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UniProtKB - E9PC15 (E9PC15_HUMAN)
Protein
Acylglycerol kinase, mitochondrial
Gene
AGK
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- EC:2.7.1.107ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- EC:2.7.1.94ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- EC:2.7.1.138ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
Cofactori
Mg2+ARBA annotation
: glycerolipid metabolism Pathwayi
This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.
GO - Molecular functioni
- NAD+ kinase activity Source: InterPro
Enzyme and pathway databases
UniPathwayi | UPA00230 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AGK |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21869, AGK |
VEuPathDBi | HostDB:ENSG00000006530 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane ARBA annotation; Peripheral membrane protein ARBA annotation
- Mitochondrion intermembrane space ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Mitochondrion
- mitochondrion Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneARBA annotationPTM / Processingi
Proteomic databases
EPDi | E9PC15 |
MaxQBi | E9PC15 |
PeptideAtlasi | E9PC15 |
PRIDEi | E9PC15 |
ProteomicsDBi | 19341 |
Expressioni
Gene expression databases
Bgeei | ENSG00000006530, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | E9PC15, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 171 | DAGKcInterPro annotationAdd BLAST | 142 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 221 – 243 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the AGK family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000154961 |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR045579, AGK_C IPR017438, ATP-NAD_kinase_N IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf |
Pfami | View protein in Pfam PF19712, AGK_C, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
E9PC15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENTDSDNLL RRAACQEAQV FGNQLIPPNA QVKKATVFLN PAACKGKART
60 70 80 90 100
LFEKNAAPIL HLSGMDVTIV KTDYEGQAKK LLELMENTDV IIVAGGDGTL
110 120 130 140 150
QEVVTGVLRR TDEATFSKIP IGFIPLGETS SLSHTLFAES GNKVQHITDA
160 170 180 190 200
TLAIVKGETV PLDVLQIKGE KEQPVFAMTG LRWGSFRDAG VKVSKYWYLG
210 220 230 240 250
PLKIKAAHFF STLKEWPQTH QASISYTGPT ERPPNEPEET PVQRPSLYRR
260 270 280 290 300
ILRRLASYWA QPQDALSQEV SPEVWKDVQL STIELSITTR NNQLDPTSKE
310 320 330 340 350
DFLNICIEPD TISKGDFITI GSRKVRNPKL HVEGTECLQA SQCTLLIPEG
360 370 380 390
AGGSFSIDSE EYEAMPVEVK LLPRKLQFFC DPRKREQMLT SPTQ
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ53H12 | AGK_HUMAN | Acylglycerol kinase, mitochondrial | AGK MULK | 422 | Annotation score: | ||
A0A3B3ISZ0 | A0A3B3ISZ0_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 350 | Annotation score: | ||
A0A3B3ITD0 | A0A3B3ITD0_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 418 | Annotation score: | ||
A0A3B3ISY9 | A0A3B3ISY9_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 330 | Annotation score: | ||
A0A3B3ITV0 | A0A3B3ITV0_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 138 | Annotation score: | ||
E9PG39 | E9PG39_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 244 | Annotation score: | ||
A0A0G2JLG5 | A0A0G2JLG5_HUMAN | Diacylglycerol kinase (ATP) | AGK | 226 | Annotation score: | ||
A0A0G2JLD0 | A0A0G2JLD0_HUMAN | Diacylglycerol kinase (ATP) | AGK | 51 | Annotation score: | ||
A0A3B3ITX7 | A0A3B3ITX7_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 214 | Annotation score: | ||
A0A3B3IS09 | A0A3B3IS09_HUMAN | Acylglycerol kinase, mitochondrial | AGK | 146 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004918 Genomic DNA No translation available. AC073878 Genomic DNA No translation available. AC099547 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000473247.5; ENSP00000420776.1; ENSG00000006530.18 |
UCSCi | uc064iql.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004918 Genomic DNA No translation available. AC073878 Genomic DNA No translation available. AC099547 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PC15 |
ModBasei | Search... |
Proteomic databases
EPDi | E9PC15 |
MaxQBi | E9PC15 |
PeptideAtlasi | E9PC15 |
PRIDEi | E9PC15 |
ProteomicsDBi | 19341 |
Protocols and materials databases
Antibodypediai | 18305, 202 antibodies from 32 providers |
Genome annotation databases
Ensembli | ENST00000473247.5; ENSP00000420776.1; ENSG00000006530.18 |
UCSCi | uc064iql.1, human |
Organism-specific databases
HGNCi | HGNC:21869, AGK |
OpenTargetsi | ENSG00000006530 |
VEuPathDBi | HostDB:ENSG00000006530 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154961 |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
Miscellaneous databases
ChiTaRSi | AGK, human |
Gene expression databases
Bgeei | ENSG00000006530, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | E9PC15, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR045579, AGK_C IPR017438, ATP-NAD_kinase_N IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf |
Pfami | View protein in Pfam PF19712, AGK_C, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PC15_HUMAN | |
Accessioni | E9PC15Primary (citable) accession number: E9PC15 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |