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Entry version 66 (07 Apr 2021)
Sequence version 1 (08 Mar 2011)
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Protein

Vitamin B12-dependent ribonucleoside-diphosphate reductase

Gene

rnr

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

adenosylcob(III)alamin1 PublicationNote: 5'-deoxyadenosylcobalamine (coenzyme B12).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=70 µM for CDP (at 80 degrees Celsius)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: DNA replication

    This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
    View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei257SubstrateBy similarity1
    Binding sitei301Substrate; via amide nitrogenBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei913Proton acceptorBy similarity1
    Active sitei1297Cysteine radical intermediateBy similarity1
    Active sitei1299Proton acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionEndonuclease, Hydrolase, Nuclease, Oxidoreductase
    Biological processDNA replication
    LigandATP-binding, Cobalamin, Cobalt, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-15780
    PFUR186497:G1FZR-462-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.17.4.1, 5243

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00326

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Vitamin B12-dependent ribonucleoside-diphosphate reductase (EC:1.17.4.1)
    Short name:
    B12-dependent RNR
    Alternative name(s):
    Ribonucleotide reductase
    Cleaved into the following 2 chains:
    Endonuclease PI-PfuI (EC:3.1.-.-)
    Alternative name(s):
    Pfu rnr-1 intein
    Pfu rnr-2 intein (EC:3.1.-.-)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:rnr
    Ordered Locus Names:PF0440
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004287821 – 301Vitamin B12-dependent ribonucleoside-diphosphate reductase, 1st partSequence analysisAdd BLAST301
    ChainiPRO_0000428783302 – 755Endonuclease PI-PfuISequence analysisAdd BLAST454
    ChainiPRO_0000428784756 – 914Vitamin B12-dependent ribonucleoside-diphosphate reductase, 2nd partSequence analysisAdd BLAST159
    ChainiPRO_0000428785915 – 1296Pfu rnr-2 inteinSequence analysisAdd BLAST382
    ChainiPRO_00004287861297 – 1740Vitamin B12-dependent ribonucleoside-diphosphate reductase, 3rd partSequence analysisAdd BLAST444

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi273 ↔ 1308Redox-activeBy similarity

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Protein splicing

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    E7FHX6, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    186497.PF0440

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    11740
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    E7FHX6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    E7FHX6

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 96ATP-conePROSITE-ProRule annotationAdd BLAST93
    Domaini443 – 582DOD-type homing endonuclease 1PROSITE-ProRule annotationAdd BLAST140
    Domaini1063 – 1194DOD-type homing endonuclease 2PROSITE-ProRule annotationAdd BLAST132

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni272 – 273Substrate bindingBy similarity2
    Regioni913 – 914Substrate bindingBy similarity2
    Regioni1297 – 1299Substrate bindingBy similarity3
    Regioni1471 – 1475Substrate bindingBy similarity5

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    arCOG03151, Archaea
    arCOG03154, Archaea
    arCOG04276, Archaea

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000404_2_3_2

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ISNGFMS

    Database of Orthologous Groups

    More...
    OrthoDBi
    4783at2157

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd02888, RNR_II_dimer, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.10.28.10, 3 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005144, ATP-cone_dom
    IPR003586, Hint_dom_C
    IPR003587, Hint_dom_N
    IPR036844, Hint_dom_sf
    IPR027434, Homing_endonucl
    IPR006142, INTEIN
    IPR030934, Intein_C
    IPR004042, Intein_endonuc
    IPR006141, Intein_N
    IPR004860, LAGLIDADG_2
    IPR015147, PI-PfuI_intein_endonucl_subdom
    IPR000788, RNR_lg_C
    IPR013509, RNR_lsu_N
    IPR013344, RNR_NrdJ/NrdZ
    IPR008926, RNR_R1-su_N
    IPR015146, RNR_stirrup

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03477, ATP-cone, 1 hit
    PF09062, Endonuc_subdom, 1 hit
    PF14528, LAGLIDADG_3, 2 hits
    PF02867, Ribonuc_red_lgC, 1 hit
    PF00317, Ribonuc_red_lgN, 1 hit
    PF09061, Stirrup, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00379, INTEIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00305, HintC, 2 hits
    SM00306, HintN, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48168, SSF48168, 1 hit
    SSF51294, SSF51294, 2 hits
    SSF55608, SSF55608, 4 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01443, intein_Cterm, 2 hits
    TIGR01445, intein_Nterm, 2 hits
    TIGR02504, NrdJ_Z, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51161, ATP_CONE, 1 hit
    PS50818, INTEIN_C_TER, 2 hits
    PS50819, INTEIN_ENDONUCLEASE, 2 hits
    PS50817, INTEIN_N_TER, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    E7FHX6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAVEKVMKRD GRIVPFDESR IRWAVQRAMW EVGIRDEKKL DEVVKSIVQR
    60 70 80 90 100
    INELYDGKIP HIENIQDIVE LELMRAGLFE VAKAYILYRK KKAEIREEKK
    110 120 130 140 150
    RILNKKELDE IDKRFSINAL RVLASRYLKK DENGNIVESP RELFERVAIL
    160 170 180 190 200
    AVIPDLLYDE RVFDKNGNYS QDLKRVEYYL EHFEEFDRKY SIGKYKLNKY
    210 220 230 240 250
    HFERMVNLYK ELAEQGKMKV SIDEFLAMLE KGEFNEYEKE INEYFRLMTN
    260 270 280 290 300
    QIFMPNTPAL INSGRPLGML SACFVVPIED DMESIMKAAH DVAMIQKMGG
    310 320 330 340 350
    GCIDGKAKII FENEGEEHLT TMEEMYERYK HLGEFYDEEY NRWGIDVSNV
    360 370 380 390 400
    PIYVKSFDPE SKRVVKGKVN VIWKYELGKD VTKYEIITNK GTKILTSPWH
    410 420 430 440 450
    PFFVLTPDFK IVEKRADELK EGDILIGGMP DGEDYKFIFD YWLAGFIAGD
    460 470 480 490 500
    GCFDKYHSHV KGHEYIYDRL RIYDYRIETF EIINDYLEKT FGRKYSIQKD
    510 520 530 540 550
    RNIYYIDIKA RNITSHYLKL LEGIDNGIPP QILKEGKNAV LSFIAGLFDA
    560 570 580 590 600
    EGHVSNKPGI ELGMVNKRLI EDVTHYLNAL GIKARIREKL RKDGIDYVLH
    610 620 630 640 650
    VEEYSSLLRF YELIGKNLQN EEKREKLEKV LSNHKGGNFG LPLNFNAFKE
    660 670 680 690 700
    WASEYGVEFK TNGSQTIAII NDERISLGQW HTRNRVSKAV LVKMLRKLYE
    710 720 730 740 750
    ATKDEEVKRM LHLIEGLEVV RHITTTNEPR TFYDLTVENY QNYLAGENGM
    760 770 780 790 800
    IFVHNTGLNF SKLRPEGDIV GTTTGAASGP VSFMHLIDAV SDVIKQGGVR
    810 820 830 840 850
    RGANMGILEI WHPDIEKFIH AKEKNIGTNV LSNFNISVGI WEDFWEALKE
    860 870 880 890 900
    GKKYPLINPR TGEVVKEVDP KTLFEELAYM AWAKADPGVI FFDVINRRNV
    910 920 930 940 950
    LKKAKGGPIR ATNPCVVGDT RILTPEGYLK AEEIFSLAKE RGKKEAVAVE
    960 970 980 990 1000
    GIAEEGEPYA YSVEILLPGE EKVEYETVHG KVLAVADPVA VPAYVWKVGR
    1010 1020 1030 1040 1050
    KKVARVKTKE GYEITATLDH KLMTPEGWKE VGKLKEGDKI LLPRFEVEEE
    1060 1070 1080 1090 1100
    FGSESIGEDL AFVLGWFIGD GYLNVNDKRA WFYFNAEKEE EIAVRIRDIL
    1110 1120 1130 1140 1150
    VKHFGIKAEL HRYGNQIKLG VRGEAYRWLE NIVKNNEKRI PEIVYRLKPR
    1160 1170 1180 1190 1200
    EIAAFLRGLF SADGYVDKDM AIRLTSKSRE LLREVQDLLL LFGILSKIYE
    1210 1220 1230 1240 1250
    KPYESEFHYT TKNGEERIYR SKGYYELVIT NYSRKLFAEK IGLEGYKMEK
    1260 1270 1280 1290 1300
    LSLKKTKVDQ PIVTVESVEV LGEEIVYDFT VPNYHMYISN GFMSHNCGEE
    1310 1320 1330 1340 1350
    PLYEYESCNL ASINLAKFVK YDENGKPYFD WDEYAYVIQK VAKYLDNSID
    1360 1370 1380 1390 1400
    VNKFPLPEID YNTKLTRRIG VGMMGLADAL FKLGIPYNSE EGFKFMRKVT
    1410 1420 1430 1440 1450
    EYLTFYAYKY SVEAAKKRGT FPLYDKTEYP EGKLPVEGFY HPEIWNLPWD
    1460 1470 1480 1490 1500
    KLVEEIKKYG LRNAMVTTCP PTGSVSMIAD TSSGIEPVYA LVYKKSVTVG
    1510 1520 1530 1540 1550
    EFYYVDPVFE EELKKRGLYS EELLKKISDN YGSVQGLEEI PEDMQRVFVT
    1560 1570 1580 1590 1600
    ALDIHWLDHI IAQASIQMWL TDSASKTINM INEATVEDVK AAYLIARFLG
    1610 1620 1630 1640 1650
    CKGVTVYRDG SLSVQVYSVE GEKKKRRFKP KPSEYAKKIL LEIVEKEPWI
    1660 1670 1680 1690 1700
    KNFINVDEIL NGKKEQLLFS LRPANESKLK VPGREEEVRP GNIPEEKIRE
    1710 1720 1730 1740
    LLGVVYCPVC YEKEGKLVEL KMESGCATCP VCGWSKCVIS
    Length:1,740
    Mass (Da):200,932
    Last modified:March 8, 2011 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49B27D2C17C3913B
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U78098 Genomic DNA Translation: AAB36947.1
    AE009950 Genomic DNA Translation: AAL80564.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T43215

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_011011558.1, NC_018092.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAL80564; AAL80564; PF0440

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    41712240

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    pfu:PF0440

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|186497.12.peg.464

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U78098 Genomic DNA Translation: AAB36947.1
    AE009950 Genomic DNA Translation: AAL80564.1
    PIRiT43215
    RefSeqiWP_011011558.1, NC_018092.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DQ3X-ray2.10A302-755[»]
    SMRiE7FHX6
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    IntActiE7FHX6, 1 interactor
    STRINGi186497.PF0440

    Genome annotation databases

    EnsemblBacteriaiAAL80564; AAL80564; PF0440
    GeneIDi41712240
    KEGGipfu:PF0440
    PATRICifig|186497.12.peg.464

    Phylogenomic databases

    eggNOGiarCOG03151, Archaea
    arCOG03154, Archaea
    arCOG04276, Archaea
    HOGENOMiCLU_000404_2_3_2
    OMAiISNGFMS
    OrthoDBi4783at2157

    Enzyme and pathway databases

    UniPathwayiUPA00326
    BioCyciMetaCyc:MONOMER-15780
    PFUR186497:G1FZR-462-MONOMER
    BRENDAi1.17.4.1, 5243

    Miscellaneous databases

    EvolutionaryTraceiE7FHX6

    Family and domain databases

    CDDicd02888, RNR_II_dimer, 1 hit
    Gene3Di3.10.28.10, 3 hits
    InterProiView protein in InterPro
    IPR005144, ATP-cone_dom
    IPR003586, Hint_dom_C
    IPR003587, Hint_dom_N
    IPR036844, Hint_dom_sf
    IPR027434, Homing_endonucl
    IPR006142, INTEIN
    IPR030934, Intein_C
    IPR004042, Intein_endonuc
    IPR006141, Intein_N
    IPR004860, LAGLIDADG_2
    IPR015147, PI-PfuI_intein_endonucl_subdom
    IPR000788, RNR_lg_C
    IPR013509, RNR_lsu_N
    IPR013344, RNR_NrdJ/NrdZ
    IPR008926, RNR_R1-su_N
    IPR015146, RNR_stirrup
    PfamiView protein in Pfam
    PF03477, ATP-cone, 1 hit
    PF09062, Endonuc_subdom, 1 hit
    PF14528, LAGLIDADG_3, 2 hits
    PF02867, Ribonuc_red_lgC, 1 hit
    PF00317, Ribonuc_red_lgN, 1 hit
    PF09061, Stirrup, 1 hit
    PRINTSiPR00379, INTEIN
    SMARTiView protein in SMART
    SM00305, HintC, 2 hits
    SM00306, HintN, 2 hits
    SUPFAMiSSF48168, SSF48168, 1 hit
    SSF51294, SSF51294, 2 hits
    SSF55608, SSF55608, 4 hits
    TIGRFAMsiTIGR01443, intein_Cterm, 2 hits
    TIGR01445, intein_Nterm, 2 hits
    TIGR02504, NrdJ_Z, 1 hit
    PROSITEiView protein in PROSITE
    PS51161, ATP_CONE, 1 hit
    PS50818, INTEIN_C_TER, 2 hits
    PS50819, INTEIN_ENDONUCLEASE, 2 hits
    PS50817, INTEIN_N_TER, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDRZ_PYRFU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FHX6
    Secondary accession number(s): P95484, Q7LX09
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: March 8, 2011
    Last modified: April 7, 2021
    This is version 66 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
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