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UniProtKB - E9PBI7 (E9PBI7_HUMAN)
Protein
Submitted name:
Transient receptor potential cation channel subfamily M member 3
Gene
TRPM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium activated cation channel activity Source: InterPro
GO - Biological processi
- detection of temperature stimulus Source: InterPro
- protein tetramerization Source: InterPro
- sensory perception of temperature stimulus Source: InterPro
Keywordsi
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Transient receptor potential cation channel subfamily M member 3Imported |
Gene namesi | Name:TRPM3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17992, TRPM3 |
VEuPathDBi | HostDB:ENSG00000083067 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 745 – 764 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 812 – 830 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 842 – 860 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 881 – 901 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 959 – 984 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | E9PBI7 |
PeptideAtlasi | E9PBI7 |
PRIDEi | E9PBI7 |
ProteomicsDBi | 19233 |
Expressioni
Gene expression databases
Bgeei | ENSG00000083067, Expressed in pigmented layer of retina and 162 other tissues |
ExpressionAtlasi | E9PBI7, baseline and differential |
Genevisiblei | E9PBI7, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 290 | LSDAT_eukInterPro annotationAdd BLAST | 290 | |
Domaini | 751 – 993 | Ion_transInterPro annotationAdd BLAST | 243 | |
Domaini | 1087 – 1142 | TRPM_tetraInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1306 – 1325 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1458 – 1579 | DisorderedSequence analysisAdd BLAST | 122 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1090 – 1110 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1128 – 1148 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1306 – 1321 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1458 – 1477 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1483 – 1505 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157366 |
OrthoDBi | 738147at2759 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029583, TRPM3 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF7, PTHR13800:SF7, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
E9PBI7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF
60 70 80 90 100
GKGLIKAAMT TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP
110 120 130 140 150
WGIVENQEDL IGRDVVRPYQ TMSNPMSKLT VLNSMHSHFI LADNGTTGKY
160 170 180 190 200
GAEVKLRRQL EKHISLQKIN TRCLPFFSLD SRLFYSFWGS CQLDSVGIGQ
210 220 230 240 250
GVPVVALIVE GGPNVISIVL EYLRDTPPVP VVVCDGSGRA SDILAFGHKY
260 270 280 290 300
SEEGGLINES LRDQLLVTIQ KTFTYTRTQA QHLFIILMEC MKKKELITVF
310 320 330 340 350
RMGSEGHQDI DLAILTALLK GANASAPDQL SLALAWNRVD IARSQIFIYG
360 370 380 390 400
QQWPVGSLEQ AMLDALVLDR VDFVKLLIEN GVSMHRFLTI SRLEELYNTR
410 420 430 440 450
HGPSNTLYHL VRDVKKGNLP PDYRISLIDI GLVIEYLMGG AYRCNYTRKR
460 470 480 490 500
FRTLYHNLFG PKRPKALKLL GMEDDIPLRR GRKTTKKREE EVDIDLDDPE
510 520 530 540 550
INHFPFPFHE LMVWAVLMKR QKMALFFWQH GEEAMAKALV ACKLCKAMAH
560 570 580 590 600
EASENDMVDD ISQELNHNSR DFGQLAVELL DQSYKQDEQL AMKLLTYELK
610 620 630 640 650
NWSNATCLQL AVAAKHRDFI AHTCSQMLLT DMWMGRLRMR KNSGLKVILG
660 670 680 690 700
ILLPPSILSL EFKNKDDMPY MSQAQEIHLQ EKEAEEPEKP TKEKEEEDME
710 720 730 740 750
LTAMLGRNNG ESSRKKDEEE VQSKHRLIPL GRKIYEFYNA PIVKFWFYTL
760 770 780 790 800
AYIGYLMLFN YIVLVKMERW PSTQEWIVIS YIFTLGIEKM REILMSEPGK
810 820 830 840 850
LLQKVKVWLQ EYWNVTDLIA ILLFSVGMIL RLQDQPFRSD GRVIYCVNII
860 870 880 890 900
YWYIRLLDIF GVNKYLGPYV MMIGKMMIDM MYFVIIMLVV LMSFGVARQA
910 920 930 940 950
ILFPNEEPSW KLAKNIFYMP YWMIYGEVFA DQIDPPCGQN ETREDGKIIQ
960 970 980 990 1000
LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE VKSISNQVWK
1010 1020 1030 1040 1050
FQRYQLIMTF HERPVLPPPL IIFSHMTMIF QHLCCRWRKH ESDPDERDYG
1060 1070 1080 1090 1100
LKLFITDDEL KKVHDFEEQC IEEYFREKDD RFNSSNDERI RVTSERVENM
1110 1120 1130 1140 1150
SMRLEEVNER EHSMKASLQT VDIRLAQLED LIGRMATALE RLTGLERAES
1160 1170 1180 1190 1200
NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT FKLQESIDPA GEETMSPTSP
1210 1220 1230 1240 1250
TLMPRMRSHS FYSVNMKDKG GIEKLESIFK ERSLSLHRAT SSHSVAKEPK
1260 1270 1280 1290 1300
APAAPANTLA IVPDSRRPSS CIDIYVSAMD ELHCDIDPLD NSVNILGLGE
1310 1320 1330 1340 1350
PSFSTPVPST APSSSAYATL APTDRPPSRS IDFEDITSMD TRSFSSDYTH
1360 1370 1380 1390 1400
LPECQNPWDS EPPMYHTIER SKSSRYLATT PFLLEEAPIV KSHSFMFSPS
1410 1420 1430 1440 1450
RSYYANFGVP VKTAEYTSIT DCIDTRCVNA PQAIADRAAF PGGLGDKVED
1460 1470 1480 1490 1500
LTCCHPEREA ELSHPSSDSE ENEAKGRRAT IAISSQEGDN SERTLSNNIT
1510 1520 1530 1540 1550
VPKIERANSY SAEEPSAPYA HTRKSFSISD KLDRQRNTAS LRNPFQRSKS
1560 1570
SKPEGRGDSL SMRRLSRTSA FQSFESKHN
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9HCF6 | TRPM3_HUMAN | Transient receptor potential cation... | TRPM3 KIAA1616, LTRPC3 | 1,732 | Annotation score: | ||
A2A3F7 | A2A3F7_HUMAN | Transient receptor potential cation... | TRPM3 | 1,711 | Annotation score: | ||
A2A3F4 | A2A3F4_HUMAN | Transient receptor potential cation... | TRPM3 | 1,569 | Annotation score: | ||
G5E9G1 | G5E9G1_HUMAN | Transient receptor potential cation... | TRPM3 hCG_2042991 | 1,566 | Annotation score: | ||
H7BYP1 | H7BYP1_HUMAN | Transient receptor potential cation... | TRPM3 hCG_2042991 | 1,556 | Annotation score: | ||
A2A3F3 | A2A3F3_HUMAN | Transient receptor potential cation... | TRPM3 | 1,566 | Annotation score: | ||
A0A7I2V4E8 | A0A7I2V4E8_HUMAN | Transient receptor potential cation... | TRPM3 | 1,690 | Annotation score: | ||
A0A7I2V4C9 | A0A7I2V4C9_HUMAN | Transient receptor potential cation... | TRPM3 | 1,184 | Annotation score: | ||
H0Y3D4 | H0Y3D4_HUMAN | Transient receptor potential cation... | TRPM3 | 123 | Annotation score: | ||
Q4VXD4 | Q4VXD4_HUMAN | Transient receptor potential cation... | TRPM3 | 275 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL159990 Genomic DNA No translation available. AL160273 Genomic DNA No translation available. AL161913 Genomic DNA No translation available. AL356318 Genomic DNA No translation available. AL358786 Genomic DNA No translation available. AL391819 Genomic DNA No translation available. AL442645 Genomic DNA No translation available. AL592438 Genomic DNA No translation available. KF458923 Genomic DNA No translation available. |
RefSeqi | NP_996829.3, NM_206946.3 |
Genome annotation databases
Ensembli | ENST00000396292; ENSP00000379587; ENSG00000083067 |
GeneIDi | 80036 |
UCSCi | uc064trh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL159990 Genomic DNA No translation available. AL160273 Genomic DNA No translation available. AL161913 Genomic DNA No translation available. AL356318 Genomic DNA No translation available. AL358786 Genomic DNA No translation available. AL391819 Genomic DNA No translation available. AL442645 Genomic DNA No translation available. AL592438 Genomic DNA No translation available. KF458923 Genomic DNA No translation available. |
RefSeqi | NP_996829.3, NM_206946.3 |
3D structure databases
SMRi | E9PBI7 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9PBI7 |
PeptideAtlasi | E9PBI7 |
PRIDEi | E9PBI7 |
ProteomicsDBi | 19233 |
Protocols and materials databases
Antibodypediai | 12418, 163 antibodies from 19 providers |
DNASUi | 80036 |
Genome annotation databases
Ensembli | ENST00000396292; ENSP00000379587; ENSG00000083067 |
GeneIDi | 80036 |
UCSCi | uc064trh.1, human |
Organism-specific databases
CTDi | 80036 |
HGNCi | HGNC:17992, TRPM3 |
OpenTargetsi | ENSG00000083067 |
VEuPathDBi | HostDB:ENSG00000083067 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157366 |
OrthoDBi | 738147at2759 |
Miscellaneous databases
BioGRID-ORCSi | 80036, 3 hits in 1039 CRISPR screens |
ChiTaRSi | TRPM3, human |
GenomeRNAii | 80036 |
Gene expression databases
Bgeei | ENSG00000083067, Expressed in pigmented layer of retina and 162 other tissues |
ExpressionAtlasi | E9PBI7, baseline and differential |
Genevisiblei | E9PBI7, HS |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029583, TRPM3 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF7, PTHR13800:SF7, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PBI7_HUMAN | |
Accessioni | E9PBI7Primary (citable) accession number: E9PBI7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |