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Entry version 40 (11 Dec 2019)
Sequence version 1 (05 Apr 2011)
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Protein

1,3-beta-galactosyl-N-acetylhexosamine phosphorylase

Gene

lnpA

Organism
Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversibly phosphorolyzes lacto-N-biose to Gal1-P and N-acetylglucosamine (GlcNAc) and galacto-N-biose to Gal1-P and N-acetylgalactosamine (GalNAc). Involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei313Proton donor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BLON565042:G1GTK-1738-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.211 851

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH112 Glycoside Hydrolase Family 112

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC:2.4.1.211)
Alternative name(s):
Galacto-N-biose/lacto-N-biose I phosphorylase
Short name:
GLNBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lnpA
Synonyms:lnbp
Ordered Locus Names:BLLJ_1623
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri565042 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32R → E: Lack of activity. 1 Publication1
Mutagenesisi166N → A: Strong decrease in activity. 1 Publication1
Mutagenesisi210R → E: Lack of activity. 1 Publication1
Mutagenesisi358R → E: Lack of activity. 1 Publication1
Mutagenesisi362Y → F: Strong decrease in activity. 1 Publication1
Mutagenesisi362Y → N: Lack of activity. 1 Publication1
Mutagenesisi364F → N: Decrease in activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004240701 – 7511,3-beta-galactosyl-N-acetylhexosamine phosphorylaseAdd BLAST751

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E8MF13

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1751
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
E8MF13

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycoside hydrolase 112 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015674

KEGG Orthology (KO)

More...
KOi
K15533

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMHEYTV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.1180, 1 hit
3.40.50.880, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029062 Class_I_gatase-like
IPR013780 Glyco_hydro_b
IPR013783 Ig-like_fold
IPR035080 Lact_bio_phlase-like_N
IPR012711 Lacto-N-biose_phosphorylase
IPR035356 LBP_C
IPR035363 LBP_M

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09508 Lact_bio_phlase, 1 hit
PF17386 LBP_C, 1 hit
PF17385 LBP_M, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52317 SSF52317, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02336 TIGR02336, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E8MF13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSTGRFTLP SEENFAEKTK ELAELWGADA IRNSDGTHLD EAVLALGKKI
60 70 80 90 100
YNAYFPTRAH NEWITLHMDE TPQVYLLTDR ILAESDTVDI PLMESFFAEQ
110 120 130 140 150
LKPNRDADPH KYWEVVDRTT GEVVDSANWT LDADEDTVHV SGVAAWHEYT
160 170 180 190 200
VSFLAYIIWD PVEMYNHLTN DWGDKEHEIP FDIYHPATRK FVFDTFEQWL
210 220 230 240 250
KDSPQTDVVR FTTFFYQFTL LFDEKRREKV VDWFGCACTV SPRALDDFEA
260 270 280 290 300
KYGYRLRPED FVDGGAYNSA WRVPRKAQRD WIDFLSGFVR ENVKQLADMS
310 320 330 340 350
HAAGKEAMMF LGDQWIGTEP YKDGFDELGL DAVVGSIGDG TTTRMIADIP
360 370 380 390 400
GVKYTEGRFL PYFFPDTFYE GNDPSIEGLD NWRKARRAIL RSPISRMGYG
410 420 430 440 450
GYLSLAAKFP KFVDTVTHIA NEFRDIHDRT GGVAAEGELN VAILNSWGKM
460 470 480 490 500
RSWMAFTVAH ALPNKQTYSY YGILESLSGM RVNVRFISFD DVLAHGIDSD
510 520 530 540 550
IDVIINGGPV DTAFTGGDVW TNPKLVETVR AWVRGGGAFV GVGEPSSAPR
560 570 580 590 600
FQTGRFFQLA DVIGVDEERY QTLSVDKYFP PVVPDHFITA DVPVDPAARE
610 620 630 640 650
AWEQAGYRIP LSGCGGGQSI KPLGGIDFGE PVLNTYPVNE NVTLLRADGG
660 670 680 690 700
QVQLATNDYG KGRGVYISGL PYSAANARLL ERVLFYASHN EDKYAAWSSS
710 720 730 740 750
NPECEVAHFP EQGLYCVINN TDQPQKTTVT LADGTTEDFD LPDSGIAWRE

A
Length:751
Mass (Da):84,327
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2C4E2471C6761EB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB181926 Genomic DNA Translation: BAD80751.1
AB303839 Genomic DNA Translation: BAF73924.1
AP010888 Genomic DNA Translation: BAJ67290.1

NCBI Reference Sequences

More...
RefSeqi
WP_007056738.1, NC_015067.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAJ67290; BAJ67290; BLLJ_1623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
blm:BLLJ_1623

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB181926 Genomic DNA Translation: BAD80751.1
AB303839 Genomic DNA Translation: BAF73924.1
AP010888 Genomic DNA Translation: BAJ67290.1
RefSeqiWP_007056738.1, NC_015067.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZUSX-ray2.11A/B/C/D1-751[»]
2ZUTX-ray1.90A/B/C/D1-751[»]
2ZUUX-ray2.30A/B/C/D1-751[»]
2ZUVX-ray1.85A/B1-751[»]
2ZUWX-ray2.11A/B/C/D1-751[»]
3WFZX-ray2.60A/B/C/D1-751[»]
SMRiE8MF13
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

CAZyiGH112 Glycoside Hydrolase Family 112

Proteomic databases

PRIDEiE8MF13

Genome annotation databases

EnsemblBacteriaiBAJ67290; BAJ67290; BLLJ_1623
KEGGiblm:BLLJ_1623

Phylogenomic databases

HOGENOMiHOG000015674
KOiK15533
OMAiPMHEYTV

Enzyme and pathway databases

BioCyciBLON565042:G1GTK-1738-MONOMER
BRENDAi2.4.1.211 851

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.1180, 1 hit
3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR013780 Glyco_hydro_b
IPR013783 Ig-like_fold
IPR035080 Lact_bio_phlase-like_N
IPR012711 Lacto-N-biose_phosphorylase
IPR035356 LBP_C
IPR035363 LBP_M
PfamiView protein in Pfam
PF09508 Lact_bio_phlase, 1 hit
PF17386 LBP_C, 1 hit
PF17385 LBP_M, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR02336 TIGR02336, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLNPA_BIFL2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E8MF13
Secondary accession number(s): Q5NU17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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