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Protein
Submitted name:

Tenascin

Gene

TNC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
TenascinImported
Gene namesi
Name:TNCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000041982.15
HGNCiHGNC:5318 TNC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000041982

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500324401620 – 1928Sequence analysisAdd BLAST1909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi190 ↔ 200PROSITE-ProRule annotation
Disulfide bondi207 ↔ 216PROSITE-ProRule annotation
Disulfide bondi284 ↔ 294PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi377 ↔ 387PROSITE-ProRule annotation
Disulfide bondi394 ↔ 403PROSITE-ProRule annotation
Disulfide bondi470 ↔ 480PROSITE-ProRule annotation
Disulfide bondi487 ↔ 496PROSITE-ProRule annotation
Disulfide bondi563 ↔ 573PROSITE-ProRule annotation
Disulfide bondi580 ↔ 589PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiE9PC84
PeptideAtlasiE9PC84
PRIDEiE9PC84

Expressioni

Gene expression databases

BgeeiENSG00000041982 Expressed in 213 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiE9PC84 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PC84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 217EGF-likeInterPro annotationAdd BLAST32
Domaini280 – 311EGF-likeInterPro annotationAdd BLAST32
Domaini373 – 404EGF-likeInterPro annotationAdd BLAST32
Domaini466 – 497EGF-likeInterPro annotationAdd BLAST32
Domaini559 – 590EGF-likeInterPro annotationAdd BLAST32
Domaini625 – 715Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini716 – 804Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini805 – 894Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini895 – 990Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini991 – 1075Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini1076 – 1165Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1167 – 1256Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1258 – 1350Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1351 – 1438Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1439 – 1528Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1529 – 1615Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1616 – 1704Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1702 – 1917Fibrinogen C-terminalInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 139Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00920000148942

Family and domain databases

CDDicd00063 FN3, 12 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR19143:SF38 PTHR19143:SF38, 6 hits
PfamiView protein in Pfam
PF07974 EGF_2, 6 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 12 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 12 hits
SUPFAMiSSF49265 SSF49265, 9 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E9PC84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF
60 70 80 90 100
NHVYNIKLPV GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TAGAGCCLQP
160 170 180 190 200
ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGRC
210 220 230 240 250
IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE GYAGADCSRE
260 270 280 290 300
ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV
310 320 330 340 350
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC
360 370 380 390 400
HTQGRCEEGQ CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG
410 420 430 440 450
ADCGELKCPN GCSGHGRCVN GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV
460 470 480 490 500
EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC VNGMCVCDDG YTGEDCRDRQ
510 520 530 540 550
CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG RCVNGQCVCH
560 570 580 590 600
EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN
610 620 630 640 650
LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLVVYTPTH EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK
710 720 730 740 750
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT
810 820 830 840 850
TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID
860 870 880 890 900
LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR
910 920 930 940 950
RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS
1010 1020 1030 1040 1050
LTLLWKTPLA KFDRYRLNYS LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN
1060 1070 1080 1090 1100
VLLTAEKGRH KSKPARVKAS TEQAPELENL TVTEVGWDGL RLNWTAADQA
1110 1120 1130 1140 1150
YEHFIIQVQE ANKVEAARNL TVPGSLRAVD IPGLKAATPY TVSIYGVIQG
1160 1170 1180 1190 1200
YRTPVLSAEA STGETPNLGE VVVAEVGWDA LKLNWTAPEG AYEYFFIQVQ
1210 1220 1230 1240 1250
EADTVEAAQN LTVPGGLRST DLPGLKAATH YTITIRGVTQ DFSTTPLSVE
1260 1270 1280 1290 1300
VLTEEVPDMG NLTVTEVSWD ALRLNWTTPD GTYDQFTIQV QEADQVEEAH
1310 1320 1330 1340 1350
NLTVPGSLRS MEIPGLRAGT PYTVTLHGEV RGHSTRPLAV EVVTEDLPQL
1360 1370 1380 1390 1400
GDLAVSEVGW DGLRLNWTAA DNAYEHFVIQ VQEVNKVEAA QNLTLPGSLR
1410 1420 1430 1440 1450
AVDIPGLEAA TPYRVSIYGV IRGYRTPVLS AEASTAMGSP KEVIFSDITE
1460 1470 1480 1490 1500
NSATVSWRAP TAQVESFRIT YVPITGGTPS MVTVDGTKTQ TRLVKLIPGV
1510 1520 1530 1540 1550
EYLVSIIAMK GFEESEPVSG SFTTALDGPS GLVTANITDS EALARWQPAI
1560 1570 1580 1590 1600
ATVDSYVISY TGEKVPEITR TVSGNTVEYA LTDLEPATEY TLRIFAEKGP
1610 1620 1630 1640 1650
QKSSTITAKF TTDLDSPRDL TATEVQSETA LLTWRPPRAS VTGYLLVYES
1660 1670 1680 1690 1700
VDGTVKEVIV GPDTTSYSLA DLSPSTHYTA KIQALNGPLR SNMIQTIFTT
1710 1720 1730 1740 1750
IGLLYPFPKD CSQAMLNGDT TSGLYTIYLN GDKAEALEVF CDMTSDGGGW
1760 1770 1780 1790 1800
IVFLRRKNGR ENFYQNWKAY AAGFGDRREE FWLGLDNLNK ITAQGQYELR
1810 1820 1830 1840 1850
VDLRDHGETA FAVYDKFSVG DAKTRYKLKV EGYSGTAGDS MAYHNGRSFS
1860 1870 1880 1890 1900
TFDKDTDSAI TNCALSYKGA FWYRNCHRVN LMGRYGDNNH SQGVNWFHWK
1910 1920
GHEHSIQFAE MKLRPSNFRN LEGRRKRA
Length:1,928
Mass (Da):210,854
Last modified:April 5, 2011 - v1
Checksum:i141AD591043D1CB4
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P24821TENA_HUMAN
Tenascin
TNC HXB
2,201Annotation score:
J3QSU6J3QSU6_HUMAN
Tenascin
TNC
2,019Annotation score:
F5H7V9F5H7V9_HUMAN
Tenascin
TNC
1,838Annotation score:
H0YGZ3H0YGZ3_HUMAN
Tenascin
TNC
615Annotation score:
F5H5D6F5H5D6_HUMAN
Tenascin
TNC
92Annotation score:
A0A0U1RR80A0A0U1RR80_HUMAN
Tenascin
TNC
23Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162425 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000423613; ENSP00000411406; ENSG00000041982
UCSCiuc010mvf.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162425 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PC84
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9PC84
PeptideAtlasiE9PC84
PRIDEiE9PC84

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423613; ENSP00000411406; ENSG00000041982
UCSCiuc010mvf.5 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000041982.15
HGNCiHGNC:5318 TNC
OpenTargetsiENSG00000041982
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000148942

Miscellaneous databases

ChiTaRSiTNC human
GenomeRNAii3371

Gene expression databases

BgeeiENSG00000041982 Expressed in 213 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiE9PC84 baseline and differential

Family and domain databases

CDDicd00063 FN3, 12 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR19143:SF38 PTHR19143:SF38, 6 hits
PfamiView protein in Pfam
PF07974 EGF_2, 6 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 12 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 12 hits
SUPFAMiSSF49265 SSF49265, 9 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PC84_HUMAN
AccessioniPrimary (citable) accession number: E9PC84
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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