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Protein
Submitted name:

Neuregulin 2

Gene

nrg2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-1227986 Signaling by ERBB2
R-DRE-1236394 Signaling by ERBB4
R-DRE-1250196 SHC1 events in ERBB2 signaling
R-DRE-1250342 PI3K events in ERBB4 signaling
R-DRE-1250347 SHC1 events in ERBB4 signaling
R-DRE-1257604 PIP3 activates AKT signaling
R-DRE-1306955 GRB7 events in ERBB2 signaling
R-DRE-1358803 Downregulation of ERBB2:ERBB3 signaling
R-DRE-1963640 GRB2 events in ERBB2 signaling
R-DRE-1963642 PI3K events in ERBB2 signaling
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-6785631 ERBB2 Regulates Cell Motility
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DRE-8847993 ERBB2 Activates PTK6 Signaling
R-DRE-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 2Imported
Submitted name:
Neuregulin 2bImported
Gene namesi
Name:nrg2bImported
Synonyms:NRG2bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-090205-2 nrg2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei309 – 331HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501528983120 – 705Sequence analysisAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi254 ↔ 271PROSITE-ProRule annotation
Disulfide bondi273 ↔ 282PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000086585 Expressed in 11 organ(s), highest expression level in brain

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108874

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 228Ig-likeInterPro annotationAdd BLAST88
Domaini242 – 283EGF-likeInterPro annotationAdd BLAST42

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IGZW Eukaryota
ENOG410Y95Z LUCA
GeneTreeiENSGT00900000140940
InParanoidiE7FGA4
OMAiDHRYIFF
OrthoDBiEOG091G032E
TreeFamiTF332469

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002154 Neuregulin_C
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF02158 Neuregulin, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

E7FGA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLDPVHFS MLVIGVSFAC YAPSLDSLQD QAYRSAVVIE GKVSSLPENV
60 70 80 90 100
SVEPYSVNVT VLYVWPVNSG GLRREQLVTV GEFGSEAPCV AVEKHHTYIF
110 120 130 140 150
FMDPTEEPLV FKASFAPLDS TEKTLKKDVE SVLCKDCASA PKVKPMDSQW
160 170 180 190 200
LQEGKKLTLK CEAVGNPSPS FNWYKDGSQL RQKKTVKIKT NKKNSKLHIS
210 220 230 240 250
KVRLEDSGNY TCVVENSLGR ENATSFVSVQ SITTTLSPGS SHARKCNETE
260 270 280 290 300
KTYCINGGDC YFIHGINQLS CKCPNDYTGE RCQTSVMAGF YKHLGIEIME
310 320 330 340 350
AEELYQKRVL TITGICVALL VVGIVCVVAY CKTKKQRKKM HNHLHQNMCA
360 370 380 390 400
EHPNRMLANG PNHPGPGPEE IPMVDYISKN VPATERVVRH GTETSGNFSG
410 420 430 440 450
SRMSSRSHHT STASHTSSHR HEERTWSMER TDSIHSDCQS GALSSSVGTS
460 470 480 490 500
KCSSPACMEA RARRAAYCGY PDATQCSLQY GDSYDSLRDS PHSDRYVSAL
510 520 530 540 550
TTPARLSPVD FHSSLPPQVP TFQITTPNAS HALSLPPAAS AIAMAAYSPD
560 570 580 590 600
DDQPLLYRYR RSRRPYYAAE STGSLPSSPY RFVDDEDYET TQEYMSSREQ
610 620 630 640 650
PKKSSGSRRW RRRSRINGHT PGPRNYSSQS CLSDSEWEDE EVGDLGHGES
660 670 680 690 700
TPFLSMQNMN ATEPATIYRP NDTRTFSNTG RSGSRPNVQA NKLTQSRFRP

DNAPL
Length:705
Mass (Da):78,341
Last modified:January 20, 2016 - v2
Checksum:iD6BEBC60DDB6C192
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QFX4F1QFX4_DANRE
Neuregulin 2b
nrg2b
599Annotation score:
A0A0R4INJ1A0A0R4INJ1_DANRE
Neuregulin 2b
nrg2b
176Annotation score:
A0A0R4IW84A0A0R4IW84_DANRE
Neuregulin 2b
nrg2b
138Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005008 Genomic DNA No translation available.
BX323592 Genomic DNA No translation available.
CR407701 Genomic DNA No translation available.
KT023305 mRNA Translation: AKS25897.1
RefSeqiXP_005157176.1, XM_005157119.3
UniGeneiDr.117716

Genome annotation databases

EnsembliENSDART00000129055; ENSDARP00000108874; ENSDARG00000086585
GeneIDi100270726

Similar proteinsi

Entry informationi

Entry nameiE7FGA4_DANRE
AccessioniPrimary (citable) accession number: E7FGA4
Secondary accession number(s): A0A0K0WSF9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: September 12, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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