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UniProtKB - E9BGX5 (E9BGX5_LEIDB)

Entry version 44 (31 Jul 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Pre-mRNA splicing factor, putative

Gene

LDBPK_241120

Organism
Leishmania donovani (strain BPK282A1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pre-mRNA splicing factor, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LDBPK_241120Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania donovani (strain BPK282A1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri981087 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008980 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		TriTrypDB:LdBPK_241120.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini386 – 550Helicase ATP-bindingInterPro annotationAdd BLAST165
Domaini575 – 754Helicase C-terminalInterPro annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni81 – 111DisorderedSequence analysisAdd BLAST31
Regioni249 – 280DisorderedSequence analysisAdd BLAST32
Regioni306 – 363DisorderedSequence analysisAdd BLAST58
Regioni1036 – 1086DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15PolyampholyteSequence analysisAdd BLAST15
Compositional biasi333 – 363PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1036 – 1065PolarSequence analysisAdd BLAST30

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000175261

Identification of Orthologs from Complete Genome Data

More...OMAi		DEMGCAL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9BGX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAVPADHGI KRPREANSPG HTPPFVSAND VAASLQEQAQ RFISQLEMGE 
        60         70         80         90        100
VLEHDRDTTE AVMTGTDESA QWAYGSEYYL RHDGEDDKEH PSCSHTAGST 
       110        120        130        140        150
AAAAAAQESA SDAQADKARK VVVSLTVAPP SFFTSGNDFE TSVLSRRSAA 
       160        170        180        190        200
AANKDDDDDG GDLDRRGGFV ASRFLHEALR TSDVDIIVPV VSHSCSLAVS 
       210        220        230        240        250
ASKGSQTLAE LKRLMDRERT NRDVMDTSKS SLTQLLQKDT YGRMVNGEEK 
       260        270        280        290        300
GVAGVGSGSA PGHAHSGSVS SFTDDRRNDN GEEEEAKYLM RQLRLEQERL 
       310        320        330        340        350
ADMARLRGAS DASSTAPPPA AGGANSQWGS SQESRRQRKD EQLARIEGRK 
       360        370        380        390        400
AQMETLADDA DEVERRDAMR RQRESLPIHH CKDELLRYIG ESAVTVVVGE 
       410        420        430        440        450
TGSGKTTQLV QYLYQRGYAR HGKIIGCTQP RRLAAIGVAR RVSDEMGCAL 
       460        470        480        490        500
GTTVGYSIHL DDTTTADTRV KFMTDGVLLR ETVNDPSLDK YSVVMLDEAH 
       510        520        530        540        550
ERSVDTDVLM GVLKLALRRR GDLKLIVTSA TMDVRKFSAF FGNAPCYEIP 
       560        570        580        590        600
GQTFPVKIHY SPTPVADYVA EAVFRVCQLH LQMPLEAKHD ILVFMTGRED 
       610        620        630        640        650
VYGTCELIRR RLAELSPQHL STLLIMSCLS EAASAWSTEI GVLDATPAGL 
       660        670        680        690        700
RKVVVATNVA ETSLTIDGVR YVVDCGFMKT NVYRPSIGMN TLQRYPTSQA 
       710        720        730        740        750
QANQRKGRAG RTTEGTCYRL YTEEQYAEEM LPNSVPEIQR SSVDSVVLLL 
       760        770        780        790        800
KSIGVHRLCD FDFMDAPPAA NVRSSMFHLW VLGFLDDAGA ITEQGQQALE 
       810        820        830        840        850
FPMSPVLAKL LLESAKMGCA LEMARIVAMI SADPKNLFEL PKGREKVAQQ 
       860        870        880        890        900
HHSRFYSNDS DHLTLLHVFT QYLDHGRSRQ WAQDHFLHSP TLARANDVFA 
       910        920        930        940        950
QLIEKLRKVH LPIQSCGHAE TDKVRHCLAK AFALQAARRS DRRWTEYRPL 
       960        970        980        990       1000
LNAGVACEVH PASAVHARSE MPPYIIYNDL LLTHKEYLVM VTAVEPEWLV 
      1010       1020       1030       1040       1050
ESSRGIYEMR HGVTSSSTTT APSSFAVAVT TTPTPFTASR ASRASMSSSP 
      1060       1070       1080 
TAPSASGSST KVCAETKAPT KKPAFGMLSS KRRPNI
Length:1,086
Mass (Da):119,263
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D2874275FFEB956
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FR799611 Genomic DNA Translation: CBZ34501.1

NCBI Reference Sequences

More...RefSeqi		XP_003861203.1, XM_003861155.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CBZ34501; CBZ34501; LDBPK_241120

GeneDB pathogen genome database from Sanger Institute

More...GeneDBi		LdBPK_241120.1.1:pep

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13390888

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ldo:LDBPK_241120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799611 Genomic DNA Translation: CBZ34501.1
RefSeqiXP_003861203.1, XM_003861155.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblProtistsiCBZ34501; CBZ34501; LDBPK_241120
GeneDBiLdBPK_241120.1.1:pep
GeneIDi13390888
KEGGildo:LDBPK_241120

Organism-specific databases

EuPathDBiTriTrypDB:LdBPK_241120.1

Phylogenomic databases

HOGENOMiHOG000175261
OMAiDEMGCAL

Family and domain databases

InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9BGX5_LEIDB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9BGX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 31, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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