UniProtKB - E9KL26 (E9KL26_HUMAN)
Protein
Submitted name:
Epididymis tissue protein Li 173
Gene
SERPING1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: InterPro
GO - Biological processi
- negative regulation of complement activation Source: InterPro
- regulation of blood coagulation Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Epididymis tissue protein Li 173ImportedSubmitted name: Serpin peptidase inhibitor clade G member 1 isoform 1Imported |
Gene namesi | Name:SERPING1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000149131.15 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014303310 | 23 – 500 | Sequence analysisAdd BLAST | 478 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149131, Expressed in right lobe of liver and 242 other tissues |
ExpressionAtlasi | E9KL26, baseline and differential |
Genevisiblei | E9KL26, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 151 – 498 | SERPINInterPro annotationAdd BLAST | 348 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 43 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 65 – 118 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 36 | PolarSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the serpin family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
OrthoDBi | 1124079at2759 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR015553, C1-inh IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF159, PTHR11461:SF159, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
E9KL26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI
60 70 80 90 100
SKMLFVEPIL EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI
110 120 130 140 150
QPTQPTTQLP TDSPTQPTTG SFCPGPVTLC SDLESHSTEA VLGDALVDFS
160 170 180 190 200
LKLYHAFSAM KKVETNMAFS PFSIASLLTQ VLLGAGENTK TNLESILSYP
210 220 230 240 250
KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS RTLYSSSPRV
260 270 280 290 300
LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK
310 320 330 340 350
TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS
360 370 380 390 400
HNLSLVILVP QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR
410 420 430 440 450
IKVTTSQDML SIMEKLEFFD FSYDLNLCGL TEDPDLQVSA MQHQTVLELT
460 470 480 490 500
ETGVEAAAAS AISVARTLLV FEVQQPFLFV LWDQQHKFPV FMGRVYDPRA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU727623 mRNA Translation: ADU87625.1 KU177948 mRNA Translation: ALQ33406.1 |
RefSeqi | NP_000053.2, NM_000062.2 NP_001027466.1, NM_001032295.1 |
Genome annotation databases
GeneIDi | 710 |
KEGGi | hsa:710 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU727623 mRNA Translation: ADU87625.1 KU177948 mRNA Translation: ALQ33406.1 |
RefSeqi | NP_000053.2, NM_000062.2 NP_001027466.1, NM_001032295.1 |
3D structure databases
SMRi | E9KL26 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 14214, 543 antibodies |
DNASUi | 710 |
Genome annotation databases
GeneIDi | 710 |
KEGGi | hsa:710 |
Organism-specific databases
CTDi | 710 |
VEuPathDBi | HostDB:ENSG00000149131.15 |
Phylogenomic databases
OrthoDBi | 1124079at2759 |
Miscellaneous databases
BioGRID-ORCSi | 710, 5 hits in 876 CRISPR screens |
ChiTaRSi | SERPING1, human |
GenomeRNAii | 710 |
Gene expression databases
Bgeei | ENSG00000149131, Expressed in right lobe of liver and 242 other tissues |
ExpressionAtlasi | E9KL26, baseline and differential |
Genevisiblei | E9KL26, HS |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR015553, C1-inh IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF159, PTHR11461:SF159, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9KL26_HUMAN | |
Accessioni | E9KL26Primary (citable) accession number: E9KL26 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |