UniProtKB - E9PF18 (E9PF18_HUMAN)

BLAST

>tr|E9PF18|E9PF18_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=2
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTM
AFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTED
ILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIV
ENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLV
EVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERDFQTC
GDSNSGLGFSLKGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAEN
PLHQPSPSLNKLVAENKFGKKTGEGFYKYK

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History
Entry version 65 (12 Sep 2018)
Sequence version 2 (07 Jun 2017)
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Protein

Submitted name:

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Gene

HADH

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialImported
Gene namesⁱ	Name:HADHImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138796.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4799 HADH

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000138796

OpenTargetsⁱ

ENSG00000138796

PTM / Processingⁱ

Proteomic databases

EPDⁱ	E9PF18
PRIDEⁱ	E9PF18

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000138796 Expressed in 233 organ(s), highest expression level in parietal pleura
ExpressionAtlasⁱ	E9PF18 baseline and differential

Structureⁱ

3D structure databases

SMRⁱ	E9PF18
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	88 – 273	3HCDH_NInterPro annotationAdd BLAST		186
Domainⁱ	312 – 389	3HCDHInterPro annotationAdd BLAST		78

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137923
OMAⁱ	MAHPMGP

Family and domain databases

Gene3Dⁱ	1.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR006176 3-OHacyl-CoA_DH_NAD-bd IPR006108 3HC_DH_C IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00725 3HCDH, 1 hit PF02737 3HCDH_N, 1 hit
SUPFAMⁱ	SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show all Align All

E9PF18-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGRAGLEAPP PPCGVTGTPG ARGLQGRVGP RPQSLAFRGC PPRASSLPGS 
        60         70         80         90        100
PRCRRRCHTM AFVTRQFMRS VSSSSTASAS AKKIIVKHVT VIGGGLMGAG 
       110        120        130        140        150
IAQVAAATGH TVVLVDQTED ILAKSKKGIE ESLRKVAKKK FAENLKAGDE 
       160        170        180        190        200
FVEKTLSTIA TSTDAASVVH STDLVVEAIV ENLKVKNELF KRLDKFAAEH 
       210        220        230        240        250
TIFASNTSSL QITSIANATT RQDRFAGLHF FNPVPVMKLV EVIKTPMTSQ 
       260        270        280        290        300
KTFESLVDFS KALGKHPVSC KDTPGFIVNR LLVPYLMEAI RLYERDFQTC 
       310        320        330        340        350
GDSNSGLGFS LKGDASKEDI DTAMKLGAGY PMGPFELLDY VGLDTTKFIV 
       360        370        380        390
DGWHEMDAEN PLHQPSPSLN KLVAENKFGK KTGEGFYKYK

Length:390

Mass (Da):42,123

Last modified:June 7, 2017 - v2

Checksum:ⁱA07F1CAC27704B7C

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	Q16836	HCDH_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, HCDH, EC 1.1.1.35 (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)	HADH HAD, HADHSC, SCHAD	314	Annotation score:
	A0A0A0MSE2	A0A0A0MSE2_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	317	Annotation score:
	A0A0D9SFP2	A0A0D9SFP2_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	318	Annotation score:
	A0A1W2PQV5	A0A1W2PQV5_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	245	Annotation score:
	A0A1W2PNM1	A0A1W2PNM1_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	267	Annotation score:
	A0A1W2PQ78	A0A1W2PQ78_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	176	Annotation score:
	A0A1W2PP40	A0A1W2PP40_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	145	Annotation score:
	A0A1W2PQC2	A0A1W2PQC2_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	165	Annotation score:
	A0A1W2PRT2	A0A1W2PRT2_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	183	Annotation score:
	A0A1W2PQ55	A0A1W2PQ55_HUMAN	Hydroxyacyl-coenzyme A dehydrogenas... Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	100	Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC114733 Genomic DNA No translation available. AC118062 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC114733 Genomic DNA No translation available.
AC118062 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000505878; ENSP00000425952; ENSG00000138796
UCSC genome browser More...UCSCⁱ	uc003hyr.4 human

Protein	Similar proteins		Species	Score	Length	Source
E9PF18	Isoform 2 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial		HUMAN		390	UniRef90_Q16836-2
Uncharacterized protein		PANPA		452
Hydroxyacyl-CoA dehydrogenase		PANTR		314
Uncharacterized protein		NOMLE		390
Hydroxyacyl-CoA dehydrogenase		GORGO		390
+14

Protein	Similar proteins		Species	Score	Length	Source
E9PF18	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	)	HUMAN		314	UniRef50_Q16836
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	)	PIG		314
Uncharacterized protein		MACFA		390
Uncharacterized protein		PAPAN		374
Uncharacterized protein		MACMU		372
+122

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC114733 Genomic DNA No translation available. AC118062 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC114733 Genomic DNA No translation available.
AC118062 Genomic DNA No translation available.

3D structure databases

SMRⁱ	E9PF18
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	E9PF18
PRIDEⁱ	E9PF18

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000505878; ENSP00000425952; ENSG00000138796
UCSCⁱ	uc003hyr.4 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138796.15
HGNCⁱ	HGNC:4799 HADH
OpenTargetsⁱ	ENSG00000138796
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00880000137923
OMAⁱ	MAHPMGP

Miscellaneous databases

ChiTaRSⁱ	HADH human
GenomeRNAiⁱ	3033

Gene expression databases

Bgeeⁱ	ENSG00000138796 Expressed in 233 organ(s), highest expression level in parietal pleura
ExpressionAtlasⁱ	E9PF18 baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR006176 3-OHacyl-CoA_DH_NAD-bd IPR006108 3HC_DH_C IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR036291 NAD(P)-bd_dom_sf
Pfamⁱ	View protein in Pfam PF00725 3HCDH, 1 hit PF02737 3HCDH_N, 1 hit
SUPFAMⁱ	SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9PF18_HUMAN
Accessionⁱ	E9PF18Primary (citable) accession number: E9PF18
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	June 7, 2017
	Last modified:	September 12, 2018
	This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - E9PF18 (E9PF18_HUMAN)

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Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

HADH

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ