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Entry version 75 (07 Oct 2020)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

WD repeat domain 19

Gene

wdr19

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
WD repeat domain 19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wdr19Imported
Synonyms:si:dkey-251e24.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-090313-277, wdr19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7FGG5

PeptideAtlas

More...
PeptideAtlasi
E7FGG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000037406, Expressed in testis and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7FGG5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000114539

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 175WD_REPEATS_REGIONInterPro annotationAdd BLAST126

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2247, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00590000083165

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003002_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTLVRIH

Database of Orthologous Groups

More...
OrthoDBi
215211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7FGG5

TreeFam database of animal gene trees

More...
TreeFami
TF314758

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977, Apc4_WD40_dom
IPR011990, TPR-like_helical_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR040379, WDR19/dyf-2
IPR039468, WDR19_WD40_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR14920, PTHR14920, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF15911, WD40_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E7FGG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRVFTLSEK SWSGSCLQYK WQKTVGNYLA VAGPDNLVKI FDRHGQKVNE
60 70 80 90 100
LNLPGNCVSL DWDKDGDILA VIAEKSSSVY LWDANVNKTS QLDSGMRDQM
110 120 130 140 150
SFLLWSKTGP LLAVGTSKGN LLIYNQQTSR KIPVLGKHTK KITCGCWSSQ
160 170 180 190 200
NLLALGSEDR SITISNHEGD TIRQTSVRAD PADVQFSVMK TDERSSPGQS
210 220 230 240 250
TVSVALGKKT LFLFNLNDPD NPIELAFQQR YGNIISYRWY GDGYIMIGFS
260 270 280 290 300
HGYFVVISTH IREIGQELFQ AHNHKDSLTS IAISQSLNKA ASCGDNCIKI
310 320 330 340 350
HDLTDLKEMY AIVTLDEETK GLDQMCWTDD GQLLAVSSQQ GTLHVFLTKL
360 370 380 390 400
PILGDSSGTR IAYLTSLLEV TVANPVEGES PVPVAVEVEP SFIAVGPYHV
410 420 430 440 450
AVGMNNRAWF YALGDSGVER VKDTEYLGTV ASMCLNCDYA AALFEGKLQL
460 470 480 490 500
HVIDGDEQVV QEDRQTKLFP EPDQKYRILS HALTSDFLYY GTDTGLIQCF
510 520 530 540 550
YFEDWQSVTE YRHTVGVRKV FPDPNGTRLV FIDEKSDGFL YCPVNDSVFE
560 570 580 590 600
IPDFSPAIKG VLWENWISSK GVFVAYEEDK VYTYAFHKDT IQGSKVILVG
610 620 630 640 650
GTKLPFSHKP LLLHNGELTC QTQSGKINSV VLNTHAFLNN QHSESSKDKL
660 670 680 690 700
QSFLQQAVML KRFSDAWSIC KALNSSEAWG ELGRACLHHM EVELAIRVYR
710 720 730 740 750
MMGNVGMVMS LEDIKGIEDQ NLLAGHLAMF CNDYNRAQDL YLTSSYPMAA
760 770 780 790 800
LEMRRDLQHW DSALQLAKRL DPDEIPFISK EYAIQLEFVG DYVNALAHYE
810 820 830 840 850
KGTTGNNKFQ DHDESCLAGV ARMSIRMGDI RRGANQAIKH PSKALKKDCG
860 870 880 890 900
AILESMKQYS EAAQLYEKGQ YYDKAASVYI RCKNWAKVGE LLPHVTSPKI
910 920 930 940 950
HLQYAKAKEA DGKYKEAAMA YESARDWDNV IRILLEHLNN PEEAVRIVRE
960 970 980 990 1000
THSIEGAKMV ARFFLRLSDY GSAIQFLVLS RCSDEAFQLA QQHGQMEVYA
1010 1020 1030 1040 1050
DIIGSEATIE DYQSIALYFE GEKNHLQAGK FFQKCGQYSR ALKHFLKCPS
1060 1070 1080 1090 1100
SDDSVAIEMA IEAVGEAKDE SLTNQLIDHL MGESDGMPKD AKYLFRLYMA
1110 1120 1130 1140 1150
LKQYREAART AIIIAREEQS AGNYRNAHDV LFSMYAELQT QHIKIPAEMA
1160 1170 1180 1190 1200
TNLMILHSYI LVKIHVKRGD HLKGARMLIR VSNNISKFPS HIVPILTSAV
1210 1220 1230 1240 1250
IECHRAGLRN SAFSFASMLM RPEYRNKIDL KYKKKIEAMV RRPDTSEVEE
1260 1270 1280 1290 1300
ESSPCPYCGF SLPDCELLCP GCKNNLPYCI ATGRHMVKED WCVCPHCDFP
1310 1320 1330 1340
ALHSQFTQLL ETESVCPMCS EALNVSEVKK VLECSKYLQQ DQLEH
Length:1,345
Mass (Da):151,337
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i744963AB2297C47F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8RPA6A0A2R8RPA6_DANRE
WD repeat domain 19
wdr19
1,372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RMT9A0A2R8RMT9_DANRE
WD repeat domain 19
wdr19
857Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PY59A0A2R8PY59_DANRE
WD repeat domain 19
wdr19
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RWR7A0A2R8RWR7_DANRE
WD repeat domain 19
wdr19
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QRZ1F1QRZ1_DANRE
WD repeat domain 19
wdr19 si:dkey-251e24.6
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284619 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005170991.1, XM_005170934.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000131257; ENSDARP00000114539; ENSDARG00000037406

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284619 Genomic DNA No translation available.
RefSeqiXP_005170991.1, XM_005170934.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000114539

Proteomic databases

PaxDbiE7FGG5
PeptideAtlasiE7FGG5

Genome annotation databases

EnsembliENSDART00000131257; ENSDARP00000114539; ENSDARG00000037406

Organism-specific databases

ZFINiZDB-GENE-090313-277, wdr19

Phylogenomic databases

eggNOGiKOG2247, Eukaryota
GeneTreeiENSGT00590000083165
HOGENOMiCLU_003002_2_0_1
OMAiYTLVRIH
OrthoDBi215211at2759
PhylomeDBiE7FGG5
TreeFamiTF314758

Gene expression databases

BgeeiENSDARG00000037406, Expressed in testis and 24 other tissues
ExpressionAtlasiE7FGG5, baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977, Apc4_WD40_dom
IPR011990, TPR-like_helical_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR040379, WDR19/dyf-2
IPR039468, WDR19_WD40_rpt
PANTHERiPTHR14920, PTHR14920, 1 hit
PfamiView protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF15911, WD40_3, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 6 hits
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7FGG5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FGG5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 7, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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