UniProtKB - E9PBI9 (E9PBI9_HUMAN)
Protein
Syndecan
Gene
SDC2
Organism
Homo sapiens (Human)
Status
Functioni
Cell surface proteoglycan.UniRule annotation
Names & Taxonomyi
Protein namesi | Recommended name: SyndecanUniRule annotation |
Gene namesi | Name:SDC2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10659, SDC2 |
VEuPathDBi | HostDB:ENSG00000169439.11 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 116 – 140 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
Glycoprotein, Heparan sulfateUniRule annotationARBA annotation, ProteoglycanProteomic databases
MaxQBi | E9PBI9 |
PRIDEi | E9PBI9 |
ProteomicsDBi | 19235 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169439, Expressed in tibia and 240 other tissues |
ExpressionAtlasi | E9PBI9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 139 – 157 | 4.1mInterPro annotationAdd BLAST | 19 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 60 – 101 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 149 – 172 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 73 – 101 | PolyampholyteSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157222 |
HOGENOMi | CLU_046599_2_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031201, Syndecan-2 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF6, PTHR10915:SF6, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PBI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLDNSSIEE ASGVYPIDDD DYASASGSGA DEDVESPELT TSRPLPKILL
60 70 80 90 100
TSAAPKVETT TLNIQNKIPA QTKSPEETDK EKVHLSDSER KMDPAEEDTN
110 120 130 140 150
VYTEKHSDSL FKRTEVLAAV IAGGVIGFLF AIFLILLLVY RMRKKDEGSY
160 170
DLGERKPSSA AYQKAPTKEF YA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP34741 | SDC2_HUMAN | Syndecan-2 | SDC2 HSPG1 | 201 | Annotation score: | ||
E7ESK6 | E7ESK6_HUMAN | Syndecan | SDC2 | 165 | Annotation score: | ||
E5RHU3 | E5RHU3_HUMAN | Syndecan-2 | SDC2 | 145 | Annotation score: | ||
E5RJB8 | E5RJB8_HUMAN | Syndecan-2 | SDC2 | 137 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003477 Genomic DNA No translation available. AP003548 Genomic DNA No translation available. KC877279 Genomic DNA No translation available. |
RefSeqi | XP_011515514.1, XM_011517212.2 |
Genome annotation databases
Ensembli | ENST00000519914; ENSP00000428256; ENSG00000169439 ENST00000522911; ENSP00000427784; ENSG00000169439 |
GeneIDi | 6383 |
UCSCi | uc011lgu.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003477 Genomic DNA No translation available. AP003548 Genomic DNA No translation available. KC877279 Genomic DNA No translation available. |
RefSeqi | XP_011515514.1, XM_011517212.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E9PBI9 |
PRIDEi | E9PBI9 |
ProteomicsDBi | 19235 |
Protocols and materials databases
Antibodypediai | 25987, 284 antibodies |
DNASUi | 6383 |
Genome annotation databases
Ensembli | ENST00000519914; ENSP00000428256; ENSG00000169439 ENST00000522911; ENSP00000427784; ENSG00000169439 |
GeneIDi | 6383 |
UCSCi | uc011lgu.2, human |
Organism-specific databases
CTDi | 6383 |
HGNCi | HGNC:10659, SDC2 |
OpenTargetsi | ENSG00000169439 |
VEuPathDBi | HostDB:ENSG00000169439.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157222 |
HOGENOMi | CLU_046599_2_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 6383, 4 hits in 992 CRISPR screens |
ChiTaRSi | SDC2, human |
GenomeRNAii | 6383 |
Gene expression databases
Bgeei | ENSG00000169439, Expressed in tibia and 240 other tissues |
ExpressionAtlasi | E9PBI9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031201, Syndecan-2 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF6, PTHR10915:SF6, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PBI9_HUMAN | |
Accessioni | E9PBI9Primary (citable) accession number: E9PBI9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |