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Entry version 36 (07 Oct 2020)
Sequence version 2 (19 Feb 2014)
Previous versions | rss
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Protein

Polycystic kidney disease 1 like 1

Gene

pkd1l1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a ciliary calcium channel that controls calcium concentration within cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with pkd2l1 in cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and gli2 transcription. Does not constitute the pore-forming subunit (By similarity). Also involved in left/right axis specification downstream of nodal flow: forms a complex with pkd2 in cilia to facilitate flow detection in left/right patterning.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease 1 like 1
Alternative name(s):
Protein abecobe
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pkd1l1
Synonyms:abc
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001038 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000265180 Componenti: Chromosome 9
  • UP000265200 Componenti: Chromosome 9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1602ExtracellularSequence analysisAdd BLAST1602
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1603 – 1623HelicalSequence analysisAdd BLAST21
Topological domaini1624 – 1812CytoplasmicSequence analysisAdd BLAST189
Transmembranei1813 – 1833HelicalSequence analysisAdd BLAST21
Topological domaini1834 – 1851ExtracellularSequence analysisAdd BLAST18
Transmembranei1852 – 1872HelicalSequence analysisAdd BLAST21
Topological domaini1873 – 2005CytoplasmicSequence analysisAdd BLAST133
Transmembranei2006 – 2026HelicalSequence analysisAdd BLAST21
Topological domaini2027 – 2040ExtracellularSequence analysisAdd BLAST14
Transmembranei2041 – 2061HelicalSequence analysisAdd BLAST21
Topological domaini2062 – 2151CytoplasmicSequence analysisAdd BLAST90
Transmembranei2152 – 2172HelicalSequence analysisAdd BLAST21
Topological domaini2173 – 2344ExtracellularSequence analysisAdd BLAST172
Transmembranei2345 – 2365HelicalSequence analysisAdd BLAST21
Topological domaini2366 – 2378CytoplasmicSequence analysisAdd BLAST13
Transmembranei2379 – 2401HelicalSequence analysisAdd BLAST23
Topological domaini2402 – 2442ExtracellularSequence analysisAdd BLAST41
Transmembranei2443 – 2463HelicalSequence analysisAdd BLAST21
Topological domaini2464 – 2467CytoplasmicSequence analysis4
Transmembranei2468 – 2488HelicalSequence analysisAdd BLAST21
Topological domaini2489 – 2528ExtracellularSequence analysisAdd BLAST40
Transmembranei2529 – 2549HelicalSequence analysisAdd BLAST21
Topological domaini2550 – 2742CytoplasmicSequence analysisAdd BLAST193

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects in left-right axis patterning, while nodal flow is normal.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004255501 – 2742Polycystic kidney disease 1 like 1Add BLAST2742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi693N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi735N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1080N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1490N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E7FKV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in Kupffer's vesicle, an organ equivalent to the node.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with PKD2 proteins to form a calcium channel.

Interacts with pkd2l1; to form ciliary calcium channel (By similarity).

Interacts with pkd2.

By similarity1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini286 – 372PKD 1PROSITE-ProRule annotationAdd BLAST87
Domaini370 – 454PKD 2PROSITE-ProRule annotationAdd BLAST85
Domaini452 – 1338REJPROSITE-ProRule annotationAdd BLAST887
Domaini1538 – 1586GPSPROSITE-ProRule annotationAdd BLAST49
Domaini1648 – 1769PLATPROSITE-ProRule annotationAdd BLAST122

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000203, GPS
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR014010, REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825, GPS, 1 hit
PF00801, PKD, 2 hits
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00308, LH2, 1 hit
SM00089, PKD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 2 hits
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50221, GPS, 1 hit
PS50093, PKD, 2 hits
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7FKV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFCLWIFSLA FLHLHLCSVS SSSLEGSGFF VGWINASSLQ LFASIGGCDL
60 70 80 90 100
SPCMDEGQEG MEALYRSEEP FQCSIRASAS PGRRQAGRTC VRKVPGNLAV
110 120 130 140 150
HCHLLSENEG LEEEDLLRIT VMTPRGQSSL QVNVSHGGLL TACSDWIWNT
160 170 180 190 200
SEKHKNNVPA SGLHLGISLE VPCCTSCTRF GSDSELVEEQ CSALHVSVSD
210 220 230 240 250
VLVKDYICCL TPRDKDKTLN RTETPCLYSS NSLKDSLVRG RVYQMSFEEC
260 270 280 290 300
FRWHLLVVLL MLEAQYNHSQ EVHEDPSSTV KLCDYAVRIH AEKQAYSTNT
310 320 330 340 350
DIPLLAVVDI LDPVEFLWDF GDFTSARANS RTITKRYTNP GIYKLVVVAS
360 370 380 390 400
WGQMSVRSHV LSLVVQRAVK LNRLVHEPSV LQNHTVTVSC RVNVGTNLTF
410 420 430 440 450
LWNFGDGTVR TGLSTEQHVF TRTGEFRVMV IASNLVSSAS LSSYLFVVDR
460 470 480 490 500
PCQPPPVKNL GPPNIQVRRN EVVFLGVTFE SELNCNVSRE LHYSWTVYDS
510 520 530 540 550
AGLTFPLPLT NTHRQSLVLQ SYTLPYGIYK AIARVQIVGS VVYSNYSVRL
560 570 580 590 600
QVVPNSVVVV IQGGTNIYVN TKSSNEVTLD GQASYDPDFP LNPLRYSWTC
610 620 630 640 650
QPVSTISSSC FSQSIPTSYP VLKFPTSLLK SNFDQFKFTL TVHSGERSAS
660 670 680 690 700
SEIFLTLTSH LAGKLFVHCP ECQGDQVSWD QSFSVRAECE DCNVSAEFIQ
710 720 730 740 750
YSWSLFRVNA SSKPVAEIPF CYTVDLNAPS AVLENASTPT PAPEMSPSHH
760 770 780 790 800
FNADWTRFTE DSLASSSPSR IYKSKNRNSE LTDSPVSSVT VGFSGSESFN
810 820 830 840 850
GPPGVDRGSS QFSNFPGQRD MFSEFQSDPE SSAEWEFTFP YLESEDLRGQ
860 870 880 890 900
RGDSRVPFPR PEEGDPGISA GRPKETDMES FPSDSDSFSH SSSNKGEGSN
910 920 930 940 950
LVDPRPSVRL QKPGLLDLHR DSVDKSLFES YTYTGISSCF LSFRSFSLKP
960 970 980 990 1000
SSTYMLELTA KSQRRFYGQT QLFLKVKPVP KGVACQVQPV RGIELYTHFS
1010 1020 1030 1040 1050
IFCTSGREDL IYTYSFSVGG RMPRILYQGR DFLYYFSLPS GDPTDDYKVI
1060 1070 1080 1090 1100
IYTEIRSSMY GSAKKLCPVT VRVEPSFVRN ASSSYSHHEP DLMISDSGLR
1110 1120 1130 1140 1150
NVSVLVQLGN IAEIYNYISL LSTILNRLSL DSQANTHALK HLRNVLICIV
1160 1170 1180 1190 1200
CKLEYSAQAS PADGIFILNE LLRVTSQVTV QSARWVTAHV GALSVQFSES
1210 1220 1230 1240 1250
NRSILSALVS LLSSSLQVVT SSPETSDSAD SPQPLESHLV TGKSRNAFVD
1260 1270 1280 1290 1300
DADHCITDLS ETTYNKQSEP VPKRLMMRLV NDLLQTTSDL MLRNFDLQKT
1310 1320 1330 1340 1350
KELQVQSDLI TLCAGFLNKT STAINCGLIT FFLPASLIKM LLLHDGISAK
1360 1370 1380 1390 1400
RGFSQREQPS CVQRIGMELL HNPYEWGRYP IQLKGPVADL SLYSCKTRRK
1410 1420 1430 1440 1450
IPVHSFLQPI TVELRHPQKT SSMSEYTLLR SQINYHNFSI TQEHLQQAVQ
1460 1470 1480 1490 1500
VTVVFTAPPH MAFPVKILFR MFERPTPSMH HLHRLLNWRN NTILLTLPPS
1510 1520 1530 1540 1550
YLSAAGVGHL ALLDANFGKT PTRRHLAEQI SYSLTVESSL CLSWEDQQGS
1560 1570 1580 1590 1600
WTQNGCRAQT NDKTSAVNCS CHHLKPLKVL QQQIQSSHFR ADLDQFLSVS
1610 1620 1630 1640 1650
RDLTVVFVLL LCVSLNIPVL VWCKKTDATS EENNRAHFLP DNSATDQHFY
1660 1670 1680 1690 1700
AVTVHTGLCS AARMSARVYV VLHGEDGCSQ TKELHVPGCT LFRRNSQNTF
1710 1720 1730 1740 1750
ILSVADSLGS VQGVHIWHNN SGPSPEWYLK QVQVSELMPG HMEGRSWQFI
1760 1770 1780 1790 1800
SQCWLAVNKG DGQVERMLRV STHGLTFSKM LFLKLFEYMP DYHIWMSVYT
1810 1820 1830 1840 1850
CPSPHLFTRA QRLCVCLLLF LGYACVNIII THQRDDQLPF DLGVIDVTSV
1860 1870 1880 1890 1900
SIATGLVSVV AVLPVAMVIS FLFRVKSGRM TLENYDNVFS KRPSGKTKYQ
1910 1920 1930 1940 1950
DTDFLSVSTT NLENKDADDK EAVTPQRNKR RKDSVSFESI HELLFQEVLQ
1960 1970 1980 1990 2000
VSRRRSLFLK KSKGNDSELS PQSSEFCGAL KATKNEAQSV RVKRRYRLAS
2010 2020 2030 2040 2050
LLYHCVAWTL CLLFCLSCLI LSAVLGTRLN SGKILHWIHS LFVSLTFCFF
2060 2070 2080 2090 2100
VIHPATILVL AAVVSWRFKR SQDFHCFFNK MNSHLEDLKH QDPDQLRPSA
2110 2120 2130 2140 2150
FTRTRAPNAE KILEARQRAR YLRRVHPPTR AELRKTRTKR KKQAVIHKML
2160 2170 2180 2190 2200
RDLCLCGSMF FLMVCITYGS PVDEHYPLNA AFRRHFIRAH GDDFMSIKKY
2210 2220 2230 2240 2250
EDWWKWAQTS LLSSLYYNES ENPQMSFISI GAPLVQKTEV CGTFHSQVSM
2260 2270 2280 2290 2300
VTPPRPRYHT GSSSKQEVTV GLGYTRSEGA SKLRLLHLSG WLSEQTVALK
2310 2320 2330 2340 2350
VQFSLYSPAP NLFSSVTLLS EQSSTGLLQS SATVQSVRLY HSPSMLDYTV
2360 2370 2380 2390 2400
MVWQLLFLLL SLVNLYHQTS TAAQHGLMGY WKTTSISVEV SLVIVSLVYY
2410 2420 2430 2440 2450
VHYVYHPTMV MEVAEQLRRN HREHVDVSTL ANSEQFSRTL RGIILFLLAV
2460 2470 2480 2490 2500
KCVTVVRLNR ILAPSMPLLS LSSLLWPAIS GLLLLSIFSC MGRLLYIERT
2510 2520 2530 2540 2550
FHSIQTVLWH FWSLRKSRDL ISLWRDFYYF GLLYASSAML TTMVFAVMIR
2560 2570 2580 2590 2600
KAKRSPSTKN DPTIREVLGC ISQKFTGMKT QIPDCHTQKT YFLEECESLV
2610 2620 2630 2640 2650
DELLFKLNAL SNSLHHTLPP KLHTYTDKDS PDASSTTELC KERLQDLVRS
2660 2670 2680 2690 2700
LSVGQGEAAL TFPHDRSLLE LQEEEEVKHQ EGRCSVGCKE SRLPETLWTA
2710 2720 2730 2740
DYRESMDEHW TEKKSSNGLG GATYSHVVVV EALVHHEQGT KN
Length:2,742
Mass (Da):308,537
Last modified:February 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD9D7BD479F71201
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti847L → R in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti974L → F in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1064K → T in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1245R → G in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1263T → K in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1328L → S in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1360S → P in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1467I → L in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1513L → F in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1616N → Y in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1814C → Y in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1833Q → K in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti1924T → Q in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2014F → L in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2036H → L in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2182F → I in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2189A → G in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2192D → E in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2195M → T in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2257R → C in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2348Y → C in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2425V → I in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2567V → I in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2647L → S in BAJ65629 (PubMed:21307098).Curated1
Sequence conflicti2665D → V in BAJ65629 (PubMed:21307098).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB573426 mRNA Translation: BAJ65629.1
BAAF04039115 Genomic DNA No translation available.
BAAF04039116 Genomic DNA No translation available.
BAAF04039117 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB573426 mRNA Translation: BAJ65629.1
BAAF04039115 Genomic DNA No translation available.
BAAF04039116 Genomic DNA No translation available.
BAAF04039117 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiE7FKV8

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR000203, GPS
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR014010, REJ_dom
PfamiView protein in Pfam
PF01825, GPS, 1 hit
PF00801, PKD, 2 hits
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
SMARTiView protein in SMART
SM00308, LH2, 1 hit
SM00089, PKD, 2 hits
SUPFAMiSSF49299, SSF49299, 2 hits
SSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50221, GPS, 1 hit
PS50093, PKD, 2 hits
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK1L1_ORYLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FKV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: February 19, 2014
Last modified: October 7, 2020
This is version 36 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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