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UniProtKB - E9KL35 (E9KL35_HUMAN)
Protein
Submitted name:
Epididymis tissue sperm binding protein Li 3a
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ion channel inhibitor activity Source: Ensembl
- ribosome binding Source: InterPro
GO - Biological processi
- negative regulation of hydrogen peroxide-induced neuron death Source: Ensembl
- pigmentation Source: Ensembl
- translation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Ribonucleoprotein, Ribosomal proteinARBA annotation |
Biological process | GastrulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Epididymis tissue sperm binding protein Li 3aImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000204628 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- dendrite Source: Ensembl
- neuronal cell body Source: Ensembl
- small ribosomal subunit Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000204628, Expressed in female gonad and 258 other tissues |
ExpressionAtlasi | E9KL35, baseline and differential |
Genevisiblei | E9KL35, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 53 | WDPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 59 – 100 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 101 – 133 | WDPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 144 – 187 | WDPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 188 – 229 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 287 – 317 | WDPROSITE-ProRule annotationAdd BLAST | 31 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OMAi | CKAMLWD |
OrthoDBi | 805365at2759 |
PhylomeDBi | E9KL35 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR045223, Asc1/RACK1 IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR19868, PTHR19868, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 6 hits |
i Sequence
Sequence statusi: Complete.
E9KL35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET
60 70 80 90 100
NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR
110 120 130 140 150
FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW
160 170 180 190 200
VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA NCKLKTNHIG HTGYLNTVTV
210 220 230 240 250
SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC FSPNRYWLCA
260 270 280 290 300
ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
310
GYTDNLVRVW QVTIGTR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU727632 mRNA Translation: ADU87634.1 |
RefSeqi | NP_006089.1, NM_006098.4 |
Genome annotation databases
GeneIDi | 10399 |
KEGGi | hsa:10399 |
MANE-Selecti | ENST00000512805.6; ENSP00000426909.1; NM_006098.5; NP_006089.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU727632 mRNA Translation: ADU87634.1 |
RefSeqi | NP_006089.1, NM_006098.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7NWH | electron microscopy | 4.10 | gg | 1-314 | [»] | |
SMRi | E9KL35 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | E9KL35, 4 interactors |
MINTi | E9KL35 |
Proteomic databases
PRIDEi | E9KL35 |
Protocols and materials databases
Antibodypediai | 3802, 456 antibodies from 44 providers |
DNASUi | 10399 |
Genome annotation databases
GeneIDi | 10399 |
KEGGi | hsa:10399 |
MANE-Selecti | ENST00000512805.6; ENSP00000426909.1; NM_006098.5; NP_006089.1 |
Organism-specific databases
CTDi | 10399 |
VEuPathDBi | HostDB:ENSG00000204628 |
Phylogenomic databases
OMAi | CKAMLWD |
OrthoDBi | 805365at2759 |
PhylomeDBi | E9KL35 |
Miscellaneous databases
BioGRID-ORCSi | 10399, 819 hits in 1077 CRISPR screens |
GenomeRNAii | 10399 |
Gene expression databases
Bgeei | ENSG00000204628, Expressed in female gonad and 258 other tissues |
ExpressionAtlasi | E9KL35, baseline and differential |
Genevisiblei | E9KL35, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR045223, Asc1/RACK1 IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR19868, PTHR19868, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | E9KL35_HUMAN | |
Accessioni | E9KL35Primary (citable) accession number: E9KL35 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |