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UniProtKB - E9BA99 (E9BA99_LEIDB)
Protein
Mitogen-activated protein kinase
Gene
LDBPK_100540
Organism
Leishmania donovani (strain BPK282A1)
Status
Functioni
Catalytic activityi
- EC:2.7.11.24UniRule annotation
Cofactori
Mg2+UniRule annotation
Activity regulationi
Activated by threonine and tyrosine phosphorylation.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 63 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- MAP kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, MagnesiumUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinaseUniRule annotationARBA annotation (EC:2.7.11.24UniRule annotationARBA annotation) |
Gene namesi | ORF Names:LDBPK_100540Imported |
Organismi | Leishmania donovani (strain BPK282A1)Imported |
Taxonomic identifieri | 981087 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | TriTrypDB:LdBPK_100540.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 320 | Protein kinaseInterPro annotationAdd BLAST | 288 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 365 – 388 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 366 – 382 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Phylogenomic databases
OMAi | QGHAFES |
PhylomeDBi | E9BA99 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
E9BA99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHKSNQELSV PKIVGDFKVY NVSGSPFEVP SKYTLLKILG MGAYGIACSC
60 70 80 90 100
LDGDTGEKVS IKKCRDVFRD VEDGKRVLRE IDMMRFFHHE NLLNVVNILP
110 120 130 140 150
PLKREYHSFE DVYVVTPLMD VDMNVVLRSR QVLEESHMQY FVYQILRGLK
160 170 180 190 200
YLHSANVAHR DLKPANLVTN ISCELKIIDF GLSRSVDVPY SELTDYVITR
210 220 230 240 250
WYRPPELLLE NTNYSTAVDI WSVGCIFAEM YNRKPVFPGR NTMDQLRMIA
260 270 280 290 300
QHIGKPPASI VEHREALEKL NELPDGSLNI PKLVPGLAGN TEGIDFLSKM
310 320 330 340 350
WTLDPSKRPT AADMLAHPYL AHLHDEEDEP TCPCPFLWAH ESTPMGVSEL
360 370 380
RRAFWADIVD YNPSLEQATP PVTTAGGSSS KNGSGHHH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR799597 Genomic DNA Translation: CBZ32172.1 |
RefSeqi | XP_003858890.1, XM_003858842.1 |
Genome annotation databases
EnsemblProtistsi | CBZ32172; CBZ32172; LDBPK_100540 |
GeneIDi | 13389285 |
KEGGi | ldo:LDBPK_100540 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR799597 Genomic DNA Translation: CBZ32172.1 |
RefSeqi | XP_003858890.1, XM_003858842.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4O2Z | X-ray | 2.71 | A | 5-363 | [»] | |
SMRi | E9BA99 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
EnsemblProtistsi | CBZ32172; CBZ32172; LDBPK_100540 |
GeneIDi | 13389285 |
KEGGi | ldo:LDBPK_100540 |
Organism-specific databases
VEuPathDBi | TriTrypDB:LdBPK_100540.1 |
Phylogenomic databases
OMAi | QGHAFES |
PhylomeDBi | E9BA99 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9BA99_LEIDB | |
Accessioni | E9BA99Primary (citable) accession number: E9BA99 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |