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Entry version 69 (08 May 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Gene

NACA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
E9PAV3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
Alternative name(s):
Alpha-NAC, muscle-specific form
Short name:
skNAC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NACA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7629 NACA

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_E9PAV3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4666

Open Targets

More...
OpenTargetsi
ENSG00000196531

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NACA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004255711 – 2078Nascent polypeptide-associated complex subunit alpha, muscle-specific formAdd BLAST2078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei917PhosphoserineBy similarity1
Modified residuei1181PhosphoserineBy similarity1
Modified residuei1397PhosphoserineBy similarity1
Modified residuei1474PhosphoserineBy similarity1
Modified residuei1906Phosphoserine; by ILK1By similarity1
Modified residuei1995PhosphoserineCombined sources1
Modified residuei2005N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2005Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei2022Phosphothreonine; by GSK3-betaBy similarity1
Modified residuei2024PhosphothreonineCombined sources1
Modified residuei2029PhosphoserineCombined sources1
Modified residuei2049PhosphoserineCombined sources1
Modified residuei2054PhosphoserineCombined sources1
Modified residuei2066PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9PAV3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PAV3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PAV3

PRoteomics IDEntifications database

More...
PRIDEi
E9PAV3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
19086

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PAV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PAV3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9PAV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196531 Expressed in 241 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PAV3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PAV3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA073152
HPA073648

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PXLXP motif) with the muscle-restricted histone methyltransferase SMYD1 (via MYND-type zinc finger).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110748, 66 interactors

Protein interaction database and analysis system

More...
IntActi
E9PAV3, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000448035

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PAV3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1933 – 1998NAC-A/BPROSITE-ProRule annotationAdd BLAST66
Domaini2039 – 2078UBAAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1932 – 1943Required for DNA-bindingBy similarityAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1841 – 1845PXLXPBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 1880Pro-richAdd BLAST1840

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The proline-rich muscle-specific exon 3 contains eighteen approximate 23-AA repeats.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2239 Eukaryota
COG1308 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033468

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPLGGPK

Database of Orthologous Groups

More...
OrthoDBi
1331328at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PAV3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.70.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21713 PTHR21713, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01849 NAC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01407 NAC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51151 NAC_AB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform skNAC (identifier: E9PAV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGEATETVP ATEQELPQPQ AETAVLPMSS ALSVTAALGQ PGPTLPPPCS
60 70 80 90 100
PAPQQCPLSA ANQASPFPSP STIASTPLEV PFPQSSSGTA LPLGTAPEAP
110 120 130 140 150
TFLPNLIGPP ISPAALALAS PMIAPTLKGT PSSSAPLALV ALAPHSVQKS
160 170 180 190 200
SAFPPNLLTS PPSVAVAESG SVITLSAPIA PSEPKTNLNK VPSEVVPNPK
210 220 230 240 250
GTPSPPCIVS TVPYHCVTPM ASIQSGVASL PQTTPTTTLA IASPQVKDTT
260 270 280 290 300
ISSVLISPQN PGSLSLKGPV SPPAALSLST QSLPVVTSSQ KTAGPNTPPD
310 320 330 340 350
FPISLGSHLA PLHQSSFGSV QLLGQTGPSA LSDPTVKTIS VDHSSTGASY
360 370 380 390 400
PSQRSVIPPL PSRNEVVPAT VAAFPVVAPS VDKGPSTISS ITCSPSGSLN
410 420 430 440 450
VATSFSLSPT TSLILKSSPN ATYHYPLVAQ MPVSSVGTTP LVVTNPCTIA
460 470 480 490 500
AAPTTTFEVA TCVSPPMSSG PISNIEPTSP AALVMAPVAP KEPSTQVATT
510 520 530 540 550
LRIPVSPPLP DPEDLKNLPS SVLVKFPTQK DLQTVPASLE GAPFSPAQAG
560 570 580 590 600
LTTKKDPTVL PLVQAAPKNS PSFQSTSSSP EIPLSPEATL AKKSLGEPLP
610 620 630 640 650
IGKPASSMTS PLGVNSSASV IKTDSYAGPD SAGPLLKSSL ITPTVAAFPL
660 670 680 690 700
ESADPAGVAP TTAKGTSTYT TTASPFLEGT VSLAPKNHPV KEGTLTTLPL
710 720 730 740 750
VPTASENCPV APSPQNTCAP LATLVLAPEI PKSVPSPSLP PAGTPPGTKK
760 770 780 790 800
VDGISHTSAL APVASSPKEC PTEDSGASAT ASSKGTLTYL ADSPSPLGVS
810 820 830 840 850
VSPQTKRPPT KKGSAGPDTP IGNLSSPVSP VEASFLPENS LSFQGSKDSP
860 870 880 890 900
ATTHSPTPPS PKGAPTPSAV TPLSPKGVTL PPKETPTPSV VNLPFPKEGP
910 920 930 940 950
ATPAPKQAPA LSMTSSSPKK ARATPAPKGI PASPSPKGAP TPPAATPPSP
960 970 980 990 1000
KGGPATPSPK WAPTPPAATP PSPKGGPATP SPKGAPTPPA ATPPSPKGGP
1010 1020 1030 1040 1050
ATPSPKGAPT PPAVTPPSPK GSPAATPFPK GASTPPAATP PSPKGSPAAT
1060 1070 1080 1090 1100
PLPKGAPTTP AATLPSPKGG PATPSLKGAP TPPAATPPSP KGGPATPSPK
1110 1120 1130 1140 1150
GAPMPPAATP PSPKGGLATP PHKGAPTTPA ATPPSPKGGL ATPPPKGAPT
1160 1170 1180 1190 1200
TPAATPPSPK GGLATPPPKG APTTPAATPP SPKGGLATPS PKGAPTTPAA
1210 1220 1230 1240 1250
TPPSPKGGLA TPSPKGAPTT PAATPPSPKG GLATPSPKGA PTTPAATPPS
1260 1270 1280 1290 1300
PKGGPATPPP KGAPTPPAAT PPSLKGGLAT PPHKGAPNPA VVTPPSPKGG
1310 1320 1330 1340 1350
PATSPPKGAP TPPAATPPSP KGSPGTPPPK GAPTPPAVTP PSPKGTPTLP
1360 1370 1380 1390 1400
ATTPSSKGGP TTPSSKEGPT PPAATPSHKG GPAMTPPSPK RGPAIPSPKG
1410 1420 1430 1440 1450
DPTSPAVIPL SPKKAPATPV TREGAATPSK GDLTPPAVTP VSLKKAPATS
1460 1470 1480 1490 1500
APKGGPATPS SKGDPTLPAV TPPSPKEPPA PKQVATSSSP KKAPATPAPM
1510 1520 1530 1540 1550
GAPTLPAVIP SSPKEVPATP SSRRDPIAPT ATLLSKKTPA TLAPKEALIP
1560 1570 1580 1590 1600
PAMTVPSPKK TPAIPTPKEA PATPSSKEAS SPPAVTPSTY KGAPSPKELL
1610 1620 1630 1640 1650
IPPAVTSPSP KEAPTPPAVT PPSPEKGPAT PAPKGTPTSP PVTPSSLKDS
1660 1670 1680 1690 1700
PTSPASVTCK MGATVPQASK GLPAKKGPTA LKEVLVAPAP ESTPIITAPT
1710 1720 1730 1740 1750
RKGPQTKKSS ATSPPICPDP SAKNGSKGPL STVAPAPLLP VQKDSSKTAK
1760 1770 1780 1790 1800
GKDASHSPKG PLAPPESKAS TPLTAAAFEK VLPKPESASV SAAPSPPVSL
1810 1820 1830 1840 1850
PLAPSPVPTL PPKQQFLPSS PGLVLESPSK PLAPADEDEL LPLIPPEPIS
1860 1870 1880 1890 1900
GGVPFQSVLV NMPTPKSAGI PVPTPSAKQP VTKNNKGSGT ESDSDESVPE
1910 1920 1930 1940 1950
LEEQDSTQAT TQQAQLAAAA EIDEEPVSKA KQSRSEKKAR KAMSKLGLRQ
1960 1970 1980 1990 2000
VTGVTRVTIR KSKNILFVIT KPDVYKSPAS DTYIVFGEAK IEDLSQQAQL
2010 2020 2030 2040 2050
AAAEKFKVQG EAVSNIQENT QTPTVQEESE EEEVDETGVE VKDIELVMSQ
2060 2070
ANVSRAKAVR ALKNNSNDIV NAIMELTM
Note: No experimental confirmation available.Curated
Length:2,078
Mass (Da):205,422
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A07C05D3F24C34B
GO
Isoform 1 (identifier: Q13765-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13765.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:215
Mass (Da):23,384
GO
Isoform skNAC-2 (identifier: E9PAV3-2) [UniParc]FASTAAdd to basket
Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     602-644: Missing.
     665-1774: Missing.

Note: No experimental confirmation available.
Show »
Length:925
Mass (Da):94,681
Checksum:i8C2A30032C1C6287
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13765NACA_HUMAN
Nascent polypeptide-associated comp...
NACA HSD48
215Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0W4F8W0W4_HUMAN
Nascent polypeptide-associated comp...
NACA
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHX9H0YHX9_HUMAN
Nascent polypeptide-associated comp...
NACA
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZJ2F8VZJ2_HUMAN
Nascent polypeptide-associated comp...
NACA
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VNW4F8VNW4_HUMAN
Nascent polypeptide-associated comp...
NACA
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZ58F8VZ58_HUMAN
Nascent polypeptide-associated comp...
NACA
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1N5F8W1N5_HUMAN
Nascent polypeptide-associated comp...
NACA
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W029F8W029_HUMAN
Nascent polypeptide-associated comp...
NACA
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0C7F8W0C7_HUMAN
Nascent polypeptide-associated comp...
NACA
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti417S → N in AK096699 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070547336V → E1 PublicationCorresponds to variant dbSNP:rs2958127Ensembl.1
Natural variantiVAR_070548405F → S1 PublicationCorresponds to variant dbSNP:rs2926743Ensembl.1
Natural variantiVAR_070549519P → S1 PublicationCorresponds to variant dbSNP:rs185561121Ensembl.1
Natural variantiVAR_0705501795S → T1 PublicationCorresponds to variant dbSNP:rs2926747Ensembl.1
Natural variantiVAR_0705511841L → P1 PublicationCorresponds to variant dbSNP:rs2958149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053722602 – 644Missing in isoform skNAC-2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_053723665 – 1774Missing in isoform skNAC-2. 1 PublicationAdd BLAST1110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096699 mRNA No translation available.
AC117378 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44925.2 [E9PAV3-2]

NCBI Reference Sequences

More...
RefSeqi
XP_011536691.1, XM_011538389.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000454682; ENSP00000403817; ENSG00000196531 [E9PAV3-1]
ENST00000550952; ENSP00000448035; ENSG00000196531 [E9PAV3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4666

UCSC genome browser

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UCSCi
uc001sma.3 human [E9PAV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096699 mRNA No translation available.
AC117378 Genomic DNA No translation available.
CCDSiCCDS44925.2 [E9PAV3-2]
RefSeqiXP_011536691.1, XM_011538389.1

3D structure databases

SMRiE9PAV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110748, 66 interactors
IntActiE9PAV3, 6 interactors
STRINGi9606.ENSP00000448035

PTM databases

iPTMnetiE9PAV3
PhosphoSitePlusiE9PAV3
SwissPalmiE9PAV3

Polymorphism and mutation databases

BioMutaiNACA

Proteomic databases

EPDiE9PAV3
jPOSTiE9PAV3
PaxDbiE9PAV3
PRIDEiE9PAV3
ProteomicsDBi19086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454682; ENSP00000403817; ENSG00000196531 [E9PAV3-1]
ENST00000550952; ENSP00000448035; ENSG00000196531 [E9PAV3-2]
GeneIDi4666
UCSCiuc001sma.3 human [E9PAV3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4666
DisGeNETi4666

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NACA
HGNCiHGNC:7629 NACA
HPAiHPA073152
HPA073648
neXtProtiNX_E9PAV3
OpenTargetsiENSG00000196531

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2239 Eukaryota
COG1308 LUCA
GeneTreeiENSGT00440000033468
OMAiDPLGGPK
OrthoDBi1331328at2759
PhylomeDBiE9PAV3

Enzyme and pathway databases

SIGNORiE9PAV3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NACA human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4666

Gene expression databases

BgeeiENSG00000196531 Expressed in 241 organ(s), highest expression level in testis
ExpressionAtlasiE9PAV3 baseline and differential
GenevisibleiE9PAV3 HS

Family and domain databases

Gene3Di2.20.70.30, 1 hit
InterProiView protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERiPTHR21713 PTHR21713, 6 hits
PfamiView protein in Pfam
PF01849 NAC, 1 hit
SMARTiView protein in SMART
SM01407 NAC, 1 hit
PROSITEiView protein in PROSITE
PS51151 NAC_AB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNACAM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PAV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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