ID E9PDY4_HUMAN Unreviewed; 2489 AA. AC E9PDY4; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 27-MAR-2024, entry version 88. DE SubName: Full=Complement C3b/C4b receptor 1 (Knops blood group) {ECO:0000313|Ensembl:ENSP00000356016.4}; GN Name=CR1 {ECO:0000313|Ensembl:ENSP00000356016.4}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356016.4, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000356016.4, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000356016.4} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL137789; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL691452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_000642.3; NM_000651.4. DR SMR; E9PDY4; -. DR MassIVE; E9PDY4; -. DR PaxDb; 9606-ENSP00000356016; -. DR PeptideAtlas; E9PDY4; -. DR ProteomicsDB; 19772; -. DR Antibodypedia; 4269; 1484 antibodies from 45 providers. DR DNASU; 1378; -. DR Ensembl; ENST00000367049.9; ENSP00000356016.4; ENSG00000203710.12. DR GeneID; 1378; -. DR MANE-Select; ENST00000367049.9; ENSP00000356016.4; NM_000651.6; NP_000642.3. DR UCSC; uc001hfx.4; human. DR CTD; 1378; -. DR HGNC; HGNC:2334; CR1. DR NIAGADS; ENSG00000203710; -. DR VEuPathDB; HostDB:ENSG00000203710; -. DR GeneTree; ENSGT00940000160375; -. DR OMA; ITCNRPD; -. DR OrthoDB; 5395408at2759; -. DR PhylomeDB; E9PDY4; -. DR TreeFam; TF316872; -. DR BioGRID-ORCS; 1378; 11 hits in 1151 CRISPR screens. DR ChiTaRS; CR1; human. DR GenomeRNAi; 1378; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000203710; Expressed in blood and 123 other cell types or tissues. DR ExpressionAtlas; E9PDY4; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd00033; CCP; 37. DR Gene3D; 2.10.70.10; Complement Module, domain 1; 37. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR PANTHER; PTHR19325:SF534; COMPLEMENT COMPONENT RECEPTOR 1-LIKE PROTEIN; 1. DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1. DR Pfam; PF00084; Sushi; 37. DR SMART; SM00032; CCP; 37. DR SUPFAM; SSF57535; Complement control module/SCR domain; 37. DR PROSITE; PS50923; SUSHI; 37. DR Genevisible; E9PDY4; HS. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|MaxQB:E9PDY4, KW ECO:0007829|PeptideAtlas:E9PDY4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE- KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..41 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 42..2489 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003244036" FT TRANSMEM 2422..2446 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 41..101 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 102..163 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 164..234 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 236..293 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 295..355 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 356..418 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 419..489 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 491..551 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 552..613 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 614..684 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 686..743 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 745..805 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 806..868 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 869..939 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 941..1001 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1002..1063 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1064..1134 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1136..1193 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1195..1255 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1256..1318 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1319..1389 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1391..1451 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1452..1513 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1514..1584 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1586..1643 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1645..1705 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1706..1768 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1769..1839 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1844..1904 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1905..1966 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 1967..2037 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 2039..2096 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 2098..2158 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 2159..2221 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 2222..2292 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 2296..2356 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT DOMAIN 2357..2417 FT /note="Sushi" FT /evidence="ECO:0000259|PROSITE:PS50923" FT REGION 2467..2489 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2470..2489 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 43..86 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 266..293 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 297..340 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 326..353 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 493..536 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 716..743 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 747..790 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 776..803 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 943..986 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1166..1193 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1197..1240 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1226..1253 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1393..1436 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1616..1643 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1647..1690 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1676..1703 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 1846..1889 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2069..2096 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2100..2143 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2129..2156 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2298..2341 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2327..2354 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2359..2402 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" FT DISULFID 2388..2415 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302" SQ SEQUENCE 2489 AA; 272924 MW; B80E2DBF555E6B54 CRC64; MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI RVPGNRSFFT LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP //