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UniProtKB - E7FF76 (E7FF76_DANRE)

Entry version 80 (07 Apr 2021)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Adenylate cyclase-activating polypeptide 1a (pituitary) receptor type I

Gene

adcyap1r1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-418555, G alpha (s) signalling events
R-DRE-420092, Glucagon-type ligand receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Adenylate cyclase-activating polypeptide 1a (pituitary) receptor type IImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adcyap1r1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-050315-1, adcyap1r1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei164 – 182HelicalSequence analysisAdd BLAST19
Transmembranei218 – 237HelicalSequence analysisAdd BLAST20
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei284 – 308HelicalSequence analysisAdd BLAST25
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500995368924 – 445Sequence analysisAdd BLAST422

Keywords - PTMi

GlycoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E7FF76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000053724, Expressed in brain and 23 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000128526

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 118G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST83
Domaini130 – 381G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST252

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4564, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_4_4_1

Identification of Orthologs from Complete Genome Data

More...OMAi		CMEMMAL

Database of Orthologous Groups

More...OrthoDBi		651627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E7FF76

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR002285, GPCR_2_PACAP_1_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN
PR01156, PACAPRECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00008, HormR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418, SSF111418, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E7FF76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTVRKCQH LFLALILLPM IYCMHPDCVI QLEKEKCIER MFLDDPNSEP 
        60         70         80         90        100
ELVCRWMWDN LTCWQPARLG QVVWMPCPEL FEVMNDENNE FGKVSRNCTE 
       110        120        130        140        150
YGWSEMVPHY VDVCPFNENG TNPDMYYVSV KALYTVGYST SLVSLTTAMV 
       160        170        180        190        200
ILCKFRKLHC TRNFIHMNLF VSFILRAISV FIKDGILYAE EDSNHCFIHT 
       210        220        230        240        250
VECKAVMVFF HYCVLSNYFW LFIEGLYLFT LLVETFFPEK RYFYWYTIIG 
       260        270        280        290        300
WGTPTICVTI WAVLRAHFDN IGCWDINDNA TIWWVIKGPV LASIMINFIL 
       310        320        330        340        350
FIGIIIILVQ KLQSPDIGGN ESSIYLRLAR STLLLIPLFG IHYTVFAFTP 
       360        370        380        390        400
EDVSKRERLV FELGLGSFQG FVVAVLYCFL NGEVQSEIKR KWRSWTVNRY 
       410        420        430        440 
FAVDMKHRHP SLASSGVNGG TQLSILSKSS SQIRMSSLQA ETPAT
Length:445
Mass (Da):51,451
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6C7EBD3B9982ABF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IX63A0A0R4IX63_DANRE
Adenylate cyclase-activating polype...
adcyap1r1a
435Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IM76A0A0R4IM76_DANRE
Adenylate cyclase-activating polype...
adcyap1r1a
321Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IBR1A0A0R4IBR1_DANRE
Adenylate cyclase-activating polype...
adcyap1r1a
320Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IQT5A0A0R4IQT5_DANRE
Adenylate cyclase-activating polype...
adcyap1r1a
293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IN93A0A0R4IN93_DANRE
Adenylate cyclase-activating polype...
adcyap1r1a
202Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR628404 Genomic DNA No translation available.
CR848029 Genomic DNA No translation available.
CR853299 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_682980.3, XM_677888.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000156211; ENSDARP00000128526; ENSDARG00000053724
ENSDART00000159510; ENSDARP00000140982; ENSDARG00000053724
ENSDART00000163812; ENSDARP00000134270; ENSDARG00000113350

Database of genes from NCBI RefSeq genomes

More...GeneIDi		555473

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628404 Genomic DNA No translation available.
CR848029 Genomic DNA No translation available.
CR853299 Genomic DNA No translation available.
RefSeqiXP_682980.3, XM_677888.6

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000128526

Proteomic databases

PaxDbiE7FF76

Genome annotation databases

EnsembliENSDART00000156211; ENSDARP00000128526; ENSDARG00000053724
ENSDART00000159510; ENSDARP00000140982; ENSDARG00000053724
ENSDART00000163812; ENSDARP00000134270; ENSDARG00000113350
GeneIDi555473

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		555473
ZFINiZDB-GENE-050315-1, adcyap1r1a

Phylogenomic databases

eggNOGiKOG4564, Eukaryota
GeneTreeiENSGT00940000157362
HOGENOMiCLU_002753_4_4_1
OMAiCMEMMAL
OrthoDBi651627at2759
PhylomeDBiE7FF76

Enzyme and pathway databases

ReactomeiR-DRE-418555, G alpha (s) signalling events
R-DRE-420092, Glucagon-type ligand receptors

Gene expression databases

BgeeiENSDARG00000053724, Expressed in brain and 23 other tissues

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR002285, GPCR_2_PACAP_1_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit
PRINTSiPR00249, GPCRSECRETIN
PR01156, PACAPRECEPTR
SMARTiView protein in SMART
SM00008, HormR, 1 hit
SUPFAMiSSF111418, SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7FF76_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FF76
Secondary accession number(s): A0A0R4IJY7, A0A0R4IV15
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 7, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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