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Entry version 77 (02 Jun 2021)
Sequence version 1 (05 Apr 2011)
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Protein

Ionotropic receptor 25a

Gene

Ir25a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection (PubMed:21220098, PubMed:27161501, PubMed:27656904).

Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b (PubMed:21220098).

Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27161501, PubMed:27656904).

Required in chordonotal organ neurons for behavioral synchronization to low-amplitude temperature cycles and mediates circadian clock resetting by temperature (PubMed:26580016).

Together with Ir40a and Ir93a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27161501, PubMed:27656904).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processBehavior, Biological rhythms, Ion transport, Olfaction, Sensory transduction, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-204005, COPII-mediated vesicle transport
R-DME-399710, Activation of AMPA receptors
R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-DME-5694530, Cargo concentration in the ER
R-DME-8849932, Synaptic adhesion-like molecules

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.10.1.14, the glutamate-gated ion channel (gic) family of neurotransmitter receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ionotropic receptor 25aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ir25aImported
ORF Names:CG15627Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031634, Ir25a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 562ExtracellularCuratedAdd BLAST532
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 641CytoplasmicCuratedAdd BLAST58
Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Topological domaini663 – 858ExtracellularCuratedAdd BLAST196
Transmembranei859 – 879HelicalSequence analysisAdd BLAST21
Topological domaini880 – 947CytoplasmicCuratedAdd BLAST68

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype (PubMed:21220098). Viable and fertile but their response to environmental cues such as temperature, humidity and odorants is impaired (PubMed:21220098, PubMed:26580016, PubMed:27126188, PubMed:27161501, PubMed:27656904). Response of ac4 coeloconic sensilla neurons to agonist phenylethylamine and of ac2 sensilla neurons to agonist 1,4-diaminobutane is abolished (PubMed:21220098). Response of dorsal organ cool cells to changes in temperature is abolished and consequently larvae fail to avoid cool temperatures (PubMed:27126188, PubMed:27161501, PubMed:27656904). Response of sacculus neurons to changes in humidity is also abolished and consequently larvae fail to move towards their preferred humidity (PubMed:27161501, PubMed:27656904). Failure to synchronize in constant light or constant dark to shallow temperature cycles with an amplitude of 2 degrees Celsius (PubMed:26580016). In constant light, mutants display constant activity throughout the temperature cycle in contrast to controls which show a clear activity peak in the second part of the warm period before and after a 6 hour shift of the temperature cycle (PubMed:26580016). In constant dark, mutants do not shift their evening peak during the temperature cycle in contrast to controls which advance or delay their evening activity peak during phase-advanced or phase-delayed temperature cycles (PubMed:26580016). Barely detectable levels of circadian rhythm protein tim in dorsal neurons DN1 and DN2 (PubMed:26580016). RNAi-mediated knockdown in chordonotal neurons disrupts synchronization of locomotor activity rhythms with temperature cycles (PubMed:26580016).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500718979231 – 947Ionotropic receptor 25aAdd BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi177N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi277N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi434N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi687N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi715N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi762N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9NA96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the antenna, detected in neurons of the arista and also detected in sacculus neurons which innervate the first and second chambers (at protein level) (PubMed:21220098, PubMed:19135896, PubMed:27656904). Throughout the main body of the antenna, expressed in neurons which innervate the coeloconic class of olfactory sensilla (at protein level) (PubMed:21220098, PubMed:19135896). Expressed in multiple cells of the dorsal organ including the dorsal organ cool cells (at protein level) (PubMed:27126188, PubMed:27656904). Detected in femur and retina (PubMed:26580016). Expressed in a subset of femur chordonotal neurons and antennal Johnston's Organ neurons (PubMed:26580016).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031634, Expressed in antenna and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9NA96, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nocte.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304756

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1052, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174434

Identification of Orthologs from Complete Genome Data

More...
OMAi
YFERMAN

Database of Orthologous Groups

More...
OrthoDBi
188544at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR028082, Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00177, NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9NA96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILMNPKTSK ILWLLGFLSL LSSFSLEIAA QTTQNINVLF INEVDNEPAA
60 70 80 90 100
KAVEVVLTYL KKNIRYGLSV QLDSIEANKS DAKVLLEAIC NKYATSIEKK
110 120 130 140 150
QTPHLILDTT KSGIASETVK SFTQALGLPT ISASYGQQGD LRQWRDLDEA
160 170 180 190 200
KQKYLLQVMP PADIIPEAIR SIVIHMNITN AAILYDDSFV MDHKYKSLLQ
210 220 230 240 250
NIQTRHVITA IAKDGKRERE EQIEKLRNLD INNFFILGTL QSIRMVLESV
260 270 280 290 300
KPAYFERNFA WHAITQNEGE ISSQRDNATI MFMKPMAYTQ YRDRLGLLRT
310 320 330 340 350
TYNLNEEPQL SSAFYFDLAL RSFLTIKEML QSGAWPKDME YLNCDDFQGG
360 370 380 390 400
NTPQRNLDLR DYFTKITEPT SYGTFDLVTQ STQPFNGHSF MKFEMDINVL
410 420 430 440 450
QIRGGSSVNS KSIGKWISGL NSELIVKDEE QMKNLTADTV YRIFTVVQAP
460 470 480 490 500
FIMRDETAPK GYKGYCIDLI NEIAAIVHFD YTIQEVEDGK FGNMDENGQW
510 520 530 540 550
NGIVKKLMDK QADIGLGSMS VMAEREIVID FTVPYYDLVG ITIMMQRPSS
560 570 580 590 600
PSSLFKFLTV LETNVWLCIL AAYFFTSFLM WIFDRWSPYS YQNNREKYKD
610 620 630 640 650
DEEKREFNLK ECLWFCMTSL TPQGGGEAPK NLSGRLVAAT WWLFGFIIIA
660 670 680 690 700
SYTANLAAFL TVSRLDTPVE SLDDLAKQYK ILYAPLNGSS AMTYFERMSN
710 720 730 740 750
IEQMFYEIWK DLSLNDSLTA VERSKLAVWD YPVSDKYTKM WQAMQEAKLP
760 770 780 790 800
ATLDEAVARV RNSTAATGFA FLGDATDIRY LQLTNCDLQV VGEEFSRKPY
810 820 830 840 850
AIAVQQGSHL KDQFNNAILT LLNKRQLEKL KEKWWKNDEA LAKCDKPEDQ
860 870 880 890 900
SDGISIQNIG GVFIVIFVGI GMACITLVFE YWWYRYRKNP RIIDVAEANA
910 920 930 940
ERSNAADHPG KLVDGVILGH SGEKFEKSKA ALRPRFNQYP ATFKPRF
Length:947
Mass (Da):108,122
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8834A2127F6FE77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VR32Q9VR32_DROME
Ionotropic receptor 25a, isoform B
Ir25a CT35778, Dmel\CG15627, DmelIR25a, IR25a, ir25a
934Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PC56M9PC56_DROME
Ionotropic receptor 25a, isoform D
Ir25a CT35778, Dmel\CG15627, DmelIR25a, IR25a, ir25a
929Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ600588 mRNA Translation: ADU79032.1
AE014134 Genomic DNA Translation: AGB92585.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260049.1, NM_001273120.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332480; FBpp0304756; FBgn0031634

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33683

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG15627

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ600588 mRNA Translation: ADU79032.1
AE014134 Genomic DNA Translation: AGB92585.1
RefSeqiNP_001260049.1, NM_001273120.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0304756

Protein family/group databases

TCDBi1.A.10.1.14, the glutamate-gated ion channel (gic) family of neurotransmitter receptors

Proteomic databases

PaxDbiE9NA96

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
33683

Genome annotation databases

EnsemblMetazoaiFBtr0332480; FBpp0304756; FBgn0031634
GeneIDi33683
KEGGidme:Dmel_CG15627

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33683
FlyBaseiFBgn0031634, Ir25a

Phylogenomic databases

eggNOGiKOG1052, Eukaryota
GeneTreeiENSGT00940000174434
OMAiYFERMAN
OrthoDBi188544at2759

Enzyme and pathway databases

ReactomeiR-DME-204005, COPII-mediated vesicle transport
R-DME-399710, Activation of AMPA receptors
R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-DME-5694530, Cargo concentration in the ER
R-DME-8849932, Synaptic adhesion-like molecules

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33683, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33683

Protein Ontology

More...
PROi
PR:E9NA96

Gene expression databases

BgeeiFBgn0031634, Expressed in antenna and 20 other tissues
ExpressionAtlasiE9NA96, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR028082, Peripla_BP_I
PfamiView protein in Pfam
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177, NMDARECEPTOR
SMARTiView protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIR25A_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9NA96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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