UniProtKB - E9PFF5 (E9PFF5_HUMAN)
Protein
Submitted name:
Fragile X mental retardation syndrome-related protein 1
Gene
FXR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- mRNA binding Source: InterPro
GO - Biological processi
- regulation of translation Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Fragile X mental retardation syndrome-related protein 1Imported |
Gene namesi | Name:FXR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4023, FXR1 |
VEuPathDBi | HostDB:ENSG00000114416.17 |
PTM / Processingi
Proteomic databases
MaxQBi | E9PFF5 |
PeptideAtlasi | E9PFF5 |
PRIDEi | E9PFF5 |
ProteomicsDBi | 20090 |
Expressioni
Gene expression databases
Bgeei | ENSG00000114416, Expressed in testis and 245 other tissues |
ExpressionAtlasi | E9PFF5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 66 | Agenet-likeInterPro annotationAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 332 – 490 | DisorderedSequence analysisAdd BLAST | 159 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 360 – 395 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 418 – 440 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the FMR1 family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000183189 |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits |
InterProi | View protein in InterPro IPR008395, Agenet-like_dom IPR040148, FMR1 IPR040472, FMRP_KH0 IPR022034, FXMRP1_C_core IPR032172, FXR_C1 IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
PANTHERi | PTHR10603, PTHR10603, 2 hits |
Pfami | View protein in Pfam PF05641, Agenet, 1 hit PF12235, FXMRP1_C_core, 2 hits PF16096, FXR_C1, 1 hit PF00013, KH_1, 2 hits PF17904, KH_9, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 2 hits |
SUPFAMi | SSF54791, SSF54791, 2 hits |
PROSITEi | View protein in PROSITE PS51641, AGENET_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
E9PFF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELTVEVRG SNGAFYKVYS RANDQEPCGW WLAKVRMMKG EFYVIEYAAC
60 70 80 90 100
DATYNEIVTF ERLRPVNQNK TVKKNTFFKC TVDVPEDLRE ACANENAHKD
110 120 130 140 150
FKKAVGACRI FYHPETTQLM ILSASEATVK RVNILSDMHL RSIRTKLMLM
160 170 180 190 200
SRNEEATKHL ECTKQLAAAF HEEFVVREDL MGLAIGTHGS NIQQARKVPG
210 220 230 240 250
VTAIELDEDT GTFRIYGESA DAVKKARGFL EFVEDFIQVP RNLVGKVIGK
260 270 280 290 300
NGKVIQEIVD KSGVVRVRIE GDNENKLPRE DGMVPFVFVG TKESIGNVQV
310 320 330 340 350
LLEYHIAYLK EVEQLRMERL QIDEQLRQIG SRSYSGRGRG RRGPNYTSGY
360 370 380 390 400
GTNSELSNPS ETESERKDEL SDWSLAGEDD RDSRHQRDSR RRPGGRGRSV
410 420 430 440 450
SGGRGRGGPR GGKSSISSVL KDPDSNPYSL LDNTESDQTA DTDASESHHS
460 470 480 490
TNRRRRSRRR RTDEDAVLMD GMTESDTASV NENGLGKRCD
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP51114 | FXR1_HUMAN | Fragile X mental retardation syndro... | FXR1 | 621 | Annotation score: | ||
B4DXZ6 | B4DXZ6_HUMAN | Fragile X mental retardation syndro... | FXR1 | 608 | Annotation score: | ||
E7EU85 | E7EU85_HUMAN | Fragile X mental retardation syndro... | FXR1 | 454 | Annotation score: | ||
H7C4S4 | H7C4S4_HUMAN | Fragile X mental retardation syndro... | FXR1 | 246 | Annotation score: | ||
C9JAJ4 | C9JAJ4_HUMAN | Fragile X mental retardation syndro... | FXR1 | 151 | Annotation score: | ||
C9JY20 | C9JY20_HUMAN | Fragile X mental retardation syndro... | FXR1 | 123 | Annotation score: | ||
C9IZ22 | C9IZ22_HUMAN | Fragile X mental retardation syndro... | FXR1 | 94 | Annotation score: | ||
C9J5B4 | C9J5B4_HUMAN | Fragile X mental retardation syndro... | FXR1 | 75 | Annotation score: | ||
C9JZE0 | C9JZE0_HUMAN | Fragile X mental retardation syndro... | FXR1 | 119 | Annotation score: | ||
C9JYQ6 | C9JYQ6_HUMAN | Fragile X mental retardation syndro... | FXR1 | 19 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008009 Genomic DNA No translation available. AC068638 Genomic DNA No translation available. AC108734 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000491062; ENSP00000420643; ENSG00000114416 |
UCSCi | uc011bqk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008009 Genomic DNA No translation available. AC068638 Genomic DNA No translation available. AC108734 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E9PFF5 |
PeptideAtlasi | E9PFF5 |
PRIDEi | E9PFF5 |
ProteomicsDBi | 20090 |
Protocols and materials databases
Antibodypediai | 18845, 331 antibodies |
Genome annotation databases
Ensembli | ENST00000491062; ENSP00000420643; ENSG00000114416 |
UCSCi | uc011bqk.3, human |
Organism-specific databases
HGNCi | HGNC:4023, FXR1 |
OpenTargetsi | ENSG00000114416 |
VEuPathDBi | HostDB:ENSG00000114416.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183189 |
Miscellaneous databases
ChiTaRSi | FXR1, human |
Gene expression databases
Bgeei | ENSG00000114416, Expressed in testis and 245 other tissues |
ExpressionAtlasi | E9PFF5, baseline and differential |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits |
InterProi | View protein in InterPro IPR008395, Agenet-like_dom IPR040148, FMR1 IPR040472, FMRP_KH0 IPR022034, FXMRP1_C_core IPR032172, FXR_C1 IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
PANTHERi | PTHR10603, PTHR10603, 2 hits |
Pfami | View protein in Pfam PF05641, Agenet, 1 hit PF12235, FXMRP1_C_core, 2 hits PF16096, FXR_C1, 1 hit PF00013, KH_1, 2 hits PF17904, KH_9, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 2 hits |
SUPFAMi | SSF54791, SSF54791, 2 hits |
PROSITEi | View protein in PROSITE PS51641, AGENET_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PFF5_HUMAN | |
Accessioni | E9PFF5Primary (citable) accession number: E9PFF5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |