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Entry version 56 (02 Jun 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Calcium channel protein, putative

Gene

LDBPK_340500

Organism
Leishmania donovani (strain BPK282A1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.11.33, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium channel protein, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LDBPK_340500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania donovani (strain BPK282A1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri981087 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008980 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 34

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
TriTrypDB:LdBPK_340500.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei143 – 159HelicalSequence analysisAdd BLAST17
Transmembranei179 – 200HelicalSequence analysisAdd BLAST22
Transmembranei274 – 297HelicalSequence analysisAdd BLAST24
Transmembranei389 – 412HelicalSequence analysisAdd BLAST24
Transmembranei890 – 908HelicalSequence analysisAdd BLAST19
Transmembranei920 – 941HelicalSequence analysisAdd BLAST22
Transmembranei948 – 970HelicalSequence analysisAdd BLAST23
Transmembranei1010 – 1032HelicalSequence analysisAdd BLAST23
Transmembranei1089 – 1110HelicalSequence analysisAdd BLAST22
Transmembranei1590 – 1612HelicalSequence analysisAdd BLAST23
Transmembranei1633 – 1652HelicalSequence analysisAdd BLAST20
Transmembranei1664 – 1684HelicalSequence analysisAdd BLAST21
Transmembranei1729 – 1752HelicalSequence analysisAdd BLAST24
Transmembranei1826 – 1854HelicalSequence analysisAdd BLAST29
Transmembranei1909 – 1930HelicalSequence analysisAdd BLAST22
Transmembranei1942 – 1960HelicalSequence analysisAdd BLAST19
Transmembranei1972 – 1991HelicalSequence analysisAdd BLAST20
Transmembranei2011 – 2032HelicalSequence analysisAdd BLAST22
Transmembranei2044 – 2064HelicalSequence analysisAdd BLAST21
Transmembranei2126 – 2148HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini145 – 418Ion_transInterPro annotationAdd BLAST274
Domaini889 – 1121Ion_transInterPro annotationAdd BLAST233
Domaini1590 – 1851Ion_transInterPro annotationAdd BLAST262
Domaini1907 – 2152Ion_transInterPro annotationAdd BLAST246

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni470 – 503DisorderedSequence analysisAdd BLAST34
Regioni546 – 584DisorderedSequence analysisAdd BLAST39
Regioni656 – 727DisorderedSequence analysisAdd BLAST72
Regioni827 – 857DisorderedSequence analysisAdd BLAST31
Regioni1282 – 1341DisorderedSequence analysisAdd BLAST60
Regioni2432 – 2471DisorderedSequence analysisAdd BLAST40
Regioni2491 – 2523DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili512 – 532Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi566 – 583Polar residuesSequence analysisAdd BLAST18
Compositional biasi672 – 691Polar residuesSequence analysisAdd BLAST20
Compositional biasi711 – 727Polar residuesSequence analysisAdd BLAST17
Compositional biasi827 – 846Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2432 – 2454Basic and acidic residuesSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQAWSCG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9BQK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIPLARTQP IEKFFVEYNS AAAEREDDGQ PRDDNEVLLM QFAEYTDDDS
60 70 80 90 100
FFSSSDTVIE CDPQRLRSDP LRRRAVVSVH NTLQLRALTN GRVPEDMVWN
110 120 130 140 150
NVTRTSWLYQ IHNRAIALQH SSFFIFPARW TPRVMVYNVM HHWLMEMFIF
160 170 180 190 200
LMILGYAIFQ ATWSRYTAPP GGMHKPDHII WADVFYTCLL GFEIIARLFA
210 220 230 240 250
SGGILHKRAF FRSPWRWLDT AVLVLSIMEC TWWQDLWNFT AWRLIRTIKC
260 270 280 290 300
LTYVPAPVRM KLLAKSLLRS TNRLIYVTIF LTYFIFFFGL LGLQLFVGTL
310 320 330 340 350
HSRCVNTLTG AVTSQVCRSV ATGQYGFYWG HHCGVFYTCQ ADAFPNPHYD
360 370 380 390 400
FRSFDDIGHA MLSVFQIMTF QGWSELLQET NDGLAMMAFL YYFFTILVCA
410 420 430 440 450
WIVPSLYLGV FLEKMDKTSR LFVLKQLDFF DHMLTEQRQR MSSMVRLNDY
460 470 480 490 500
VERDENGFVS HYPAYTLQQQ DDKRLTSDDS TSGSTDDKNM NAHRIKSHHR
510 520 530 540 550
AIQATKWTDE QRIQLQLALT RQRDVAEEAE RKRQLQQAAL GDLIVEEGGA
560 570 580 590 600
GKRQGTGRRG ASPAGAASGS ATQTETSPQP TKERSEFALG GRVGAVQHHP
610 620 630 640 650
AAYAIGDSHQ SDLPFAVRQE VQAEQLRFLD PYTNGASAAK NDMYNSAAAL
660 670 680 690 700
RTSIDQSRTA VPGGGAESAT VLHSRPVSNA RPSTRAPSAP STSVMVAREA
710 720 730 740 750
AGVVPHRRST SVRGGTLSRA SSMNGRGSLS RLHASMTQVP QAPTQQEQTA
760 770 780 790 800
YVINDPEGGD FDYAKTLGQK INIIRNIAHM FTEGYPRIIS QYLWEHRMMQ
810 820 830 840 850
HRYGLTPLSY TNKYEEEALR RLRQRRAQER REEREELRRS GMGHLIDDDE
860 870 880 890 900
DEDDDSLAEK PWMRQEGLVP GSMSPIRMAR NIRENAPITV FNYIMYSFII
910 920 930 940 950
ANAVFNASRF DTMPDYWETG TFIAGVCFSV LFMLELLIRL LALGPGPFFT
960 970 980 990 1000
DIVILIEATF MVTSLFQLGY SRANTTSLFN WVRFLRLFRV IPCRPLRRVS
1010 1020 1030 1040 1050
RVLIHGFPDM VYALVFFTLY MFMWLLLGMS FFGSRIGWID YNTSDYTTRG
1060 1070 1080 1090 1100
TFETFSHAAY AVAQAFSVNR DQWLYLSWSG MRVRGSYTVM YFIATVCVAF
1110 1120 1130 1140 1150
IFRFFFIAVM TCAWQAQQEK EDYYFMSGSS HGRRGRRSRF ARLPFFDFSV
1160 1170 1180 1190 1200
WRSFKHIHGG FDRRDVAPDE IYFLNEDMAR QLRLVEAKDR YYREHYGQEK
1210 1220 1230 1240 1250
SEWSDMGEGS QVGGSDMYGP DGALVNGPQY VNIGGRLYRQ PSLPATEMGF
1260 1270 1280 1290 1300
SVVGTPQQRG QLRFARHHRA VPATTYAAAQ LQRPAGAHDA LPDEVVGSRS
1310 1320 1330 1340 1350
LSRHSRRSMA NPLLADRHSL SPAHQGTSVG GPSVARVSDS LAEERAKNTN
1360 1370 1380 1390 1400
ISLVPRLTKL GNARALVVAG DDEATADYST PEGGVSDEDF EHLLLPGPRL
1410 1420 1430 1440 1450
RYKSTMDEGR RVFETCLDCN THMQMPLRAP PGVAQRTAEE LHAEHCHMAA
1460 1470 1480 1490 1500
VRSSQQLVLN ALIGYTRMQA DHEVTPTKRM VEIVLGQAWS CGMLLFDTIE
1510 1520 1530 1540 1550
NLSCMDLPEQ ERTWDRMLEA LEMQQWLLGL HVGEEQVGRA TLAYILANQQ
1560 1570 1580 1590 1600
RQEAQVREKS YKNTWEDRVF FVLSPSNPVR RAVSAVVGSM WFEIAVLCVV
1610 1620 1630 1640 1650
YAASICLAVY APDEGNRDFG GSYNSAKYKV LHILDDIFSI IFAVEMVLKW
1660 1670 1680 1690 1700
ISMGVVLPVG RAYFWHRWNI FDFFIVIISL VSWGRPDIFL RYLKVMRCFR
1710 1720 1730 1740 1750
ILGPLRYWKW GSSSMSHVAR AIWDSIPTLA NVCLLMLMNY IVWAIIFVSL
1760 1770 1780 1790 1800
FMDKFNYCSN ASIVNGTQCV EEGYTWAPTQ RNFRNFYESL LTTFEISTGA
1810 1820 1830 1840 1850
EWIDVIYSAV DSRSALLSPL RNQRPYLGLV FIAYYYVSHF IFFTLFISAV
1860 1870 1880 1890 1900
IYCYMLAKSA TEDATGTTIE HQVWLRMQGM IFRLKPKVQL LPLDTRVSRL
1910 1920 1930 1940 1950
VHFLISNRWF EAFMGLILVF NMLTMSLEWY QMSSTQKTTL DAFQYIWVVI
1960 1970 1980 1990 2000
FTLEVVLRFV AHGLRFFTRR AYCWDLLIVV LSYIQIGLST TATNRVPFNV
2010 2020 2030 2040 2050
NVLRMLRVGR VLHLVHLVLP FSTHLTLFHE VLKASVPGLI SVTFVYMIAV
2060 2070 2080 2090 2100
YVFAILGLHF LGYIVPFGGY IDDKYNNFGT FVNALIMVFR LSTLQNWATM
2110 2120 2130 2140 2150
LRGSLDRGYY CARASKRCGP TDWAPVYYIP IVICFFLLLS TLYMAVVLDK
2160 2170 2180 2190 2200
YVAAVRIYSA VTRLDELRRF CRLWSKRDPN GTMWLPSAVL PELLEELRLP
2210 2220 2230 2240 2250
LGVSDRRNRV EVMQLLREYN IPDHNGRVYY YEVLLPLARR VMAIAFLEAA
2260 2270 2280 2290 2300
DAHTAGSQAP RDIAWHLSER SLGALPASYG TVRPSSVTVA EHYAAALLQA
2310 2320 2330 2340 2350
AFRRDRAMRD YYIAKSELWR RGRAVCVERG LPYDNFGFGK TPLAGPDPRE
2360 2370 2380 2390 2400
EGMRRGFNIP KDATLANSAG GRVYADPVAA RIAAMREAMG SHKRATDQEP
2410 2420 2430 2440 2450
PTLLPAVYRS AIYPEEKRFG PNAPGAIRRH ERRDEKLERK RAQEEYERQM
2460 2470 2480 2490 2500
YERSTRGCPA RTAGEQKDNE TVTAEGAGDV DVGLAYSKGT MEPHPAARGN
2510 2520 2530 2540 2550
QYNLDPMDVN YQPPLGTSPE ELRQEKVDRR LNAAAAAATA SATLGGISPS

TTPEQY
Length:2,556
Mass (Da):291,274
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC979D555E075992E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR799621 Genomic DNA Translation: CBZ37533.1

NCBI Reference Sequences

More...
RefSeqi
XP_003864215.1, XM_003864167.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CBZ37533; CBZ37533; LDBPK_340500

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LdBPK_340500.1.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13392624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ldo:LDBPK_340500

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799621 Genomic DNA Translation: CBZ37533.1
RefSeqiXP_003864215.1, XM_003864167.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.1.11.33, the voltage-gated ion channel (vic) superfamily

Genome annotation databases

EnsemblProtistsiCBZ37533; CBZ37533; LDBPK_340500
GeneDBiLdBPK_340500.1.1:pep
GeneIDi13392624
KEGGildo:LDBPK_340500

Organism-specific databases

VEuPathDBiTriTrypDB:LdBPK_340500.1

Phylogenomic databases

OMAiGQAWSCG

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9BQK4_LEIDB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9BQK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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