UniProtKB - E7FKV8 (PK1L1_ORYLA)
Protein
Polycystic kidney disease 1 like 1
Gene
pkd1l1
Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Functioni
Component of a ciliary calcium channel that controls calcium concentration within cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with pkd2l1 in cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and gli2 transcription. Does not constitute the pore-forming subunit (By similarity). Also involved in left/right axis specification downstream of nodal flow: forms a complex with pkd2 in cilia to facilitate flow detection in left/right patterning.By similarity1 Publication
GO - Molecular functioni
- calcium channel activity Source: UniProtKB
GO - Biological processi
- detection of mechanical stimulus Source: UniProtKB
- detection of nodal flow Source: UniProtKB
- left/right axis specification Source: UniProtKB
Keywordsi
Molecular function | Calcium channel, Ion channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Polycystic kidney disease 1 like 1Alternative name(s): Protein abecobe |
Gene namesi | Name:pkd1l1 Synonyms:abc |
Organismi | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Taxonomic identifieri | 8090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Ovalentaria › Atherinomorphae › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- cilium membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- ciliary membrane Source: UniProtKB-SubCell
Other locations
- calcium channel complex Source: UniProtKB
- cilium Source: UniProtKB
- non-motile cilium Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 1602 | ExtracellularSequence analysisAdd BLAST | 1602 | |
Transmembranei | 1603 – 1623 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1624 – 1812 | CytoplasmicSequence analysisAdd BLAST | 189 | |
Transmembranei | 1813 – 1833 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1834 – 1851 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 1852 – 1872 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1873 – 2005 | CytoplasmicSequence analysisAdd BLAST | 133 | |
Transmembranei | 2006 – 2026 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2027 – 2040 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 2041 – 2061 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2062 – 2151 | CytoplasmicSequence analysisAdd BLAST | 90 | |
Transmembranei | 2152 – 2172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2173 – 2344 | ExtracellularSequence analysisAdd BLAST | 172 | |
Transmembranei | 2345 – 2365 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2366 – 2378 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 2379 – 2401 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 2402 – 2442 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 2443 – 2463 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2464 – 2467 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 2468 – 2488 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2489 – 2528 | ExtracellularSequence analysisAdd BLAST | 40 | |
Transmembranei | 2529 – 2549 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2550 – 2742 | CytoplasmicSequence analysisAdd BLAST | 193 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cilium, MembranePathology & Biotechi
Disruption phenotypei
Defects in left-right axis patterning, while nodal flow is normal.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000425550 | 1 – 2742 | Polycystic kidney disease 1 like 1Add BLAST | 2742 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 35 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 149 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 267 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 397 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 486 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 545 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 693 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 709 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 735 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1080 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1318 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1437 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1490 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1568 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | E7FKV8 |
Expressioni
Tissue specificityi
Expressed in Kupffer's vesicle, an organ equivalent to the node.1 Publication
Interactioni
Subunit structurei
Heterodimer; heterodimerizes with PKD2 proteins to form a calcium channel.
Interacts with pkd2l1; to form ciliary calcium channel (By similarity).
Interacts with pkd2.
By similarity1 PublicationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 286 – 372 | PKD 1PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 370 – 454 | PKD 2PROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 452 – 1338 | REJPROSITE-ProRule annotationAdd BLAST | 887 | |
Domaini | 1538 – 1586 | GPSPROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 1648 – 1769 | PLATPROSITE-ProRule annotationAdd BLAST | 122 |
Sequence similaritiesi
Belongs to the polycystin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR000203, GPS IPR013783, Ig-like_fold IPR022409, PKD/Chitinase_dom IPR002859, PKD/REJ-like IPR013122, PKD1_2_channel IPR000601, PKD_dom IPR035986, PKD_dom_sf IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR014010, REJ_dom |
Pfami | View protein in Pfam PF01825, GPS, 1 hit PF00801, PKD, 2 hits PF08016, PKD_channel, 1 hit PF01477, PLAT, 1 hit PF02010, REJ, 1 hit |
SMARTi | View protein in SMART SM00308, LH2, 1 hit SM00089, PKD, 2 hits |
SUPFAMi | SSF49299, SSF49299, 2 hits SSF49723, SSF49723, 1 hit |
PROSITEi | View protein in PROSITE PS50221, GPS, 1 hit PS50093, PKD, 2 hits PS50095, PLAT, 1 hit PS51111, REJ, 1 hit |
i Sequence
Sequence statusi: Complete.
E7FKV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFCLWIFSLA FLHLHLCSVS SSSLEGSGFF VGWINASSLQ LFASIGGCDL
60 70 80 90 100
SPCMDEGQEG MEALYRSEEP FQCSIRASAS PGRRQAGRTC VRKVPGNLAV
110 120 130 140 150
HCHLLSENEG LEEEDLLRIT VMTPRGQSSL QVNVSHGGLL TACSDWIWNT
160 170 180 190 200
SEKHKNNVPA SGLHLGISLE VPCCTSCTRF GSDSELVEEQ CSALHVSVSD
210 220 230 240 250
VLVKDYICCL TPRDKDKTLN RTETPCLYSS NSLKDSLVRG RVYQMSFEEC
260 270 280 290 300
FRWHLLVVLL MLEAQYNHSQ EVHEDPSSTV KLCDYAVRIH AEKQAYSTNT
310 320 330 340 350
DIPLLAVVDI LDPVEFLWDF GDFTSARANS RTITKRYTNP GIYKLVVVAS
360 370 380 390 400
WGQMSVRSHV LSLVVQRAVK LNRLVHEPSV LQNHTVTVSC RVNVGTNLTF
410 420 430 440 450
LWNFGDGTVR TGLSTEQHVF TRTGEFRVMV IASNLVSSAS LSSYLFVVDR
460 470 480 490 500
PCQPPPVKNL GPPNIQVRRN EVVFLGVTFE SELNCNVSRE LHYSWTVYDS
510 520 530 540 550
AGLTFPLPLT NTHRQSLVLQ SYTLPYGIYK AIARVQIVGS VVYSNYSVRL
560 570 580 590 600
QVVPNSVVVV IQGGTNIYVN TKSSNEVTLD GQASYDPDFP LNPLRYSWTC
610 620 630 640 650
QPVSTISSSC FSQSIPTSYP VLKFPTSLLK SNFDQFKFTL TVHSGERSAS
660 670 680 690 700
SEIFLTLTSH LAGKLFVHCP ECQGDQVSWD QSFSVRAECE DCNVSAEFIQ
710 720 730 740 750
YSWSLFRVNA SSKPVAEIPF CYTVDLNAPS AVLENASTPT PAPEMSPSHH
760 770 780 790 800
FNADWTRFTE DSLASSSPSR IYKSKNRNSE LTDSPVSSVT VGFSGSESFN
810 820 830 840 850
GPPGVDRGSS QFSNFPGQRD MFSEFQSDPE SSAEWEFTFP YLESEDLRGQ
860 870 880 890 900
RGDSRVPFPR PEEGDPGISA GRPKETDMES FPSDSDSFSH SSSNKGEGSN
910 920 930 940 950
LVDPRPSVRL QKPGLLDLHR DSVDKSLFES YTYTGISSCF LSFRSFSLKP
960 970 980 990 1000
SSTYMLELTA KSQRRFYGQT QLFLKVKPVP KGVACQVQPV RGIELYTHFS
1010 1020 1030 1040 1050
IFCTSGREDL IYTYSFSVGG RMPRILYQGR DFLYYFSLPS GDPTDDYKVI
1060 1070 1080 1090 1100
IYTEIRSSMY GSAKKLCPVT VRVEPSFVRN ASSSYSHHEP DLMISDSGLR
1110 1120 1130 1140 1150
NVSVLVQLGN IAEIYNYISL LSTILNRLSL DSQANTHALK HLRNVLICIV
1160 1170 1180 1190 1200
CKLEYSAQAS PADGIFILNE LLRVTSQVTV QSARWVTAHV GALSVQFSES
1210 1220 1230 1240 1250
NRSILSALVS LLSSSLQVVT SSPETSDSAD SPQPLESHLV TGKSRNAFVD
1260 1270 1280 1290 1300
DADHCITDLS ETTYNKQSEP VPKRLMMRLV NDLLQTTSDL MLRNFDLQKT
1310 1320 1330 1340 1350
KELQVQSDLI TLCAGFLNKT STAINCGLIT FFLPASLIKM LLLHDGISAK
1360 1370 1380 1390 1400
RGFSQREQPS CVQRIGMELL HNPYEWGRYP IQLKGPVADL SLYSCKTRRK
1410 1420 1430 1440 1450
IPVHSFLQPI TVELRHPQKT SSMSEYTLLR SQINYHNFSI TQEHLQQAVQ
1460 1470 1480 1490 1500
VTVVFTAPPH MAFPVKILFR MFERPTPSMH HLHRLLNWRN NTILLTLPPS
1510 1520 1530 1540 1550
YLSAAGVGHL ALLDANFGKT PTRRHLAEQI SYSLTVESSL CLSWEDQQGS
1560 1570 1580 1590 1600
WTQNGCRAQT NDKTSAVNCS CHHLKPLKVL QQQIQSSHFR ADLDQFLSVS
1610 1620 1630 1640 1650
RDLTVVFVLL LCVSLNIPVL VWCKKTDATS EENNRAHFLP DNSATDQHFY
1660 1670 1680 1690 1700
AVTVHTGLCS AARMSARVYV VLHGEDGCSQ TKELHVPGCT LFRRNSQNTF
1710 1720 1730 1740 1750
ILSVADSLGS VQGVHIWHNN SGPSPEWYLK QVQVSELMPG HMEGRSWQFI
1760 1770 1780 1790 1800
SQCWLAVNKG DGQVERMLRV STHGLTFSKM LFLKLFEYMP DYHIWMSVYT
1810 1820 1830 1840 1850
CPSPHLFTRA QRLCVCLLLF LGYACVNIII THQRDDQLPF DLGVIDVTSV
1860 1870 1880 1890 1900
SIATGLVSVV AVLPVAMVIS FLFRVKSGRM TLENYDNVFS KRPSGKTKYQ
1910 1920 1930 1940 1950
DTDFLSVSTT NLENKDADDK EAVTPQRNKR RKDSVSFESI HELLFQEVLQ
1960 1970 1980 1990 2000
VSRRRSLFLK KSKGNDSELS PQSSEFCGAL KATKNEAQSV RVKRRYRLAS
2010 2020 2030 2040 2050
LLYHCVAWTL CLLFCLSCLI LSAVLGTRLN SGKILHWIHS LFVSLTFCFF
2060 2070 2080 2090 2100
VIHPATILVL AAVVSWRFKR SQDFHCFFNK MNSHLEDLKH QDPDQLRPSA
2110 2120 2130 2140 2150
FTRTRAPNAE KILEARQRAR YLRRVHPPTR AELRKTRTKR KKQAVIHKML
2160 2170 2180 2190 2200
RDLCLCGSMF FLMVCITYGS PVDEHYPLNA AFRRHFIRAH GDDFMSIKKY
2210 2220 2230 2240 2250
EDWWKWAQTS LLSSLYYNES ENPQMSFISI GAPLVQKTEV CGTFHSQVSM
2260 2270 2280 2290 2300
VTPPRPRYHT GSSSKQEVTV GLGYTRSEGA SKLRLLHLSG WLSEQTVALK
2310 2320 2330 2340 2350
VQFSLYSPAP NLFSSVTLLS EQSSTGLLQS SATVQSVRLY HSPSMLDYTV
2360 2370 2380 2390 2400
MVWQLLFLLL SLVNLYHQTS TAAQHGLMGY WKTTSISVEV SLVIVSLVYY
2410 2420 2430 2440 2450
VHYVYHPTMV MEVAEQLRRN HREHVDVSTL ANSEQFSRTL RGIILFLLAV
2460 2470 2480 2490 2500
KCVTVVRLNR ILAPSMPLLS LSSLLWPAIS GLLLLSIFSC MGRLLYIERT
2510 2520 2530 2540 2550
FHSIQTVLWH FWSLRKSRDL ISLWRDFYYF GLLYASSAML TTMVFAVMIR
2560 2570 2580 2590 2600
KAKRSPSTKN DPTIREVLGC ISQKFTGMKT QIPDCHTQKT YFLEECESLV
2610 2620 2630 2640 2650
DELLFKLNAL SNSLHHTLPP KLHTYTDKDS PDASSTTELC KERLQDLVRS
2660 2670 2680 2690 2700
LSVGQGEAAL TFPHDRSLLE LQEEEEVKHQ EGRCSVGCKE SRLPETLWTA
2710 2720 2730 2740
DYRESMDEHW TEKKSSNGLG GATYSHVVVV EALVHHEQGT KN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 847 | L → R in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 974 | L → F in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1064 | K → T in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1245 | R → G in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1263 | T → K in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1328 | L → S in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1360 | S → P in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1467 | I → L in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1513 | L → F in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1616 | N → Y in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1814 | C → Y in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1833 | Q → K in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 1924 | T → Q in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2014 | F → L in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2036 | H → L in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2182 | F → I in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2189 | A → G in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2192 | D → E in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2195 | M → T in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2257 | R → C in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2348 | Y → C in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2425 | V → I in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2567 | V → I in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2647 | L → S in BAJ65629 (PubMed:21307098).Curated | 1 | |
Sequence conflicti | 2665 | D → V in BAJ65629 (PubMed:21307098).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB573426 mRNA Translation: BAJ65629.1 BAAF04039115 Genomic DNA No translation available. BAAF04039116 Genomic DNA No translation available. BAAF04039117 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB573426 mRNA Translation: BAJ65629.1 BAAF04039115 Genomic DNA No translation available. BAAF04039116 Genomic DNA No translation available. BAAF04039117 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | E7FKV8 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR000203, GPS IPR013783, Ig-like_fold IPR022409, PKD/Chitinase_dom IPR002859, PKD/REJ-like IPR013122, PKD1_2_channel IPR000601, PKD_dom IPR035986, PKD_dom_sf IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR014010, REJ_dom |
Pfami | View protein in Pfam PF01825, GPS, 1 hit PF00801, PKD, 2 hits PF08016, PKD_channel, 1 hit PF01477, PLAT, 1 hit PF02010, REJ, 1 hit |
SMARTi | View protein in SMART SM00308, LH2, 1 hit SM00089, PKD, 2 hits |
SUPFAMi | SSF49299, SSF49299, 2 hits SSF49723, SSF49723, 1 hit |
PROSITEi | View protein in PROSITE PS50221, GPS, 1 hit PS50093, PKD, 2 hits PS50095, PLAT, 1 hit PS51111, REJ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PK1L1_ORYLA | |
Accessioni | E7FKV8Primary (citable) accession number: E7FKV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 19, 2014 |
Last sequence update: | February 19, 2014 | |
Last modified: | October 7, 2020 | |
This is version 36 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families