH7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PFH7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 100RH1InterPro annotationAdd BLAST89
Domaini514 – 588RH2InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni182 – 212DisorderedSequence analysisAdd BLAST31
Regioni243 – 318DisorderedSequence analysisAdd BLAST76
Regioni713 – 760DisorderedSequence analysisAdd BLAST48
Regioni873 – 963DisorderedSequence analysisAdd BLAST91
Regioni1290 – 1309DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili66 – 167Sequence analysisAdd BLAST102
Coiled coili442 – 490Sequence analysisAdd BLAST49
Coiled coili522 – 542Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi243 – 289PolarSequence analysisAdd BLAST47
Compositional biasi303 – 318PolyampholyteSequence analysisAdd BLAST16
Compositional biasi730 – 760PolyampholyteSequence analysisAdd BLAST31
Compositional biasi876 – 891PolarSequence analysisAdd BLAST16
Compositional biasi933 – 949PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2077 Eukaryota
ENOG410XQ19 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153496

Database of Orthologous Groups

More...
OrthoDBi
324912at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13886 PTHR13886, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PFH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE
60 70 80 90 100
VVKELMPLVV NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL
110 120 130 140 150
RRQAEEKFIE FEDALEQEKK ELQIQVEHYE FQTRQLELKA KNYADQISRL
160 170 180 190 200
EERESEMKKE YNALHQRHTE MIQTYVEHIE RSKMQQVGGN SQTESSLPGR
210 220 230 240 250
RKERPTSLNV FPLADGTVRA QIGGKLVPAG DHWHLSDLGQ LQSSSSYQCP
260 270 280 290 300
QDEMSESGQS SAAATPSTTG TKSNTPTSSV PSAAVTPLNE SLQPLGDYGV
310 320 330 340 350
GSKNSKRARE KRDSRNMEVQ VTQEMRNVSI GMGSSDEWSD VQDIIDSTPE
360 370 380 390 400
LDMCPETRLD RTGSSPTQGI VNKAFGINTD SLYHELSTAG SEVIGDVDEG
410 420 430 440 450
ADLLGEFSGM GKEVGNLLLE NSQLLETKNA LNVVKNDLIA KVDQLSGEQE
460 470 480 490 500
VLRGELEAAK QAKVKLENRI KELEEELKRV KSEAIIARRE PKEEAEDVSS
510 520 530 540 550
YLCTESDKIP MAQRRRFTRV EMARVLMERN QYKERLMELQ EAVRWTEMIR
560 570 580 590 600
ASREHPSVQE KKKSTIWQFF SRLFSSSSSP PPAKRPYPSV NIHYKSPTTA
610 620 630 640 650
GFSQRRNHAM CPISAGSRPL EFFPDDDCTS SARREQKREQ YRQVREHVRN
660 670 680 690 700
DDGRLQACGW SLPAKYKQLS PNGGQEDTRM KNVPVPVYCR PLVEKDPTMK
710 720 730 740 750
LWCAAGVNLS GWRPNEDDAG NGVKPAPGRD PLTCDREGDG EPKSAHTSPE
760 770 780 790 800
KKKAKELPEM DATSSRVWIL TSTLTTSKVV IIDANQPGTV VDQFTVCNAH
810 820 830 840 850
VLCISSIPAA SDSDYPPGEM FLDSDVNPED PGADGVLAGI TLVGCATRCN
860 870 880 890 900
VPRSNCSSRG DTPVLDKGQG EVATIANGKV NPSQSTEEAT EATEVPDPGP
910 920 930 940 950
SEPETATLRP GPLTEHVFTD PAPTPSSGPQ PGSENGPEPD SSSTRPEPEP
960 970 980 990 1000
SGDPTGAGSS AAPTMWLGAQ NGWLYVHSAV ANWKKCLHSI KLKDSVLSLV
1010 1020 1030 1040 1050
HVKGRVLVAL ADGTLAIFHR GEDGQWDLSN YHLMDLGHPH HSIRCMAVVY
1060 1070 1080 1090 1100
DRVWCGYKNK VHVIQPKTMQ IEKSFDAHPR RESQVRQLAW IGDGVWVSIR
1110 1120 1130 1140 1150
LDSTLRLYHA HTHQHLQDVD IEPYVSKMLG TGKLGFSFVR ITALLVAGSR
1160 1170 1180 1190 1200
LWVGTGNGVV ISIPLTETVV LHRGQLLGLR ANKTSPTSGE GARPGGIIHV
1210 1220 1230 1240 1250
YGDDSSDRAA SSFIPYCSMA QAQLCFHGHR DAVKFFVSVP GNVLATLNGS
1260 1270 1280 1290 1300
VLDSPAEGPG PAAPASEVEG QKLRNVLVLS GGEGYIDFRI GDGEDDETEE
1310 1320 1330
GAGDMSQVKP VLSKAERSHI IVWQVSYTPE
Length:1,330
Mass (Da):146,677
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EEF88EF17E0F104
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPT6JIP3_HUMAN
C-Jun-amino-terminal kinase-interac...
MAPK8IP3 JIP3, KIAA1066
1,336Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYG2A0A087WYG2_HUMAN
C-Jun-amino-terminal kinase-interac...
MAPK8IP3
1,337Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN91H3BN91_HUMAN
C-Jun-amino-terminal kinase-interac...
MAPK8IP3
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC012180 Genomic DNA No translation available.
AL031710 Genomic DNA No translation available.
AL031717 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001035529.1, NM_001040439.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356010; ENSP00000348290; ENSG00000138834

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23162

UCSC genome browser

More...
UCSCi
uc059ozt.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012180 Genomic DNA No translation available.
AL031710 Genomic DNA No translation available.
AL031717 Genomic DNA No translation available.
RefSeqiNP_001035529.1, NM_001040439.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiE9PFH7
jPOSTiE9PFH7
MaxQBiE9PFH7
PeptideAtlasiE9PFH7
PRIDEiE9PFH7
ProteomicsDBi20106

Genome annotation databases

EnsembliENST00000356010; ENSP00000348290; ENSG00000138834
GeneIDi23162
UCSCiuc059ozt.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23162
EuPathDBiHostDB:ENSG00000138834.12
HGNCiHGNC:6884 MAPK8IP3
OpenTargetsiENSG00000138834

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2077 Eukaryota
ENOG410XQ19 LUCA
GeneTreeiENSGT00940000153496
OrthoDBi324912at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAPK8IP3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23162

Gene expression databases

BgeeiENSG00000138834 Expressed in 219 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiE9PFH7 baseline and differential
GenevisibleiE9PFH7 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13886 PTHR13886, 1 hit
PfamiView protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PFH7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PFH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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