UniProtKB - E9PC69 (E9PC69_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
MARK2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 82 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | E9PC69 |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:MARK2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3332, MARK2 |
VEuPathDBi | HostDB:ENSG00000072518.20 |
Subcellular locationi
Other locations
- dendrite ARBA annotation
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- dendrite Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projectionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000072518, Expressed in esophagus mucosa and 160 other tissues |
ExpressionAtlasi | E9PC69, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 304 | Protein kinaseInterPro annotationAdd BLAST | 252 | |
Domaini | 323 – 362 | UBAInterPro annotationAdd BLAST | 40 | |
Domaini | 729 – 778 | KA1InterPro annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 373 – 632 | DisorderedSequence analysisAdd BLAST | 260 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 378 – 429 | PolarSequence analysisAdd BLAST | 52 | |
Compositional biasi | 430 – 446 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 464 – 632 | PolarSequence analysisAdd BLAST | 169 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155031 |
OMAi | TMLNAAP |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
E9PC69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI
60 70 80 90 100
GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE
110 120 130 140 150
VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK
160 170 180 190 200
EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF
210 220 230 240 250
TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF
260 270 280 290 300
DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
310 320 330 340 350
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR
360 370 380 390 400
YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS
410 420 430 440 450
ANPKQRRFSD QAGPAIPTSN SYSKKTQSNN AENKRPEEDR ESGRKASSTA
460 470 480 490 500
KVPASPLPGL ERKKTTPTPS TNSVLSTSTN RSRNSPLLER ASLGQASIQN
510 520 530 540 550
GKDSLTMPGS RASTASASAA VSAARPRQHQ KSMSASVHPN KASGLPPTES
560 570 580 590 600
NCEVPRPSTA PQRVPVASPS AHNISSSGGA PDRTNFPRGV SSRSTFHAGQ
610 620 630 640 650
LRQVRDQQNL PYGVTPASPS GHSQGRRGAS GSIFSKFTSK FVRRNLNEPE
660 670 680 690 700
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM
710 720 730 740 750
MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL
760 770
NGVRFKRISG TSMAFKNIAS KIANELKL
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7KZI7 | MARK2_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 EMK1 | 788 | Annotation score: | ||
E7ETY4 | E7ETY4_HUMAN | Non-specific serine/threonine prote... | MARK2 | 763 | Annotation score: | ||
F5H4F6 | F5H4F6_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 161 | Annotation score: | ||
F5H6N2 | F5H6N2_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 111 | Annotation score: | ||
F5H4J8 | F5H4J8_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 91 | Annotation score: | ||
A0A1B0GXH6 | A0A1B0GXH6_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 60 | Annotation score: | ||
A0A0A0MRU9 | A0A0A0MRU9_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 732 | Annotation score: | ||
A0A7I2V3R3 | A0A7I2V3R3_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 561 | Annotation score: | ||
A0A7I2YQF3 | A0A7I2YQF3_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 128 | Annotation score: | ||
A0A7I2YQR3 | A0A7I2YQR3_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 718 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003780 Genomic DNA No translation available. AP006289 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000502399; ENSP00000423452; ENSG00000072518 |
UCSCi | uc058cry.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003780 Genomic DNA No translation available. AP006289 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | E9PC69, 5 interactors |
Proteomic databases
EPDi | E9PC69 |
MaxQBi | E9PC69 |
PeptideAtlasi | E9PC69 |
ProteomicsDBi | 19381 |
Protocols and materials databases
Antibodypediai | 15193, 463 antibodies |
Genome annotation databases
Ensembli | ENST00000502399; ENSP00000423452; ENSG00000072518 |
UCSCi | uc058cry.1, human |
Organism-specific databases
HGNCi | HGNC:3332, MARK2 |
OpenTargetsi | ENSG00000072518 |
VEuPathDBi | HostDB:ENSG00000072518.20 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155031 |
OMAi | TMLNAAP |
Enzyme and pathway databases
SignaLinki | E9PC69 |
Miscellaneous databases
ChiTaRSi | MARK2, human |
Gene expression databases
Bgeei | ENSG00000072518, Expressed in esophagus mucosa and 160 other tissues |
ExpressionAtlasi | E9PC69, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PC69_HUMAN | |
Accessioni | E9PC69Primary (citable) accession number: E9PC69 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 87 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |