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UniProtKB - E9AW04 (E9AW04_LEIMU)
Protein
Submitted name:
Peroxidoxin (Tryparedoxin peroxidase)
Gene
LMXM_23_0040
Organism
Leishmania mexicana (strain MHOM/GT/2001/U1103)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
UniRule annotationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 81 | Cysteine sulfenic acid (-SOH) intermediateUniRule annotation | 1 |
GO - Molecular functioni
- peroxidase activity Source: UniProtKB-UniRule
- peroxiredoxin activity Source: InterPro
Keywordsi
Molecular function | AntioxidantUniRule annotation, Oxidoreductase, PeroxidaseUniRule annotationImported |
Protein family/group databases
PeroxiBasei | 11261, Lmex2CysPrx |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:LMXM_23_0040Imported |
Organismi | Leishmania mexicana (strain MHOM/GT/2001/U1103)Imported |
Taxonomic identifieri | 929439 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | TriTrypDB:LmxM.23.0040 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 194 | ThioredoxinInterPro annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the peroxiredoxin family.UniRule annotation
Keywords - Domaini
Redox-active centerUniRule annotationPhylogenomic databases
OMAi | MDYQMYR |
PhylomeDBi | E9AW04 |
Family and domain databases
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
E9AW04-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRRLSTSCF LKRAQFRGFA ATSPLLNMDY QMYRTATVRE AAPQFSGQAV
60 70 80 90 100
VNGAIKEINS NDYKGKYIVL FFYPMDFTFV CPTEIIAFSD RHAEFEKRNT
110 120 130 140 150
QVIAVSCDSV YSHLAWVNTP RKKGGLGEMH IPVLADKSME IARDYGVLIE
160 170 180 190 200
ESGIALRGLF IIDKKGVLRH ATINDLPVGR NVDEALRVLE AFQYADENGD
210 220
AIPCGWKPGQ PTLDTTKAGE FFEKNM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR799576 Genomic DNA Translation: CBZ27138.1 |
RefSeqi | XP_003875626.1, XM_003875577.1 |
Genome annotation databases
GeneIDi | 13454439 |
KEGGi | lmi:LMXM_23_0040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR799576 Genomic DNA Translation: CBZ27138.1 |
RefSeqi | XP_003875626.1, XM_003875577.1 |
3D structure databases
SMRi | E9AW04 |
ModBasei | Search... |
Protein family/group databases
PeroxiBasei | 11261, Lmex2CysPrx |
Genome annotation databases
GeneIDi | 13454439 |
KEGGi | lmi:LMXM_23_0040 |
Organism-specific databases
VEuPathDBi | TriTrypDB:LmxM.23.0040 |
Phylogenomic databases
OMAi | MDYQMYR |
PhylomeDBi | E9AW04 |
Family and domain databases
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9AW04_LEIMU | |
Accessioni | E9AW04Primary (citable) accession number: E9AW04 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |