UniProtKB - E9PDR3 (E9PDR3_HUMAN)
Protein
Voltage-dependent N-type calcium channel subunit alpha
Gene
CACNA1B
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent N-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148408.12 |
HGNCi | HGNC:1389, CACNA1B |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 97 – 114 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 135 – 156 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 223 – 245 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 300 – 321 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 333 – 355 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 484 – 504 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 510 – 527 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 609 – 631 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 687 – 709 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1151 – 1169 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1189 – 1209 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1221 – 1239 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1282 – 1304 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1394 – 1419 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1475 – 1493 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1505 – 1531 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 1537 – 1557 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1599 – 1626 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 1685 – 1708 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000148408, Expressed in middle temporal gyrus and 113 other tissues |
ExpressionAtlasi | E9PDR3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1724 – 1759 | EF-handInterPro annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 816 – 1038 | DisorderedSequence analysisAdd BLAST | 223 | |
Regioni | 1054 – 1076 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1916 – 1968 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 1981 – 2182 | DisorderedSequence analysisAdd BLAST | 202 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 363 – 383 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 712 – 738 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 858 – 955 | PolyampholyteSequence analysisAdd BLAST | 98 | |
Compositional biasi | 962 – 1027 | PolyampholyteSequence analysisAdd BLAST | 66 | |
Compositional biasi | 1916 – 1945 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 2014 – 2045 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 2048 – 2064 | BasicSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2096 – 2120 | PolyampholyteSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155275 |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005447, VDCC_N_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF6, PTHR45628:SF6, 1 hit |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01631, NVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9PDR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
160 170 180 190 200
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR
460 470 480 490 500
ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA
510 520 530 540 550
MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD
560 570 580 590 600
FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV
610 620 630 640 650
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP
660 670 680 690 700
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL
710 720 730 740 750
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA
760 770 780 790 800
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA
810 820 830 840 850
TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR
860 870 880 890 900
HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP
910 920 930 940 950
EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA
960 970 980 990 1000
KGERRARHRG GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE
1010 1020 1030 1040 1050
ATEKEAEIVE ADKEKELRNH QPREPHCDLE TSGTVTVGPM HTLPSTCLQK
1060 1070 1080 1090 1100
VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI PVMLTGPLGE ATVVPSGNVD
1110 1120 1130 1140 1150
LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR
1160 1170 1180 1190 1200
YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI
1210 1220 1230 1240 1250
KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL
1260 1270 1280 1290 1300
RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA
1310 1320 1330 1340 1350
VQLFKGKFFY CTDESKELER DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN
1360 1370 1380 1390 1400
VLWALLTLFT VSTGEGWPMV LKHSVDATYE EQGPSPGYRM ELSIFYVVYF
1410 1420 1430 1440 1450
VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI DFAISAKPLT
1460 1470 1480 1490 1500
RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE
1510 1520 1530 1540 1550
LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI
1560 1570 1580 1590 1600
LVTEIAVKNN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP
1610 1620 1630 1640 1650
YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR
1660 1670 1680 1690 1700
SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML
1710 1720 1730 1740 1750
NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF
1760 1770 1780 1790 1800
EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR
1810 1820 1830 1840 1850
TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT
1860 1870 1880 1890 1900
VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT
1910 1920 1930 1940 1950
QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE
1960 1970 1980 1990 2000
ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA
2010 2020 2030 2040 2050
SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASSH
2060 2070 2080 2090 2100
HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR
2110 2120 2130 2140 2150
ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT
2160 2170 2180 2190 2200
SPTAGQEPGP HPQAGSAVGF PNTTPCCRET PSASPWPLAL ELALTLTWGS
2210 2220 2230
VWTVRPLSTP CLRTLSLSRR LWPPTRAAPP GLPTCPP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ00975 | CAC1B_HUMAN | Voltage-dependent N-type calcium ch... | CACNA1B CACH5, CACNL1A5 | 2,339 | Annotation score: | ||
F6RH32 | F6RH32_HUMAN | Voltage-dependent N-type calcium ch... | CACNA1B | 2,340 | Annotation score: | ||
B1AQK6 | B1AQK6_HUMAN | Voltage-dependent N-type calcium ch... | CACNA1B | 2,337 | Annotation score: | ||
B1AQK7 | B1AQK7_HUMAN | Voltage-dependent N-type calcium ch... | CACNA1B | 2,338 | Annotation score: | ||
H0Y7I8 | H0Y7I8_HUMAN | Voltage-dependent N-type calcium ch... | CACNA1B | 164 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591424 Genomic DNA No translation available. AL772363 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000277549; ENSP00000277549; ENSG00000148408 |
UCSCi | uc064xnx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591424 Genomic DNA No translation available. AL772363 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9PDR3 |
PRIDEi | E9PDR3 |
ProteomicsDBi | 19730 |
Protocols and materials databases
Antibodypediai | 32538, 120 antibodies |
Genome annotation databases
Ensembli | ENST00000277549; ENSP00000277549; ENSG00000148408 |
UCSCi | uc064xnx.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148408.12 |
HGNCi | HGNC:1389, CACNA1B |
OpenTargetsi | ENSG00000148408 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155275 |
Miscellaneous databases
ChiTaRSi | CACNA1B, human |
Gene expression databases
Bgeei | ENSG00000148408, Expressed in middle temporal gyrus and 113 other tissues |
ExpressionAtlasi | E9PDR3, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005447, VDCC_N_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF6, PTHR45628:SF6, 1 hit |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01631, NVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PDR3_HUMAN | |
Accessioni | E9PDR3Primary (citable) accession number: E9PDR3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | December 2, 2020 | |
This is version 78 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |