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Entry version 62 (31 Jul 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

NAD(P) transhydrogenase, mitochondrial

Gene

NNT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NAD(P) transhydrogenase, mitochondrialImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NNTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7863 NNT

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei373 – 392HelicalSequence analysisAdd BLAST20
Transmembranei399 – 420HelicalSequence analysisAdd BLAST22
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Transmembranei466 – 485HelicalSequence analysisAdd BLAST20
Transmembranei491 – 508HelicalSequence analysisAdd BLAST18
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Transmembranei572 – 593HelicalSequence analysisAdd BLAST22
Transmembranei609 – 628HelicalSequence analysisAdd BLAST20
Transmembranei648 – 666HelicalSequence analysisAdd BLAST19
Transmembranei727 – 748HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000112992

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9PCX7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PCX7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PCX7

PeptideAtlas

More...
PeptideAtlasi
E9PCX7

PRoteomics IDEntifications database

More...
PRIDEi
E9PCX7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
19539

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9PCX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112992 Expressed in 221 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PCX7 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 241AlaDh_PNT_CInterPro annotationAdd BLAST165

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEMU Eukaryota
COG1282 LUCA
COG3288 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004624

Database of Orthologous Groups

More...
OrthoDBi
220278at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008143 Ala_DH/PNT_CS2
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR036291 NAD(P)-bd_dom_sf
IPR026255 NADP_transhyd_a
IPR024605 NADP_transhyd_a_C
IPR034300 PNTB-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PF02233 PNTB, 1 hit
PF12769 PNTB_4TM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01002 AlaDh_PNT_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit
SSF52467 SSF52467, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00561 pntA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00837 ALADH_PNT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9PCX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNPTLGVHE ADLLKTSGTL ISFIYPAQNP ELLNKLSQRK TTVLAMDQVP
60 70 80 90 100
RVTIAQGYDA LSSMANIAGY KAVVLAANHF GRFFTGQITA AGKVPPAKIL
110 120 130 140 150
IVGGGVAGLA SAGAAKSMGA IVRGFDTRAA ALEQFKSLGA EPLEVDLKES
160 170 180 190 200
GEGQGGYAKE MSKEFIEAEM KLFAQQCKEV DILISTALIP GKKAPVLFNK
210 220 230 240 250
EMIESMKEGS VVVDLAAEAG GNFETTKPGE LYIHKGITHI GYTDLPSRMA
260 270 280 290 300
TQASTLYSNN ITKLLKAISP DKDNFYFDVK DDFDFGTMGH VIRGTVVMKD
310 320 330 340 350
GKVIFPAPTP KNIPQGAPVK QKTVAELEAE KAATITPFRK TMSTASAYTA
360 370 380 390 400
GLTGILGLGI AAPNLAFSQM VTTFGLAGIV GYHTVWGVTP ALHSPLMSVT
410 420 430 440 450
NAISGLTAVG GLALMGGHLY PSTTSQGLAA LAAFISSVNI AGGFLVTQRM
460 470 480 490 500
LDMFKRPTDP PEYNYLYLLP AGTFVGGYLA ALYSGYNIEQ IMYLGSGLCC
510 520 530 540 550
VGALAGLSTQ GTARLGNALG MIGVAGGLAA TLGVLKPGPE LLAQMSGAMA
560 570 580 590 600
LGGTIGLTIA KRIQISDLPQ LVAAFHSLVG LAAVLTCIAE YIIEYPHFAT
610 620 630 640 650
DAAANLTKIV AYLGTYIGGV TFSGSLIAYG KLQGLLKSAP LLLPGRHLLN
660 670 680 690 700
AGLLAASVGG IIPFMVDPSF TTGITCLGSV SALSAVMGVT LTAAIGGADM
710 720 730 740 750
PVVITVLNSY SGWALCAEGF LLNNNLLTIV GALIGSSGAI LSYIMCVAMN
760 770 780 790 800
RSLANVILGG YGTTSTAGGK PMEISGTHTE INLDNAIDMI REANSIIITP
810 820 830 840 850
GYGLCAAKAQ YPIADLVKML TEQGKKVRFG IHPVAGRMPG QLNVLLAEAG
860 870 880 890 900
VPYDIVLEMD EINHDFPDTD LVLVIGANDT VNSAAQEDPN SIIAGMPVLE
910 920 930 940 950
VWKSKQVIVM KRSLGVGYAA VDNPIFYKPN TAMLLGDAKK TCDALQAKVR

ESYQK
Length:955
Mass (Da):99,729
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA59856439D9CE1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13423NNTM_HUMAN
NAD(P) transhydrogenase, mitochondr...
NNT
1,086Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAI5D6RAI5_HUMAN
NAD(P) transhydrogenase, mitochondr...
NNT
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHU2D6RHU2_HUMAN
NAD(P) transhydrogenase, mitochondr...
NNT
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCR6D6RCR6_HUMAN
NAD(P) transhydrogenase, mitochondr...
NNT
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9R2H0Y9R2_HUMAN
NAD(P) transhydrogenase, mitochondr...
NNT
11Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010435 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001317955.1, NM_001331026.1
XP_006714524.1, XM_006714461.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000512996; ENSP00000426343; ENSG00000112992

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23530

UCSC genome browser

More...
UCSCi
uc063dke.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010435 Genomic DNA No translation available.
RefSeqiNP_001317955.1, NM_001331026.1
XP_006714524.1, XM_006714461.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiE9PCX7

Proteomic databases

EPDiE9PCX7
jPOSTiE9PCX7
MaxQBiE9PCX7
PeptideAtlasiE9PCX7
PRIDEiE9PCX7
ProteomicsDBi19539

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000512996; ENSP00000426343; ENSG00000112992
GeneIDi23530
UCSCiuc063dke.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23530
HGNCiHGNC:7863 NNT
OpenTargetsiENSG00000112992

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEMU Eukaryota
COG1282 LUCA
COG3288 LUCA
GeneTreeiENSGT00390000004624
OrthoDBi220278at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NNT human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23530

Gene expression databases

BgeeiENSG00000112992 Expressed in 221 organ(s), highest expression level in heart
ExpressionAtlasiE9PCX7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008143 Ala_DH/PNT_CS2
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR036291 NAD(P)-bd_dom_sf
IPR026255 NADP_transhyd_a
IPR024605 NADP_transhyd_a_C
IPR034300 PNTB-like
PfamiView protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PF02233 PNTB, 1 hit
PF12769 PNTB_4TM, 1 hit
SMARTiView protein in SMART
SM01002 AlaDh_PNT_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52467 SSF52467, 1 hit
TIGRFAMsiTIGR00561 pntA, 1 hit
PROSITEiView protein in PROSITE
PS00837 ALADH_PNT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PCX7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PCX7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 31, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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