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Entry version 41 (12 Aug 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

DAPPUDRAFT_320145

Organism
Daphnia pulex (Water flea)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DAPPUDRAFT_320145Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDaphnia pulex (Water flea)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaDiplostracaCladoceraAnomopodaDaphniidaeDaphnia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000305 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi674 ↔ 692PROSITE-ProRule annotation
Disulfide bondi686 ↔ 701PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini450 – 585A2M_N_2InterPro annotationAdd BLAST136
Domaini1399 – 1490A2M_recepInterPro annotationAdd BLAST92

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001634_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9GNZ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
LISANIC

Database of Orthologous Groups

More...
OrthoDBi
20179at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9GNZ6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.690, 1 hit
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR001599, Macroglobln_a2
IPR002890, MG2
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50068, LDLRA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9GNZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVLPDAEGL IVKALITKDG GQHIASAIET IDSGVSHNLL LKIPGSLTDG
60 70 80 90 100
QYQLKLDGYD LLQPQKSVFS KRGHLEFHPD FLSILVQTNR KIYKNEMKVR
110 120 130 140 150
FRAIITQLVN LKPYSDPVTV YILNPEGFVM RRWPSRYPTT GVITLLYQLP
160 170 180 190 200
TFPSEGKWTI RVEAMSQIHD HHIIVERFYY RFFDVIPSAP AYVLDSDESY
210 220 230 240 250
TAAVTTSFHP GRVASGNLTL QVYARPVNSS LADFRFVRQD FHQWTYDFTY
260 270 280 290 300
NVQLEEVKRS VGVSSLTGWV IRVAMTLYHH FEGESRNGFI ETRIIRAQLK
310 320 330 340 350
FRFGGSKTAV FKPGMPYEGH VYLMYDDDEA VSPEKLAGAT LTIRPVATTS
360 370 380 390 400
NGQLKTLPEI VVPRQGEYHR SSDDDHLNYY GNKYDVWMDR QMEDAEYKTF
410 420 430 440 450
RQFGIHHFRF TVPKDATSLK ITAYYKDDEG DQVSVDQQAV AFYSLGNFFV
460 470 480 490 500
HVSTSTDEGL LGHFATIHLR SNFAFQDYSY VISSKGLVVH GATETLAHAT
510 520 530 540 550
KSLTFSVPVS TDMAPTFKLV AMMVSPLGDL VADSVTIPVQ SINRYKTNLT
560 570 580 590 600
MVQTKDHSKL TVQVVTRTLP GAFTGVSLIR SANYMFQADN EITYSRMIRA
610 620 630 640 650
LYQLEPFSRS VSGITWTDRE GSKADKSQYF KSANPGADTK RTFNLAGLLV
660 670 680 690 700
FTDARISQYP DTANCNKANG YEPCMAVGCF HKDQRCDGKS DCTDGSDEDD
710 720 730 740 750
CPLTKDDRMD FRMFRRNRFH DFYDWLDGDW AWFDIPVTDD GFDFNDRSVA
760 770 780 790 800
LTNEVWFLNA FTFHRELGFA VVDDVVEYEG SLPFYVSVES PSFIRRGETV
810 820 830 840 850
GIRLLFINNL QVDTMGLIIL EASDDYCFVE TEAHGEVAHY HPSLVCAEKH
860 870 880 890 900
HVVTVKGGTT TEVFMPISPR IEQGSITVKI QVLSHIFEQN LEIGLEVLPE
910 920 930 940 950
GATISRHTSL LLDLKNRAHL LRFLDIPVEE SPIIPYSKFR RYVFGSPRAS
960 970 980 990 1000
ITLCGDVFGP VFPSTPITTD SMLSRSLRGT EANLYNLATT SWSLHYLRLT
1010 1020 1030 1040 1050
NQLVSDVLYS GLNDMNVQMA ELMRLYHHDG SFRAHTNSNP SVWVTAWVIR
1060 1070 1080 1090 1100
ILGQSQFQDW ENHYYVDQQL LTNSVKWILQ FQRRDGSFGE TENYISPLDR
1110 1120 1130 1140 1150
RLLPRYNSTF KGGHTAHVLL SLCATSESLD GAVKVATASA KVRAVRYLER
1160 1170 1180 1190 1200
ILDILTDQYE LAIVTYALQI TSSPAQEAAF GRLHILRREE EGMVYWSREP
1210 1220 1230 1240 1250
VPSNKILYEN QRPFLQPRLP MHQDAVAVEA TSYALLVYLA RDGIGDLQER
1260 1270 1280 1290 1300
VVSWLNTMRM VDGGFVSIYD SIVAMEALTE YAYRARLRDI TDMSVVVEAS
1310 1320 1330 1340 1350
ASPDATELMK INSDTLATVH RMDIPNVWGH VNVIGRGAGQ AVLQLKVQYG
1360 1370 1380 1390 1400
IDWEDLRDTP KRRYFDLYVE ETYSHFRNKS HITVDACVKW LAMDEAPVSG
1410 1420 1430 1440 1450
STTLEVELPS GYRIVQSDAD QVLIHKNYTF LRDVFVSDEK IVWTFDKVGP
1460 1470 1480 1490 1500
ERLCFNYLIR RWFPVANGTM YRSAIVYESH SPEHFEMQVF NATPLYVLDI
1510 1520 1530 1540
CEVCGSYQCP YCPYFSAAPV VVSFNPIIVF CSLLISANIC LNWSTS
Length:1,546
Mass (Da):175,605
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A2C6786FBB807C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL732555 Genomic DNA Translation: EFX78839.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EFX78839; EFX78839; DAPPUDRAFT_320145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dpx:DAPPUDRAFT_320145

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL732555 Genomic DNA Translation: EFX78839.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiEFX78839; EFX78839; DAPPUDRAFT_320145
KEGGidpx:DAPPUDRAFT_320145

Phylogenomic databases

eggNOGiKOG1366, Eukaryota
HOGENOMiCLU_001634_5_1_1
InParanoidiE9GNZ6
OMAiLISANIC
OrthoDBi20179at2759
PhylomeDBiE9GNZ6

Family and domain databases

CDDicd00112, LDLa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.690, 1 hit
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR001599, Macroglobln_a2
IPR002890, MG2
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50068, LDLRA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9GNZ6_DAPPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9GNZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: August 12, 2020
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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