UniProtKB - E9PC54 (E9PC54_HUMAN)
Protein
Submitted name:
Guanine nucleotide-binding protein subunit alpha-12
Gene
GNA12
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: InterPro
- GTPase activity Source: InterPro
- guanyl nucleotide binding Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | TransducerARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Guanine nucleotide-binding protein subunit alpha-12Imported |
Gene namesi | Name:GNA12Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000146535.13 |
HGNCi | HGNC:4380, GNA12 |
PTM / Processingi
Proteomic databases
MaxQBi | E9PC54 |
PeptideAtlasi | E9PC54 |
PRIDEi | E9PC54 |
ProteomicsDBi | 19370 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146535, Expressed in secondary oocyte and 231 other tissues |
ExpressionAtlasi | E9PC54, baseline and differential |
Family & Domainsi
Phylogenomic databases
GeneTreei | ENSGT00940000157636 |
HOGENOMi | CLU_912030_0_0_1 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
InterProi | View protein in InterPro IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E9PC54-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRAGLGAG PLLLRSRADW VCGGWEAALS APPPFCTAWV ERTGLVHFLR
60 70 80 90 100
EGGHGACFPL ALLHPGSVVS FQMIYPLIVL PLCASWHWGL IRKGIVLFWG
110 120 130 140 150
ESVKYFLDNL DRIGQLNYFP SKQDILLARK ATKGIVEHDF VIKKIPFKMV
160 170 180 190 200
DVGGQRSQRQ KWFQCFDGIT SILFMVSSSE YDQVLMEDRR TNRLVESMNI
210 220 230 240 250
FETIVNNKLF FNVSIILFLN KMDLLVEKVK TVSIKKHFPD FRGDPHRLED
260 270 280 290 300
VQRYLVQCFD RKRRNRSKPL FHHFTTAIDT ENVRFVFHAV KDTILQENLK
DIMLQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ03113 | GNA12_HUMAN | Guanine nucleotide-binding protein ... | GNA12 | 381 | Annotation score: | ||
C9J2Y7 | C9J2Y7_HUMAN | Guanine nucleotide-binding protein ... | GNA12 | 77 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006028 Genomic DNA No translation available. |
RefSeqi | NP_001269369.1, NM_001282440.1 |
Genome annotation databases
Ensembli | ENST00000407653; ENSP00000386054; ENSG00000146535 |
GeneIDi | 2768 |
UCSCi | uc032zbv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006028 Genomic DNA No translation available. |
RefSeqi | NP_001269369.1, NM_001282440.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E9PC54 |
PeptideAtlasi | E9PC54 |
PRIDEi | E9PC54 |
ProteomicsDBi | 19370 |
Protocols and materials databases
Antibodypediai | 4103, 220 antibodies |
Genome annotation databases
Ensembli | ENST00000407653; ENSP00000386054; ENSG00000146535 |
GeneIDi | 2768 |
UCSCi | uc032zbv.2, human |
Organism-specific databases
CTDi | 2768 |
EuPathDBi | HostDB:ENSG00000146535.13 |
HGNCi | HGNC:4380, GNA12 |
OpenTargetsi | ENSG00000146535 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157636 |
HOGENOMi | CLU_912030_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 2768, 16 hits in 846 CRISPR screens |
ChiTaRSi | GNA12, human |
GenomeRNAii | 2768 |
Gene expression databases
Bgeei | ENSG00000146535, Expressed in secondary oocyte and 231 other tissues |
ExpressionAtlasi | E9PC54, baseline and differential |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
InterProi | View protein in InterPro IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PC54_HUMAN | |
Accessioni | E9PC54Primary (citable) accession number: E9PC54 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |