UniProtKB - E7FGA4 (E7FGA4_DANRE)
Protein
Submitted name:
Neuregulin 2
Gene
nrg2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
GO - Biological processi
- animal organ development Source: GO_Central
- intracellular signal transduction Source: GO_Central
- nervous system development Source: InterPro
Keywordsi
Molecular function | Growth factorARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-1227986, Signaling by ERBB2 R-DRE-1236394, Signaling by ERBB4 R-DRE-1250196, SHC1 events in ERBB2 signaling R-DRE-1250342, PI3K events in ERBB4 signaling R-DRE-1250347, SHC1 events in ERBB4 signaling R-DRE-1257604, PIP3 activates AKT signaling R-DRE-1306955, GRB7 events in ERBB2 signaling R-DRE-1358803, Downregulation of ERBB2:ERBB3 signaling R-DRE-1963640, GRB2 events in ERBB2 signaling R-DRE-1963642, PI3K events in ERBB2 signaling R-DRE-5673001, RAF/MAP kinase cascade R-DRE-6785631, ERBB2 Regulates Cell Motility R-DRE-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DRE-8847993, ERBB2 Activates PTK6 Signaling R-DRE-8863795, Downregulation of ERBB2 signaling |
Names & Taxonomyi
Protein namesi | Submitted name: Neuregulin 2ImportedSubmitted name: Neuregulin 2bImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-090205-2, nrg2b |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 309 – 331 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5015090325 | 20 – 705 | Sequence analysisAdd BLAST | 686 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 254 ↔ 271 | PROSITE-ProRule annotation | ||
Disulfide bondi | 273 ↔ 282 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000086585, Expressed in brain and 17 other tissues |
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000108874 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 141 – 228 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 242 – 283 | EGF-likeInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 392 – 432 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 590 – 705 | DisorderedSequence analysisAdd BLAST | 116 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 392 – 412 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 415 – 431 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 651 – 698 | PolarSequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the neuregulin family.ARBA annotation
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QRNM, Eukaryota |
GeneTreei | ENSGT00940000158778 |
HOGENOMi | CLU_023628_0_0_1 |
InParanoidi | E7FGA4 |
OMAi | YHREDDQ |
OrthoDBi | 313400at2759 |
TreeFami | TF332469 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C |
PANTHERi | PTHR11100, PTHR11100, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E7FGA4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRLDPVHFS MLVIGVSFAC YAPSLDSLQD QAYRSAVVIE GKVSSLPENV
60 70 80 90 100
SVEPYSVNVT VLYVWPVNSG GLRREQLVTV GEFGSEAPCV AVEKHHTYIF
110 120 130 140 150
FMDPTEEPLV FKASFAPLDS TEKTLKKDVE SVLCKDCASA PKVKPMDSQW
160 170 180 190 200
LQEGKKLTLK CEAVGNPSPS FNWYKDGSQL RQKKTVKIKT NKKNSKLHIS
210 220 230 240 250
KVRLEDSGNY TCVVENSLGR ENATSFVSVQ SITTTLSPGS SHARKCNETE
260 270 280 290 300
KTYCINGGDC YFIHGINQLS CKCPNDYTGE RCQTSVMAGF YKHLGIEIME
310 320 330 340 350
AEELYQKRVL TITGICVALL VVGIVCVVAY CKTKKQRKKM HNHLHQNMCA
360 370 380 390 400
EHPNRMLANG PNHPGPGPEE IPMVDYISKN VPATERVVRH GTETSGNFSG
410 420 430 440 450
SRMSSRSHHT STASHTSSHR HEERTWSMER TDSIHSDCQS GALSSSVGTS
460 470 480 490 500
KCSSPACMEA RARRAAYCGY PDATQCSLQY GDSYDSLRDS PHSDRYVSAL
510 520 530 540 550
TTPARLSPVD FHSSLPPQVP TFQITTPNAS HALSLPPAAS AIAMAAYSPD
560 570 580 590 600
DDQPLLYRYR RSRRPYYAAE STGSLPSSPY RFVDDEDYET TQEYMSSREQ
610 620 630 640 650
PKKSSGSRRW RRRSRINGHT PGPRNYSSQS CLSDSEWEDE EVGDLGHGES
660 670 680 690 700
TPFLSMQNMN ATEPATIYRP NDTRTFSNTG RSGSRPNVQA NKLTQSRFRP
DNAPL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1QFX4 | F1QFX4_DANRE | Neuregulin 2b | nrg2b | 599 | Annotation score: | ||
A0A0R4INJ1 | A0A0R4INJ1_DANRE | Neuregulin 2b | nrg2b | 176 | Annotation score: | ||
A0A0R4IW84 | A0A0R4IW84_DANRE | Neuregulin 2b | nrg2b | 138 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005008 Genomic DNA No translation available. BX323592 Genomic DNA No translation available. CR407701 Genomic DNA No translation available. KT023305 mRNA Translation: AKS25897.1 |
RefSeqi | XP_005157176.1, XM_005157119.3 |
Genome annotation databases
Ensembli | ENSDART00000129055; ENSDARP00000108874; ENSDARG00000086585 |
GeneIDi | 100270726 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005008 Genomic DNA No translation available. BX323592 Genomic DNA No translation available. CR407701 Genomic DNA No translation available. KT023305 mRNA Translation: AKS25897.1 |
RefSeqi | XP_005157176.1, XM_005157119.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000108874 |
Genome annotation databases
Ensembli | ENSDART00000129055; ENSDARP00000108874; ENSDARG00000086585 |
GeneIDi | 100270726 |
Organism-specific databases
CTDi | 100270726 |
ZFINi | ZDB-GENE-090205-2, nrg2b |
Phylogenomic databases
eggNOGi | ENOG502QRNM, Eukaryota |
GeneTreei | ENSGT00940000158778 |
HOGENOMi | CLU_023628_0_0_1 |
InParanoidi | E7FGA4 |
OMAi | YHREDDQ |
OrthoDBi | 313400at2759 |
TreeFami | TF332469 |
Enzyme and pathway databases
Reactomei | R-DRE-1227986, Signaling by ERBB2 R-DRE-1236394, Signaling by ERBB4 R-DRE-1250196, SHC1 events in ERBB2 signaling R-DRE-1250342, PI3K events in ERBB4 signaling R-DRE-1250347, SHC1 events in ERBB4 signaling R-DRE-1257604, PIP3 activates AKT signaling R-DRE-1306955, GRB7 events in ERBB2 signaling R-DRE-1358803, Downregulation of ERBB2:ERBB3 signaling R-DRE-1963640, GRB2 events in ERBB2 signaling R-DRE-1963642, PI3K events in ERBB2 signaling R-DRE-5673001, RAF/MAP kinase cascade R-DRE-6785631, ERBB2 Regulates Cell Motility R-DRE-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DRE-8847993, ERBB2 Activates PTK6 Signaling R-DRE-8863795, Downregulation of ERBB2 signaling |
Gene expression databases
Bgeei | ENSDARG00000086585, Expressed in brain and 17 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C |
PANTHERi | PTHR11100, PTHR11100, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7FGA4_DANRE | |
Accessioni | E7FGA4Primary (citable) accession number: E7FGA4 Secondary accession number(s): A0A0K0WSF9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | January 20, 2016 | |
Last modified: | October 7, 2020 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |