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UniProtKB - E9PF18 (E9PF18_HUMAN)
Protein
Submitted name:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Gene
HADH
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- NAD+ binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- fatty acid metabolic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialImported |
Gene namesi | Name:HADHImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4799, HADH |
VEuPathDBi | HostDB:ENSG00000138796 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138796, Expressed in parietal pleura and 246 other tissues |
ExpressionAtlasi | E9PF18, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 88 – 273 | 3HCDH_NInterPro annotationAdd BLAST | 186 | |
Domaini | 312 – 389 | 3HCDHInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 51 | DisorderedSequence analysisAdd BLAST | 51 |
Phylogenomic databases
GeneTreei | ENSGT00940000159984 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
E9PF18-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRAGLEAPP PPCGVTGTPG ARGLQGRVGP RPQSLAFRGC PPRASSLPGS
60 70 80 90 100
PRCRRRCHTM AFVTRQFMRS VSSSSTASAS AKKIIVKHVT VIGGGLMGAG
110 120 130 140 150
IAQVAAATGH TVVLVDQTED ILAKSKKGIE ESLRKVAKKK FAENLKAGDE
160 170 180 190 200
FVEKTLSTIA TSTDAASVVH STDLVVEAIV ENLKVKNELF KRLDKFAAEH
210 220 230 240 250
TIFASNTSSL QITSIANATT RQDRFAGLHF FNPVPVMKLV EVIKTPMTSQ
260 270 280 290 300
KTFESLVDFS KALGKHPVSC KDTPGFIVNR LLVPYLMEAI RLYERDFQTC
310 320 330 340 350
GDSNSGLGFS LKGDASKEDI DTAMKLGAGY PMGPFELLDY VGLDTTKFIV
360 370 380 390
DGWHEMDAEN PLHQPSPSLN KLVAENKFGK KTGEGFYKYK
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ16836 | HCDH_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH HAD, HAD1, HADHSC, SCHAD | 314 | Annotation score: | ||
A0A0A0MSE2 | A0A0A0MSE2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 317 | Annotation score: | ||
A0A0D9SFP2 | A0A0D9SFP2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 318 | Annotation score: | ||
A0A1W2PNM1 | A0A1W2PNM1_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 267 | Annotation score: | ||
A0A1W2PQV5 | A0A1W2PQV5_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 245 | Annotation score: | ||
A0A1W2PQ78 | A0A1W2PQ78_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 176 | Annotation score: | ||
A0A1W2PP40 | A0A1W2PP40_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 145 | Annotation score: | ||
A0A1W2PQC2 | A0A1W2PQC2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 165 | Annotation score: | ||
A0A1W2PRT2 | A0A1W2PRT2_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 183 | Annotation score: | ||
A0A1W2PQ55 | A0A1W2PQ55_HUMAN | Hydroxyacyl-coenzyme A dehydrogenas... | HADH | 100 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114733 Genomic DNA No translation available. AC118062 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000505878; ENSP00000425952; ENSG00000138796 |
UCSCi | uc003hyr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114733 Genomic DNA No translation available. AC118062 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PF18 |
ModBasei | Search... |
Proteomic databases
EPDi | E9PF18 |
PeptideAtlasi | E9PF18 |
PRIDEi | E9PF18 |
ProteomicsDBi | 20006 |
Protocols and materials databases
Antibodypediai | 26260, 554 antibodies from 34 providers |
Genome annotation databases
Ensembli | ENST00000505878; ENSP00000425952; ENSG00000138796 |
UCSCi | uc003hyr.4, human |
Organism-specific databases
HGNCi | HGNC:4799, HADH |
OpenTargetsi | ENSG00000138796 |
VEuPathDBi | HostDB:ENSG00000138796 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159984 |
Miscellaneous databases
ChiTaRSi | HADH, human |
Gene expression databases
Bgeei | ENSG00000138796, Expressed in parietal pleura and 246 other tissues |
ExpressionAtlasi | E9PF18, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PF18_HUMAN | |
Accessioni | E9PF18Primary (citable) accession number: E9PF18 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | June 7, 2017 | |
Last modified: | January 19, 2022 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |