Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Gene

HADH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialImported
Gene namesi
Name:HADHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138796.15
HGNCiHGNC:4799 HADH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138796

PTM / Processingi

Proteomic databases

EPDiE9PF18
PRIDEiE9PF18

Expressioni

Gene expression databases

BgeeiENSG00000138796 Expressed in 233 organ(s), highest expression level in parietal pleura
ExpressionAtlasiE9PF18 baseline and differential

Structurei

3D structure databases

SMRiE9PF18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 2733HCDH_NInterPro annotationAdd BLAST186
Domaini312 – 3893HCDHInterPro annotationAdd BLAST78

Phylogenomic databases

GeneTreeiENSGT00880000137923
OMAiMAHPMGP

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

E9PF18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAGLEAPP PPCGVTGTPG ARGLQGRVGP RPQSLAFRGC PPRASSLPGS
60 70 80 90 100
PRCRRRCHTM AFVTRQFMRS VSSSSTASAS AKKIIVKHVT VIGGGLMGAG
110 120 130 140 150
IAQVAAATGH TVVLVDQTED ILAKSKKGIE ESLRKVAKKK FAENLKAGDE
160 170 180 190 200
FVEKTLSTIA TSTDAASVVH STDLVVEAIV ENLKVKNELF KRLDKFAAEH
210 220 230 240 250
TIFASNTSSL QITSIANATT RQDRFAGLHF FNPVPVMKLV EVIKTPMTSQ
260 270 280 290 300
KTFESLVDFS KALGKHPVSC KDTPGFIVNR LLVPYLMEAI RLYERDFQTC
310 320 330 340 350
GDSNSGLGFS LKGDASKEDI DTAMKLGAGY PMGPFELLDY VGLDTTKFIV
360 370 380 390
DGWHEMDAEN PLHQPSPSLN KLVAENKFGK KTGEGFYKYK
Length:390
Mass (Da):42,123
Last modified:June 7, 2017 - v2
Checksum:iA07F1CAC27704B7C
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q16836HCDH_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH HAD, HADHSC, SCHAD
314Annotation score:
A0A0A0MSE2A0A0A0MSE2_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
317Annotation score:
A0A0D9SFP2A0A0D9SFP2_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
318Annotation score:
A0A1W2PQV5A0A1W2PQV5_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
245Annotation score:
A0A1W2PNM1A0A1W2PNM1_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
267Annotation score:
A0A1W2PQ78A0A1W2PQ78_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
176Annotation score:
A0A1W2PP40A0A1W2PP40_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
145Annotation score:
A0A1W2PQC2A0A1W2PQC2_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
165Annotation score:
A0A1W2PRT2A0A1W2PRT2_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
183Annotation score:
A0A1W2PQ55A0A1W2PQ55_HUMAN
Hydroxyacyl-coenzyme A dehydrogenas...
HADH
100Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114733 Genomic DNA No translation available.
AC118062 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000505878; ENSP00000425952; ENSG00000138796
UCSCiuc003hyr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114733 Genomic DNA No translation available.
AC118062 Genomic DNA No translation available.

3D structure databases

SMRiE9PF18
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiE9PF18
PRIDEiE9PF18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000505878; ENSP00000425952; ENSG00000138796
UCSCiuc003hyr.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000138796.15
HGNCiHGNC:4799 HADH
OpenTargetsiENSG00000138796
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00880000137923
OMAiMAHPMGP

Miscellaneous databases

ChiTaRSiHADH human
GenomeRNAii3033

Gene expression databases

BgeeiENSG00000138796 Expressed in 233 organ(s), highest expression level in parietal pleura
ExpressionAtlasiE9PF18 baseline and differential

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PF18_HUMAN
AccessioniPrimary (citable) accession number: E9PF18
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 7, 2017
Last modified: September 12, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again