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UniProtKB - E9KL44 (E9KL44_HUMAN)
Protein
Enoyl-CoA hydratase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- This reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the backwardARBA annotation direction.
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
GO - Molecular functioni
- acetyl-CoA C-acyltransferase activity Source: Ensembl
- enoyl-CoA hydratase activity Source: UniProtKB-EC
- fatty-acyl-CoA binding Source: Ensembl
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity Source: Ensembl
- long-chain-enoyl-CoA hydratase activity Source: Ensembl
- NAD+ binding Source: InterPro
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- fatty acid beta-oxidation Source: UniProtKB-UniPathway
- response to insulin Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
Keywordsi
Molecular function | LyaseARBA annotation |
Biological process | Fatty acid metabolismARBA annotation, Lipid metabolism |
Ligand | NADARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00659 |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000084754 |
Subcellular locationi
Mitochondrion
- mitochondrial fatty acid beta-oxidation multienzyme complex Source: Ensembl
- mitochondrion Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000084754, Expressed in gastrocnemius and 253 other tissues |
ExpressionAtlasi | E9KL44, baseline and differential |
Genevisiblei | E9KL44, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 364 – 541 | 3HCDH_NInterPro annotationAdd BLAST | 178 | |
Domaini | 544 – 639 | 3HCDHInterPro annotationAdd BLAST | 96 | |
Domaini | 676 – 754 | 3HCDHInterPro annotationAdd BLAST | 79 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 113 – 133 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_009834_16_1_1 |
OMAi | PFRYMDT |
OrthoDBi | 219667at2759 |
PhylomeDBi | E9KL44 |
Family and domain databases
InterProi | View protein in InterPro IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR029045, ClpP/crotonase-like_dom_sf IPR018376, Enoyl-CoA_hyd/isom_CS IPR001753, Enoyl-CoA_hydra/iso IPR012803, Fa_ox_alpha_mit IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 2 hits PF02737, 3HCDH_N, 1 hit PF00378, ECH_1, 1 hit |
SUPFAMi | SSF48179, SSF48179, 2 hits SSF51735, SSF51735, 1 hit SSF52096, SSF52096, 1 hit |
TIGRFAMsi | TIGR02441, fa_ox_alpha_mit, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit PS00166, ENOYL_COA_HYDRATASE, 1 hit |
i Sequence
Sequence statusi: Complete.
E9KL44-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA
60 70 80 90 100
VVRINSPNSK VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA
110 120 130 140 150
GADINMLAAC KTLQEVTQLS QEAQRIVEKL EKSTKPIVAA INGSCLGGGL
160 170 180 190 200
EVAISCQYRI ATKDRKTVLG TPEVLLGALP GAGGTQRLPK MVGVPAALDM
210 220 230 240 250
MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL EEVAITFAKG
260 270 280 290 300
LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA
310 320 330 340 350
PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK
360 370 380 390 400
KNKFGAPQKD VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG
410 420 430 440 450
QQQVFKGLND KVKKKALTSF ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE
460 470 480 490 500
DLSLKHRVLK EVEAVIPDHC IFASNTSALP ISEIAAVSKR PEKVIGMHYF
510 520 530 540 550
SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK DGPGFYTTRC
560 570 580 590 600
LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA
610 620 630 640 650
EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS
660 670 680 690 700
DMDSILASLK LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG
710 720 730 740 750
DIGAVFGLGF PPCLGGPFRF VDLYGAQKIV DRLKKYEAAY GKQFTPCQLL
760
ADHANSPNKK FYQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU727642 mRNA Translation: ADU87643.1 |
RefSeqi | NP_000173.2, NM_000182.4 |
Genome annotation databases
GeneIDi | 3030 |
KEGGi | hsa:3030 |
MANE-Selecti | ENST00000380649.8; ENSP00000370023.3; NM_000182.5; NP_000173.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU727642 mRNA Translation: ADU87643.1 |
RefSeqi | NP_000173.2, NM_000182.4 |
3D structure databases
SMRi | E9KL44 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | E9KL44, 2 interactors |
MINTi | E9KL44 |
Proteomic databases
PRIDEi | E9KL44 |
Protocols and materials databases
Antibodypediai | 3074, 215 antibodies from 32 providers |
DNASUi | 3030 |
Genome annotation databases
GeneIDi | 3030 |
KEGGi | hsa:3030 |
MANE-Selecti | ENST00000380649.8; ENSP00000370023.3; NM_000182.5; NP_000173.2 |
Organism-specific databases
CTDi | 3030 |
VEuPathDBi | HostDB:ENSG00000084754 |
Phylogenomic databases
HOGENOMi | CLU_009834_16_1_1 |
OMAi | PFRYMDT |
OrthoDBi | 219667at2759 |
PhylomeDBi | E9KL44 |
Enzyme and pathway databases
UniPathwayi | UPA00659 |
Miscellaneous databases
BioGRID-ORCSi | 3030, 14 hits in 1082 CRISPR screens |
GenomeRNAii | 3030 |
Gene expression databases
Bgeei | ENSG00000084754, Expressed in gastrocnemius and 253 other tissues |
ExpressionAtlasi | E9KL44, baseline and differential |
Genevisiblei | E9KL44, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006180, 3-OHacyl-CoA_DH_CS IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR029045, ClpP/crotonase-like_dom_sf IPR018376, Enoyl-CoA_hyd/isom_CS IPR001753, Enoyl-CoA_hydra/iso IPR012803, Fa_ox_alpha_mit IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 2 hits PF02737, 3HCDH_N, 1 hit PF00378, ECH_1, 1 hit |
SUPFAMi | SSF48179, SSF48179, 2 hits SSF51735, SSF51735, 1 hit SSF52096, SSF52096, 1 hit |
TIGRFAMsi | TIGR02441, fa_ox_alpha_mit, 1 hit |
PROSITEi | View protein in PROSITE PS00067, 3HCDH, 1 hit PS00166, ENOYL_COA_HYDRATASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9KL44_HUMAN | |
Accessioni | E9KL44Primary (citable) accession number: E9KL44 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |