UniProtKB - E9PF82 (E9PF82_HUMAN)
Protein
Calcium/calmodulin-dependent protein kinase
Gene
CAMK2D
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: UniProtKB-EC
- protein serine kinase activity Source: RHEA
- protein threonine kinase activity Source: RHEA
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | E9PF82 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium/calmodulin-dependent protein kinaseARBA annotation (EC:2.7.11.17ARBA annotation) |
Gene namesi | Name:CAMK2DImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1462, CAMK2D |
VEuPathDBi | HostDB:ENSG00000145349.16 |
PTM / Processingi
Proteomic databases
EPDi | E9PF82 |
MaxQBi | E9PF82 |
PeptideAtlasi | E9PF82 |
PRIDEi | E9PF82 |
ProteomicsDBi | 20049 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145349, Expressed in middle temporal gyrus and 212 other tissues |
ExpressionAtlasi | E9PF82, baseline and differential |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | E9PF82, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 272 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 337 – 375 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 337 – 367 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155150 |
HOGENOMi | CLU_000288_71_3_1 |
OMAi | EDTACIA |
OrthoDBi | 330091at2759 |
PhylomeDBi | E9PF82 |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9PF82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKSKG
160 170 180 190 200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN
260 270 280 290 300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALEP
360 370 380 390 400
QTTVIHNPDG NKESTESSNT TIEDEDVKAR KQEIIKVTEQ LIEAINNGDF
410 420 430 440 450
EAYTKICDPG LTAFEPEALG NLVEGMDFHR FYFENALSKS NKPIHTIILN
460 470 480 490 500
PHVHLVGDDA ACIAYIRLTQ YMDGSGMPKT MQSEETRVWH RRDGKWQNVH
510 520 530
FHRSGSPTVP IKPPCIPNGK ENFSGGTSLW QNI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13557 | KCC2D_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D CAMKD | 499 | Annotation score: | ||
E9PBG7 | E9PBG7_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 512 | Annotation score: | ||
D6R938 | D6R938_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D hCG_22679 | 498 | Annotation score: | ||
H0Y9C2 | H0Y9C2_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 194 | Annotation score: | ||
H0Y9J2 | H0Y9J2_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 182 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004056 Genomic DNA No translation available. AC004168 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC107386 Genomic DNA No translation available. |
RefSeqi | NP_001308500.1, NM_001321571.1 |
Genome annotation databases
Ensembli | ENST00000511664; ENSP00000425824; ENSG00000145349 |
GeneIDi | 817 |
UCSCi | uc003ibo.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004056 Genomic DNA No translation available. AC004168 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC107386 Genomic DNA No translation available. |
RefSeqi | NP_001308500.1, NM_001321571.1 |
3D structure databases
SMRi | E9PF82 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | E9PF82, 1 interactor |
Proteomic databases
EPDi | E9PF82 |
MaxQBi | E9PF82 |
PeptideAtlasi | E9PF82 |
PRIDEi | E9PF82 |
ProteomicsDBi | 20049 |
Protocols and materials databases
Antibodypediai | 15593, 332 antibodies |
DNASUi | 817 |
Genome annotation databases
Ensembli | ENST00000511664; ENSP00000425824; ENSG00000145349 |
GeneIDi | 817 |
UCSCi | uc003ibo.5, human |
Organism-specific databases
CTDi | 817 |
HGNCi | HGNC:1462, CAMK2D |
OpenTargetsi | ENSG00000145349 |
VEuPathDBi | HostDB:ENSG00000145349.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155150 |
HOGENOMi | CLU_000288_71_3_1 |
OMAi | EDTACIA |
OrthoDBi | 330091at2759 |
PhylomeDBi | E9PF82 |
Enzyme and pathway databases
SignaLinki | E9PF82 |
Miscellaneous databases
BioGRID-ORCSi | 817, 8 hits in 1017 CRISPR screens |
ChiTaRSi | CAMK2D, human |
GenomeRNAii | 817 |
Gene expression databases
Bgeei | ENSG00000145349, Expressed in middle temporal gyrus and 212 other tissues |
ExpressionAtlasi | E9PF82, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PF82_HUMAN | |
Accessioni | E9PF82Primary (citable) accession number: E9PF82 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |