UniProtKB - E9PFD7 (E9PFD7_HUMAN)
Protein
Receptor protein-tyrosine kinase
Gene
EGFR
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 700 | ATPUniRule annotation | 1 | |
Active sitei | 792 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 673 – 681 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
GO - Biological processi
- transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EGFRImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3236, EGFR |
VEuPathDBi | HostDB:ENSG00000146648.15 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell junction Source: HPA
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 601 – 622 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5003244049 | 25 – 1165 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 1141 |
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | E9PFD7 |
PRIDEi | E9PFD7 |
ProteomicsDBi | 20079 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146648, Expressed in placenta and 242 other tissues |
ExpressionAtlasi | E9PFD7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 667 – 934 | Protein kinaseInterPro annotationAdd BLAST | 268 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1052 – 1092 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1054 – 1069 | PolarSequence analysisAdd BLAST | 16 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155450 |
HOGENOMi | CLU_003384_5_1_1 |
OMAi | PECKGCT |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 3 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF01030, Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619, TyrPK_EGF-R, 3 hits |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00261, FU, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9PFD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS
60 70 80 90 100
LQRMFNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
110 120 130 140 150
LENLQIIRGN MYYENSYALA VLSNYDANKT GLKELPMRNL QGQKCDPSCP
160 170 180 190 200
NGSCWGAGEE NCQKLTKIIC AQQCSGRCRG KSPSDCCHNQ CAAGCTGPRE
210 220 230 240 250
SDCLVCRKFR DEATCKDTCP PLMLYNPTTY QMDVNPEGKY SFGATCVKKC
260 270 280 290 300
PRNYVVTDHG SCVRACGADS YEMEEDGVRK CKKCEGPCRK VCNGIGIGEF
310 320 330 340 350
KDSLSINATN IKHFKNCTSI SGDLHILPVA FRGDSFTHTP PLDPQELDIL
360 370 380 390 400
KTVKEITGFL LIQAWPENRT DLHAFENLEI IRGRTKQHGQ FSLAVVSLNI
410 420 430 440 450
TSLGLRSLKE ISDGDVIISG NKNLCYANTI NWKKLFGTSG QKTKIISNRG
460 470 480 490 500
ENSCKATGQV CHALCSPEGC WGPEPRDCVS CRNVSRGREC VDKCNLLEGE
510 520 530 540 550
PREFVENSEC IQCHPECLPQ AMNITCTGRG PDNCIQCAHY IDGPHCVKTC
560 570 580 590 600
PAGVMGENNT LVWKYADAGH VCHLCHPNCT YGCTGPGLEG CPTNGPKIPS
610 620 630 640 650
IATGMVGALL LLLVVALGIG LFMRRRHIVR KRTLRRLLQE RELVEPLTPS
660 670 680 690 700
GEAPNQALLR ILKETEFKKI KVLGSGAFGT VYKGLWIPEG EKVKIPVAIK
710 720 730 740 750
ELREATSPKA NKEILDEAYV MASVDNPHVC RLLGICLTST VQLITQLMPF
760 770 780 790 800
GCLLDYVREH KDNIGSQYLL NWCVQIAKGM NYLEDRRLVH RDLAARNVLV
810 820 830 840 850
KTPQHVKITD FGLAKLLGAE EKEYHAEGGK VPIKWMALES ILHRIYTHQS
860 870 880 890 900
DVWSYGVTVW ELMTFGSKPY DGIPASEISS ILEKGERLPQ PPICTIDVYM
910 920 930 940 950
IMVKCWMIDA DSRPKFRELI IEFSKMARDP QRYLVIQGDE RMHLPSPTDS
960 970 980 990 1000
NFYRALMDEE DMDDVVDADE YLIPQQGFFS SPSTSRTPLL SSLSATSNNS
1010 1020 1030 1040 1050
TVACIDRNGL QSCPIKEDSF LQRYSSDPTG ALTEDSIDDT FLPVPEYINQ
1060 1070 1080 1090 1100
SVPKRPAGSV QNPVYHNQPL NPAPSRDPHY QDPHSTAVGN PEYLNTVQPT
1110 1120 1130 1140 1150
CVNSTFDSPA HWAQKGSHQI SLDNPDYQQD FFPKEAKPNG IFKGSTAENA
1160
EYLRVAPQSS EFIGA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP00533 | EGFR_HUMAN | Epidermal growth factor receptor | EGFR ERBB, ERBB1, HER1 | 1,210 | Annotation score: | ||
Q504U8 | Q504U8_HUMAN | Receptor protein-tyrosine kinase | EGFR | 1,091 | Annotation score: | ||
C9JYS6 | C9JYS6_HUMAN | Epidermal growth factor receptor | EGFR | 128 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006977 Genomic DNA No translation available. AC073324 Genomic DNA No translation available. KF458469 Genomic DNA No translation available. |
RefSeqi | NP_001333828.1, NM_001346899.1 |
Genome annotation databases
Ensembli | ENST00000454757; ENSP00000395243; ENSG00000146648 |
GeneIDi | 1956 |
UCSCi | uc022adn.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006977 Genomic DNA No translation available. AC073324 Genomic DNA No translation available. KF458469 Genomic DNA No translation available. |
RefSeqi | NP_001333828.1, NM_001346899.1 |
3D structure databases
SMRi | E9PFD7 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | E9PFD7 |
PRIDEi | E9PFD7 |
ProteomicsDBi | 20079 |
Protocols and materials databases
Antibodypediai | 718, 9511 antibodies |
DNASUi | 1956 |
Genome annotation databases
Ensembli | ENST00000454757; ENSP00000395243; ENSG00000146648 |
GeneIDi | 1956 |
UCSCi | uc022adn.2, human |
Organism-specific databases
CTDi | 1956 |
HGNCi | HGNC:3236, EGFR |
OpenTargetsi | ENSG00000146648 |
VEuPathDBi | HostDB:ENSG00000146648.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155450 |
HOGENOMi | CLU_003384_5_1_1 |
OMAi | PECKGCT |
Miscellaneous databases
BioGRID-ORCSi | 1956, 134 hits in 1026 CRISPR screens |
ChiTaRSi | EGFR, human |
GenomeRNAii | 1956 |
Gene expression databases
Bgeei | ENSG00000146648, Expressed in placenta and 242 other tissues |
ExpressionAtlasi | E9PFD7, baseline and differential |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 3 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF01030, Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619, TyrPK_EGF-R, 3 hits |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00261, FU, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PFD7_HUMAN | |
Accessioni | E9PFD7Primary (citable) accession number: E9PFD7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | April 7, 2021 | |
This is version 88 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |