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Protein

Alanine racemase

Gene

Astex_1273

Organism
Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Astex_1273)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Active sitei267Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei315Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAEXC573065:G1GPE-1269-MONOMER
UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Astex_1273Imported
OrganismiAsticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)Imported
Taxonomic identifieri573065 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeAsticcacaulis
Proteomesi
  • UP000001492 Componenti: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi573065.Astex_1273

Structurei

3D structure databases

ProteinModelPortaliE8RNQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 372Ala_racemase_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

E8RNQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQALANEAL TNGAGGILRV DLGALKANYL KLCQLAAPTP VSAVVKADAY
60 70 80 90 100
GLGVKAVSAT LHAVGCRHFF VALTREAFEL RSHLPTDAAL YVLNGLTPGS
110 120 130 140 150
EARAAEARLI PVLDCPEQLD AWAAVARQRG QTLPALLQVD TGMSRLGFMP
160 170 180 190 200
EDLKALATAQ ERLQGLRIDY LMSHLACADE PANPANGQQL EAFEMASRLF
210 220 230 240 250
PDTPLCFANS GGLFLGAEYH ADLCRPGIAL YGAAPHLDRP NPMQPVIALD
260 270 280 290 300
LAVLQTRTVP AGTRIGYGGT VVTDAPKRLA TLSAGYADGL PRRLGDQGAV
310 320 330 340 350
YFKGTRLPFI GRVSMDSIII DIDALPEGTL KTGDFVELIG PHQSLDAVAE
360 370
AAGTIAYEIL TQLGPRYHRH LIVAEG
Length:376
Mass (Da):39,879
Last modified:April 5, 2011 - v1
Checksum:iD120730F2FB54D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002395 Genomic DNA Translation: ADU12948.1
RefSeqiWP_013478780.1, NC_014816.1

Genome annotation databases

EnsemblBacteriaiADU12948; ADU12948; Astex_1273
KEGGiaex:Astex_1273

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002395 Genomic DNA Translation: ADU12948.1
RefSeqiWP_013478780.1, NC_014816.1

3D structure databases

ProteinModelPortaliE8RNQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573065.Astex_1273

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU12948; ADU12948; Astex_1273
KEGGiaex:Astex_1273

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

BioCyciAEXC573065:G1GPE-1269-MONOMER

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE8RNQ2_ASTEC
AccessioniPrimary (citable) accession number: E8RNQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 10, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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