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Entry version 67 (26 Feb 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Complement receptor type 1

Gene

CR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Complement receptor type 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2334 CR1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2422 – 2446HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

NIAGADS Genomics Database

More...
NIAGADSi
ENSG00000203710

Open Targets

More...
OpenTargetsi
ENSG00000203710

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Sequence analysisAdd BLAST41
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324403642 – 2489Sequence analysisAdd BLAST2448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 86PROSITE-ProRule annotation
Disulfide bondi266 ↔ 293PROSITE-ProRule annotation
Disulfide bondi297 ↔ 340PROSITE-ProRule annotation
Disulfide bondi326 ↔ 353PROSITE-ProRule annotation
Disulfide bondi493 ↔ 536PROSITE-ProRule annotation
Disulfide bondi716 ↔ 743PROSITE-ProRule annotation
Disulfide bondi747 ↔ 790PROSITE-ProRule annotation
Disulfide bondi776 ↔ 803PROSITE-ProRule annotation
Disulfide bondi943 ↔ 986PROSITE-ProRule annotation
Disulfide bondi1166 ↔ 1193PROSITE-ProRule annotation
Disulfide bondi1197 ↔ 1240PROSITE-ProRule annotation
Disulfide bondi1226 ↔ 1253PROSITE-ProRule annotation
Disulfide bondi1393 ↔ 1436PROSITE-ProRule annotation
Disulfide bondi1616 ↔ 1643PROSITE-ProRule annotation
Disulfide bondi1647 ↔ 1690PROSITE-ProRule annotation
Disulfide bondi1676 ↔ 1703PROSITE-ProRule annotation
Disulfide bondi1846 ↔ 1889PROSITE-ProRule annotation
Disulfide bondi2069 ↔ 2096PROSITE-ProRule annotation
Disulfide bondi2100 ↔ 2143PROSITE-ProRule annotation
Disulfide bondi2129 ↔ 2156PROSITE-ProRule annotation
Disulfide bondi2298 ↔ 2341PROSITE-ProRule annotation
Disulfide bondi2327 ↔ 2354PROSITE-ProRule annotation
Disulfide bondi2359 ↔ 2402PROSITE-ProRule annotation
Disulfide bondi2388 ↔ 2415PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PDY4

PeptideAtlas

More...
PeptideAtlasi
E9PDY4

PRoteomics IDEntifications database

More...
PRIDEi
E9PDY4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19772

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203710 Expressed in blood and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PDY4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PDY4 HS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PDY4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 101SushiInterPro annotationAdd BLAST61
Domaini102 – 163SushiInterPro annotationAdd BLAST62
Domaini164 – 234SushiInterPro annotationAdd BLAST71
Domaini236 – 293SushiInterPro annotationAdd BLAST58
Domaini295 – 355SushiInterPro annotationAdd BLAST61
Domaini356 – 418SushiInterPro annotationAdd BLAST63
Domaini419 – 489SushiInterPro annotationAdd BLAST71
Domaini491 – 551SushiInterPro annotationAdd BLAST61
Domaini552 – 613SushiInterPro annotationAdd BLAST62
Domaini614 – 684SushiInterPro annotationAdd BLAST71
Domaini686 – 743SushiInterPro annotationAdd BLAST58
Domaini745 – 805SushiInterPro annotationAdd BLAST61
Domaini806 – 868SushiInterPro annotationAdd BLAST63
Domaini869 – 939SushiInterPro annotationAdd BLAST71
Domaini941 – 1001SushiInterPro annotationAdd BLAST61
Domaini1002 – 1063SushiInterPro annotationAdd BLAST62
Domaini1064 – 1134SushiInterPro annotationAdd BLAST71
Domaini1136 – 1193SushiInterPro annotationAdd BLAST58
Domaini1195 – 1255SushiInterPro annotationAdd BLAST61
Domaini1256 – 1318SushiInterPro annotationAdd BLAST63
Domaini1319 – 1389SushiInterPro annotationAdd BLAST71
Domaini1391 – 1451SushiInterPro annotationAdd BLAST61
Domaini1452 – 1513SushiInterPro annotationAdd BLAST62
Domaini1514 – 1584SushiInterPro annotationAdd BLAST71
Domaini1586 – 1643SushiInterPro annotationAdd BLAST58
Domaini1645 – 1705SushiInterPro annotationAdd BLAST61
Domaini1706 – 1768SushiInterPro annotationAdd BLAST63
Domaini1769 – 1839SushiInterPro annotationAdd BLAST71
Domaini1844 – 1904SushiInterPro annotationAdd BLAST61
Domaini1905 – 1966SushiInterPro annotationAdd BLAST62
Domaini1967 – 2037SushiInterPro annotationAdd BLAST71
Domaini2039 – 2096SushiInterPro annotationAdd BLAST58
Domaini2098 – 2158SushiInterPro annotationAdd BLAST61
Domaini2159 – 2221SushiInterPro annotationAdd BLAST63
Domaini2222 – 2292SushiInterPro annotationAdd BLAST71
Domaini2296 – 2356SushiInterPro annotationAdd BLAST61
Domaini2357 – 2417SushiInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2467 – 2489DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2470 – 2489PolarSequence analysisAdd BLAST20

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDF5 Eukaryota
ENOG410YE3Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160375

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNGQFTP

Database of Orthologous Groups

More...
OrthoDBi
46968at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PDY4

TreeFam database of animal gene trees

More...
TreeFami
TF316872

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 37 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 37 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 37 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 37 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 37 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9PDY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP
60 70 80 90 100
FARPTNLTDE FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR
110 120 130 140 150
RKSCRNPPDP VNGMVHVIKG IQFGSQIKYS CTKGYRLIGS SSATCIISGD
160 170 180 190 200
TVIWDNETPI CDRIPCGLPP TITNGDFIST NRENFHYGSV VTYRCNPGSG
210 220 230 240 250
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
260 270 280 290 300
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
310 320 330 340 350
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
360 370 380 390 400
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
410 420 430 440 450
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC
460 470 480 490 500
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
510 520 530 540 550
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
560 570 580 590 600
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
610 620 630 640 650
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG
660 670 680 690 700
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
710 720 730 740 750
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
760 770 780 790 800
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
810 820 830 840 850
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
860 870 880 890 900
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC
910 920 930 940 950
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
960 970 980 990 1000
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
1010 1020 1030 1040 1050
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
1060 1070 1080 1090 1100
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG
1110 1120 1130 1140 1150
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
1160 1170 1180 1190 1200
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
1210 1220 1230 1240 1250
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
1260 1270 1280 1290 1300
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
1310 1320 1330 1340 1350
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC
1360 1370 1380 1390 1400
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
1410 1420 1430 1440 1450
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
1460 1470 1480 1490 1500
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
1510 1520 1530 1540 1550
TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR
1560 1570 1580 1590 1600
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
1610 1620 1630 1640 1650
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
1660 1670 1680 1690 1700
PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA
1710 1720 1730 1740 1750
PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC
1760 1770 1780 1790 1800
VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC
1810 1820 1830 1840 1850
DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE
1860 1870 1880 1890 1900
QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED
1910 1920 1930 1940 1950
NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV
1960 1970 1980 1990 2000
SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT
2010 2020 2030 2040 2050
GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI
2060 2070 2080 2090 2100
RVPGNRSFFT LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC
2110 2120 2130 2140 2150
QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS
2160 2170 2180 2190 2200
PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA
2210 2220 2230 2240 2250
SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS
2260 2270 2280 2290 2300
YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH
2310 2320 2330 2340 2350
PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL
2360 2370 2380 2390 2400
DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS
2410 2420 2430 2440 2450
QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK
2460 2470 2480
GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP
Length:2,489
Mass (Da):272,924
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB80E2DBF555E6B54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P17927CR1_HUMAN
Complement receptor type 1
CR1 C3BR
2,039Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE06H0YE06_HUMAN
Complement receptor type 1
CR1
660Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SR44Q5SR44_HUMAN
Complement receptor type 1
CR1
2,039Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQN4E9PQN4_HUMAN
Complement receptor type 1
CR1
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL137789 Genomic DNA No translation available.
AL691452 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_000642.3, NM_000651.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367049; ENSP00000356016; ENSG00000203710

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1378

UCSC genome browser

More...
UCSCi
uc001hfx.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137789 Genomic DNA No translation available.
AL691452 Genomic DNA No translation available.
RefSeqiNP_000642.3, NM_000651.4

3D structure databases

SMRiE9PDY4
ModBaseiSearch...

Proteomic databases

jPOSTiE9PDY4
PeptideAtlasiE9PDY4
PRIDEiE9PDY4
ProteomicsDBi19772

Genome annotation databases

EnsembliENST00000367049; ENSP00000356016; ENSG00000203710
GeneIDi1378
UCSCiuc001hfx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1378
HGNCiHGNC:2334 CR1
NIAGADSiENSG00000203710
OpenTargetsiENSG00000203710

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410KDF5 Eukaryota
ENOG410YE3Q LUCA
GeneTreeiENSGT00940000160375
OMAiPNGQFTP
OrthoDBi46968at2759
PhylomeDBiE9PDY4
TreeFamiTF316872

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CR1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1378

Gene expression databases

BgeeiENSG00000203710 Expressed in blood and 134 other tissues
ExpressionAtlasiE9PDY4 baseline and differential
GenevisibleiE9PDY4 HS

Family and domain databases

CDDicd00033 CCP, 37 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 37 hits
SMARTiView protein in SMART
SM00032 CCP, 37 hits
SUPFAMiSSF57535 SSF57535, 37 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 37 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PDY4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PDY4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 26, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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