UniProtKB - E9PCW1 (E9PCW1_HUMAN)
Protein
Golgi SNAP receptor complex member 1
Gene
GOSR1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.UniRule annotation
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: InterPro
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transportUniRule annotation, Protein transportUniRule annotationARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi SNAP receptor complex member 1UniRule annotation |
Gene namesi | Name:GOSR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108587.14 |
HGNCi | HGNC:4430, GOSR1 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane UniRule annotation
Other locations
- Membrane ARBA annotation; Single-pass type IV membrane protein ARBA annotation
Golgi apparatus
- cis-Golgi network Source: InterPro
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 229 – 247 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Golgi apparatusUniRule annotationARBA annotation, MembranePTM / Processingi
Proteomic databases
EPDi | E9PCW1 |
MaxQBi | E9PCW1 |
PeptideAtlasi | E9PCW1 |
PRIDEi | E9PCW1 |
ProteomicsDBi | 19528 |
PTM databases
iPTMneti | E9PCW1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108587, Expressed in prostate gland and 250 other tissues |
ExpressionAtlasi | E9PCW1, baseline and differential |
Genevisiblei | E9PCW1, HS |
Interactioni
Subunit structurei
Component of several multiprotein Golgi SNARE complexes.
UniRule annotationProtein-protein interaction databases
IntActi | E9PCW1, 21 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 60 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 72 – 92 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000008688 |
OrthoDBi | 1319902at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR023601, Golgi_SNAP_su1 |
PANTHERi | PTHR21094, PTHR21094, 1 hit |
PIRSFi | PIRSF027109, Golgi_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9PCW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGTSSYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS STRDGRRDSS
60 70 80 90 100
DTTPLLNGSS QDRMFETMAI EIEQLLARLT GVNDKMAEYT NSAGVPSLNA
110 120 130 140 150
ALMHTLQRHR DILQDYTHEF HKTKANFMAI RERENLMGSV RKDIESYKSG
160 170 180 190 200
SGVNNRRTEL FLKEHDHLRN SDRLIEETIS IAMATKENMT SQRGMLKSIH
210 220 230 240
SKMNTLANRF PAVNSLIQRI NLRKRRDSLI LGGVIGICTI LLLLYAFH
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO95249 | GOSR1_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 GS28 | 250 | Annotation score: | ||
K7EJC8 | K7EJC8_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 236 | Annotation score: | ||
G5E9T8 | G5E9T8_HUMAN | 28 kDa Golgi SNARE protein | GOSR1 | 255 | Annotation score: | ||
B4DQA8 | B4DQA8_HUMAN | 28 kDa Golgi SNARE protein | GOSR1 | 174 | Annotation score: | ||
F6RU00 | F6RU00_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 81 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006050 Genomic DNA No translation available. AC011840 Genomic DNA No translation available. |
RefSeqi | NP_001007026.1, NM_001007025.1 |
Genome annotation databases
Ensembli | ENST00000451249; ENSP00000414441; ENSG00000108587 |
GeneIDi | 9527 |
UCSCi | uc002hfd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006050 Genomic DNA No translation available. AC011840 Genomic DNA No translation available. |
RefSeqi | NP_001007026.1, NM_001007025.1 |
3D structure databases
SMRi | E9PCW1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | E9PCW1, 21 interactors |
PTM databases
iPTMneti | E9PCW1 |
Proteomic databases
EPDi | E9PCW1 |
MaxQBi | E9PCW1 |
PeptideAtlasi | E9PCW1 |
PRIDEi | E9PCW1 |
ProteomicsDBi | 19528 |
Protocols and materials databases
Antibodypediai | 15149, 176 antibodies |
Genome annotation databases
Ensembli | ENST00000451249; ENSP00000414441; ENSG00000108587 |
GeneIDi | 9527 |
UCSCi | uc002hfd.4, human |
Organism-specific databases
CTDi | 9527 |
EuPathDBi | HostDB:ENSG00000108587.14 |
HGNCi | HGNC:4430, GOSR1 |
OpenTargetsi | ENSG00000108587 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000008688 |
OrthoDBi | 1319902at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9527, 24 hits in 848 CRISPR screens |
ChiTaRSi | GOSR1, human |
GenomeRNAii | 9527 |
Gene expression databases
Bgeei | ENSG00000108587, Expressed in prostate gland and 250 other tissues |
ExpressionAtlasi | E9PCW1, baseline and differential |
Genevisiblei | E9PCW1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR023601, Golgi_SNAP_su1 |
PANTHERi | PTHR21094, PTHR21094, 1 hit |
PIRSFi | PIRSF027109, Golgi_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PCW1_HUMAN | |
Accessioni | E9PCW1Primary (citable) accession number: E9PCW1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |