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Protein

Thiamine kinase

Gene

thiK

Organism
Salmonella typhimurium (strain 4/74)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of thiamine to thiamine phosphate.UniRule annotation

Catalytic activityi

ATP + thiamine = ADP + thiamine phosphate.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamine kinase (thiK)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00060;UER00596

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine kinaseUniRule annotation (EC:2.7.1.89UniRule annotation)
Gene namesi
Name:thiKUniRule annotationImported
Ordered Locus Names:STM474_1205Imported
OrganismiSalmonella typhimurium (strain 4/74)Imported
Taxonomic identifieri909946 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008978 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE8XEX6
SMRiE8XEX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 230APHInterPro annotationAdd BLAST198

Sequence similaritiesi

Belongs to the thiamine kinase family.UniRule annotation

Phylogenomic databases

KOiK07251
OMAiDVHAGNI
OrthoDBiPOG091H05FN

Family and domain databases

HAMAPiMF_01604 Thiamine_kinase, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR011009 Kinase-like_dom_sf
IPR014093 Thiamine_kinase
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR02721 ycfN_thiK, 1 hit

Sequencei

Sequence statusi: Complete.

E8XEX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSNNNNPLT RDEILSRYFP QYRPAVATSQ GLSGGSCIIA HDTHRVVLRR
60 70 80 90 100
HHDPDAPPAH FLRHYRALSQ LPASLAPRAL FYTPGWMAVE YLHGVVNSAL
110 120 130 140 150
PDADELAALL YHLHQQPRFG WRIALSPLLA QYWSCCDPAR RTPFWLRRLK
160 170 180 190 200
QLQKNGEPRP LRLAPLHMDV HGDNIVLTSA GLRLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVEDERQH RQLADAYAAR ARIDARQLWR QIRLWHPWVI MLKAGWFEYR
260 270
WRQTGEQQFI RLADETWRQL RMKG
Length:274
Mass (Da):31,941
Last modified:April 5, 2011 - v1
Checksum:iAE29F8621639A575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002487 Genomic DNA Translation: ADX16907.1
RefSeqiWP_001257342.1, NC_016857.1

Genome annotation databases

EnsemblBacteriaiADX16907; ADX16907; STM474_1205
KEGGiseb:STM474_1205
PATRICifig|909946.3.peg.1234

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002487 Genomic DNA Translation: ADX16907.1
RefSeqiWP_001257342.1, NC_016857.1

3D structure databases

ProteinModelPortaliE8XEX6
SMRiE8XEX6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX16907; ADX16907; STM474_1205
KEGGiseb:STM474_1205
PATRICifig|909946.3.peg.1234

Phylogenomic databases

KOiK07251
OMAiDVHAGNI
OrthoDBiPOG091H05FN

Enzyme and pathway databases

UniPathwayi
UPA00060;UER00596

Family and domain databases

HAMAPiMF_01604 Thiamine_kinase, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR011009 Kinase-like_dom_sf
IPR014093 Thiamine_kinase
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR02721 ycfN_thiK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE8XEX6_SALT4
AccessioniPrimary (citable) accession number: E8XEX6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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