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Entry version 48 (26 Feb 2020)
Sequence version 1 (05 Apr 2011)
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Protein

Beta-L-arabinobiosidase

Gene

hypBA2

Organism
Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta-L-arabinobiosidase that removes L-arabinofuranose-beta-1,2-L-arabinofuranose disaccharide from various substrates such as carrot extensin and potato lectin. Also acts on L-arabinofuranose (Ara)-beta-1,2-Ara-beta-1,2-Ara-beta-Hyp (Ara3-Hyp) but not on Ara-beta-1,3-Ara-beta-1,2-Ara-beta-1,2-Ara-beta--Hyp (Ara4-Hyp) or Ara-beta-1,2-Ara-beta-Hyp (Ara2-Hyp), suggesting a specificity for unmodified Ara3-Hyp substrate. In the presence of 1-alkanols, shows transglycosylation activity, retaining the anomeric configuration of the arabinofuranose residue.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 5.5-6.0.1 Publication

Temperature dependencei

Optimum temperature is 30 degrees Celsius.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BLON565042:G1GTK-234-MONOMER
MetaCyc:MONOMER-18165

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH121 Glycoside Hydrolase Family 121

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-L-arabinobiosidase (EC:3.2.1.187)
Alternative name(s):
Arabinofuranosyl(3)-Hyp beta-L-arabinobiosidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hypBA2
Ordered Locus Names:BLLJ_0212
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri565042 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1908 – 1928HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Tat-type signalPROSITE-ProRule annotationAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042355633 – 1943Beta-L-arabinobiosidaseAdd BLAST1911

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E8MGH9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E8MGH9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini892 – 1049F5/8 type C 1Add BLAST158
Domaini1061 – 1157PKDAdd BLAST97
Domaini1142 – 1302F5/8 type C 2Add BLAST161
Domaini1678 – 1716FIVAR 1Add BLAST39
Domaini1746 – 1790FIVAR 2Add BLAST45
Domaini1823 – 1864FIVAR 3Add BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 121 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002496_0_0_11

KEGG Orthology (KO)

More...
KOi
K18206

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWIHHTQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.10, 1 hit
2.60.120.260, 3 hits
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR011081 Big_4
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR006311 TAT_signal

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07532 Big_4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF49785 SSF49785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51318 TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

E8MGH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHHSTRKRWL ASIGAVAAVA TLATGGAVTA QAADAPVIKN ADVAYPSFKG
60 70 80 90 100
SDDPMKTAAN NTTYNPAVSY LQETFDNDVK NLAGIDTDHD FWIDKILTRT
110 120 130 140 150
GAQPTGKGTN DKGAYSYEGS DGNNYLFTRG RAAYMYTHTP NQLGFVGDTA
160 170 180 190 200
YWDQTSRSGF TVTVNADGSN QTLNEDASQR KQTPSYFTSL FQTGGKSLKI
210 220 230 240 250
KEVKYITYNN VMVANLTVES TQDRDVTLTT ASPFAAEGAD GATELTGRVN
260 270 280 290 300
VKNNLTTIYP RFSANNQDGS NWIVSGGKLT STLSLKANEP QTVKIQLGLI
310 320 330 340 350
ANELPDSTKE YEARYTGDLK DAAASYKDSV TTYNKWWVDN APYVDTPEDN
360 370 380 390 400
IDKTVVYRWW LSRFNMLDAN MPGNTFQYPT SIEGVLGYNN QIVLTSGMFM
410 420 430 440 450
MDTKWFRNPE YSYGTWLSAG DTAKKSKAGY YYYHDNPGDP ANWNHSYTQY
460 470 480 490 500
ITRAGWDSYK VHGGPSTVAE ELADQGAEDV QGLLASKSEP DNNDNQNNND
510 520 530 540 550
NSLIDWSWWS MTGNDADAVS FSEPGRSGQR MDRADGSANM WANANAAAQA
560 570 580 590 600
YKAAGDTANA EKMQAIADKI QKEVTTELWD KSDNLLKHKW LNDGAFAKYK
610 620 630 640 650
EINNYYPYSE GLMPTGNEDY NKALRLFEDS NEFPIFPFFT ANQADKAALN
660 670 680 690 700
FPGSNNFSII NAQPLLQVYS AGIRNYDAAK NGYITNEQFK KLLYWVAFAH
710 720 730 740 750
YQGGDNNYPD QNEFWNEDNN NVGDVNGDGV INNLDKNLDA AQNGGKITYR
760 770 780 790 800
SWIHHTQLGT TNWTMVEDVA GMVPREDNKI ELNPIEIPGW NYFTVNNLRY
810 820 830 840 850
HDQDVSIVWD KDGSHYGGPA GYSLYVGGKL AFTSDKLAHL IYDPAAGTVE
860 870 880 890 900
VKDDSSAQVT VGAEAVKNVK AANQVTFNAD QRVTDLFAKS GTNVDSASKS
910 920 930 940 950
TTNVAKDADV TGTTYAEKDT NYPAKNAVDG KTVMESFWGT KGSENKTDTL
960 970 980 990 1000
NIKFKDGKQK IDDIRLYFYQ SSSSQTISGY AEPANYKLEY QKDDGTWAPI
1010 1020 1030 1040 1050
ADQVRTPNYA GANYNRIQFT PVETTTIRVT FTPQAGMAVG VKEIEAYNTG
1060 1070 1080 1090 1100
IKADGTSENQ TPQVDAYVSS STSSGAKLVG TVKDDGLPAE GDVTTTWSQV
1110 1120 1130 1140 1150
SGPEGGTAKF VDASAASTTV TFNKEGDYVL KLTASDGEKE GSKEITVHGI
1160 1170 1180 1190 1200
PSDGTVNVAP QSSASASYTN GYQPKDNAKK VIDGQVVYAN TPNETWNNWG
1210 1220 1230 1240 1250
DSTGVEPWLQ LKWAGKVPLK KAKVFFWTDG GGVPMVSSWK LQYADADGNW
1260 1270 1280 1290 1300
QDVKLADGQS YTVNRNEGNE VKFADAVETD KLRVVFPKGA IVGASEFEAY
1310 1320 1330 1340 1350
AIEPVSVDEV NRLVQTGSKA DDLKLPSTVS AVYTDGSRRD LAVTWGKVTD
1360 1370 1380 1390 1400
AQLAADAVFD VKGTVAGALN GTVAHIAARS DTASQTVGNA QPVEQTVYQN
1410 1420 1430 1440 1450
AKSIDLPATV PVKFPNGYND DRKVTWKDAD IKAIDLTKVG DYEVAGTVDD
1460 1470 1480 1490 1500
GSSSAAAKLT VHVVADPNGS STPEPEPEPL VGWIEGKATR TTISPDSEAT
1510 1520 1530 1540 1550
WSPAEGKLND GVVVDDTWPT TDDQNVNDKV WGSWGKAKDG MYAQYDFGQS
1560 1570 1580 1590 1600
VTIDQSRAQF WANFAETDDS KGGLEVPDAW KIQYLAEDGS WKDVEPTEDY
1610 1620 1630 1640 1650
TVVRNSPASR ADTDAKGWSA VTFKPVTTKS LRLVLTPYTG SSTFGAAVAE
1660 1670 1680 1690 1700
WGVHGIDGTE PEPTPVDKTA LESALDTANG LDASRYTAAS WAEFQQIIDA
1710 1720 1730 1740 1750
AQAVYDDANA TAEQVAEQVT KLEDGQKALV ALATDVEKST LQAAIDAAKA
1760 1770 1780 1790 1800
EAASGKYTDK SVEALNKAIE AAEGVLKVGE VGEVTQAAVQ EASASLNKAV
1810 1820 1830 1840 1850
KALEEKPAAE TVKKESLEAS IEQAKKADKS KYTEEAWQAL QSQIAAAQKV
1860 1870 1880 1890 1900
YDDKDAKQAD VDAAQDALDK AFWATKVEQK PGSQQPGVTD TDKDDKDNKG
1910 1920 1930 1940
DRVPPTGAAV SVVAAAAVLL TAAGVTILKR RQSGDHGSAR HSA
Length:1,943
Mass (Da):210,438
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5193BD671F72CAB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB562506 Genomic DNA Translation: BAJ34647.1
AP010888 Genomic DNA Translation: BAJ65882.1

NCBI Reference Sequences

More...
RefSeqi
WP_013582352.1, NC_015067.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAJ65882; BAJ65882; BLLJ_0212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
blm:BLLJ_0212

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB562506 Genomic DNA Translation: BAJ34647.1
AP010888 Genomic DNA Translation: BAJ65882.1
RefSeqiWP_013582352.1, NC_015067.1

3D structure databases

SMRiE8MGH9
ModBaseiSearch...

Protein family/group databases

CAZyiGH121 Glycoside Hydrolase Family 121

Proteomic databases

PRIDEiE8MGH9

Genome annotation databases

EnsemblBacteriaiBAJ65882; BAJ65882; BLLJ_0212
KEGGiblm:BLLJ_0212

Phylogenomic databases

HOGENOMiCLU_002496_0_0_11
KOiK18206
OMAiSWIHHTQ

Enzyme and pathway databases

BioCyciBLON565042:G1GTK-234-MONOMER
MetaCyc:MONOMER-18165

Family and domain databases

Gene3Di1.50.10.10, 1 hit
2.60.120.260, 3 hits
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR011081 Big_4
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR006311 TAT_signal
PfamiView protein in Pfam
PF07532 Big_4, 2 hits
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49785 SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS51318 TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYBA2_BIFL2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E8MGH9
Secondary accession number(s): E7FK76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: April 5, 2011
Last modified: February 26, 2020
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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